Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Chen, Chun Hsin; Pan, Chun‐Hung; Chen, Chiao Chicy; Huang, Ming

doi:10.1111/j.1530-0277.2010.01349.x

Cited by 45 publications

(37 citation statements)

References 61 publications

(67 reference statements)

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“…This finding suggests that a heightened oxidative DNA damage would not recover during early alcohol withdrawal. 46 …”

Section: Enhanced Oxidative Dna Damage Following Chronic Alcohol Consmentioning

confidence: 97%

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Alcohol Dependence in Taiwan: From Epidemiology to Biomedicine

Huang

Chen

2012

Journal of Experimental & Clinical Medicine

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“…This finding suggests that a heightened oxidative DNA damage would not recover during early alcohol withdrawal. 46 …”

Section: Enhanced Oxidative Dna Damage Following Chronic Alcohol Consmentioning

confidence: 97%

“…40 We found that AWS severity is correlated more robustly with 8-OHdG and MDA levels. 46 The phenomenon suggests that AWS, a manifestation of central glutamate overexcitation, is interwoven with oxidative damage which presumably contributes to mechanisms of addiction.…”

Section: Oxidative Stress Contributes To Alcohol Withdrawal and Addicmentioning

confidence: 99%

Alcohol Dependence in Taiwan: From Epidemiology to Biomedicine

Huang

Chen

2012

Journal of Experimental & Clinical Medicine

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“…Chronic alcohol consumption by humans and oxidative DNA damage has been correlated with withdrawal symptoms (Chen et al 2011). However, to the best of our knowledge, there is little information regarding the functional association between biochemical changes in ADE and the acquisition of alcohol dependence with respect to brain cell DNA toxicity.…”

Section: Discussionmentioning

confidence: 99%

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

et al. 2015

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“…Y. Yeh et al, 2007). Chronic alcohol exposure’s relationship to oxidative stress in the systemic circulation (Burnham et al, 2012; Yang et al, 2010), liver (C. H. Chen, Pan, Chen, & Huang, 2011; Leung & Nieto, 2013; Sid, Verrax, & Calderon, 2013), gut (Abdelmegeed et al, 2013; Keshavarzian et al, 2009; S.…”

Section: Introductionmentioning

confidence: 99%

Alcohol and lung injury and immunity

Yeligar

Chen

Kovacs

et al. 2016

Alcohol

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Annually, excessive alcohol use accounts for more than $220 billion in economic costs and 80,000 deaths, making excessive alcohol use the third leading lifestyle-related cause of death in the US. Patients with an alcohol-use disorder (AUD) also have an increased susceptibility to respiratory pathogens and lung injury, including a 2–4-fold increased risk of acute respiratory distress syndrome (ARDS). This review investigates some of the potential mechanisms by which alcohol causes lung injury and impairs lung immunity. In intoxicated individuals with burn injuries, activation of the gut-liver axis drives pulmonary inflammation, thereby negatively impacting morbidity and mortality. In the lung, the upper airway is the first checkpoint to fail in microbe clearance during alcohol-induced lung immune dysfunction. Brief and prolonged alcohol exposure drive different post-translational modifications of novel proteins that control cilia function. Proteomic approaches are needed to identify novel alcohol targets and post-translational modifications in airway cilia that are involved in alcohol-dependent signal transduction pathways. When the upper airway fails to clear inhaled pathogens, they enter the alveolar space where they are primarily cleared by alveolar macrophages (AM). With chronic alcohol ingestion, oxidative stress pathways in the AMs are stimulated, thereby impairing AM immune capacity and pathogen clearance. The epidemiology of pneumococcal pneumonia and AUDs is well established, as both increased predisposition and illness severity have been reported. AUD subjects have increased susceptibility to pneumococcal pneumonia infections, which may be due to the pro-inflammatory response of AMs, leading to increased oxidative stress.

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Increased Oxidative DNA Damage in Patients With Alcohol Dependence and Its Correlation With Alcohol Withdrawal Severity

Cited by 45 publications

References 61 publications

Alcohol Dependence in Taiwan: From Epidemiology to Biomedicine

Alcohol Dependence in Taiwan: From Epidemiology to Biomedicine

Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats

Alcohol and lung injury and immunity

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