Increased Permeability of the Blood-Brain Barrier in Lymphostatic Encephalopathy

Várkonyi, Tamás; Joó, Ferenc; Csillik, B.; Zoltán, Ö.T.; Földi, M.

doi:10.1159/000157796

Cited by 3 publications

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“…According to Varkonyi et al [25] the in vasion of the brain by lymph-due proteins in the case of cervical lymph blockade is responsible for the development of the functional and morpho logical brain disturbance. Corresponding to our results, the increased vasopermeability seems to be mediated at least partly by kinins because (1) previous exhaustion of plasma kininogen lowers the permeability for protein-bound dye into the tissue of the brain, and (2) the systemic ampli fication of the kininolytic potential results in the same effect.…”

Section: Discussionmentioning

confidence: 99%

“…The cerebral blood vessels, too, are in volved in this pathophysiological process (lymphostatic hemangiopathy). Within 5 days the blockade of the cervical lymph flow causes edema fol lowed by hemangiopathy with increased permeability of the blood-brain barrier, which reinforces the edema and results in a circulus vitiosus [14,25], In order to find out whether kinins are involved in the increase of vasopermeability in the brain of encéphalopathie rats the extractable amount of Evans blue from brains after i.v. dye injection was estimated.…”

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Kinins – Evidence for the Involvement in Lymphostatic Encephalopathy in Rats

Wendel¹,

Seidel²

1972

Pharmacology

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Five days after blockade of the cervical lymph vessels rats suffer from lymphostatic encephalopathy with impaired central nervous function and cerebral edema. The vascular permeability in the brain for i.v. injected Evans blue is increased. The enhancement of the permeability is suppressed after depletion of kininogen with hog pancreatic kallikrein and cellulose sulphate or by increase of the kinin destroying enzymes (carboxypeptidase B). Trasylol® and SBTI have no effect. Kinins are shown to play a role in a situation with lymphogenic edema.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Kinins – Evidence for the Involvement in Lymphostatic Encephalopathy in Rats

Wendel¹,

Seidel²

1972

Pharmacology

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Permeability of the blood-brain-barrier in lymphostatic encephalopathy combined with complex vitamin B deficiency. The protective effect of vitamin (factor) P treatment

Földi-Börcsök

Földi

1973

Experientia

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Effect of antiphlogistics on blood-brain barrier in lymphostatic encephalopathic and in normal rats

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Seidel

1975

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Injection of the tremorigenic alkaloid harmine into lymphostatic encephalopathic rats leads to a longer duration of tremor and higher brain concentrations than in sham-operated controls. In lymphostatic encephalopathic as well as in normal rats different antiphlogistics shorten the tremor duration and decrease harmine concentration in brain. The antiphlogistics do not influence the plasma concentration of harmine, its protein binding and its tremorend concentration in brain. The effect of antiphlogistics in lymphostatic encephalopathic rats is considered as a consequence of the reduced blood-brain barrier permeability. Obviously in sick animals the blood-brain barrier permeability for harmine is not increased; the prolonged harmine tremor and the increased alkaloid concentration in the brain are consequences of the impaired cerebral lymphatic drainage only.

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Increased Permeability of the Blood-Brain Barrier in Lymphostatic Encephalopathy

Cited by 3 publications

References 2 publications

Kinins – Evidence for the Involvement in Lymphostatic Encephalopathy in Rats

Kinins – Evidence for the Involvement in Lymphostatic Encephalopathy in Rats

Permeability of the blood-brain-barrier in lymphostatic encephalopathy combined with complex vitamin B deficiency. The protective effect of vitamin (factor) P treatment

Effect of antiphlogistics on blood-brain barrier in lymphostatic encephalopathic and in normal rats

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