Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

Maes, Michaël; Mihaylova, Ivanka; Kubera, Marta; Uytterhoeven, Marc; Vrydags, Nicolas; Bosmans, Eugène

doi:10.1016/j.jad.2009.12.014

Cited by 132 publications

(100 citation statements)

References 64 publications

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“…Moreover, besides high O 2 consumption, the brain is highly vulnerable to oxidative damage due to its modest antioxidant defense and a high concentration of highly oxidizable substrate, e.g., lipids. There are some experimental data suggesting that specific changes in these two factors in the brain are leading to an increase of ROS concentration in major depression (49). This is further supported by our finding that CMS-susceptible rats did not show the changes in glutathione concentration in spite of elevated lipid peroxidation.…”

Section: Discussionsupporting

confidence: 86%

“…Accordingly, it has been shown that exposure to repeated and unpredictable stressors increases ROS production in the rat brain (21,47,48,68), which, in turn, results in oxidative damage in the central nervous system. Moreover, studies investigating the oxidative stress profile found a reduction in antioxidant enzymes and elevation of the products of lipid peroxidation in the blood of patients with major depression (5,44,49,56). We have tested an association between oxidative stress and CMS susceptibility by estimating the total concentration of the major antioxidant, glutathione, and a general product of peroxidation of membrane polyunsaturated fatty acids by ROS and MDA.…”

Section: Discussionmentioning

confidence: 99%

“…MDA is a common general product of nonenzymatic peroxidation of polyunsaturated fatty and arachidonic acids. MDA may be increased in major depression (49) and in cardiovascular patients (15,59). Moreover, MDA is considered not only to be a product of lipid peroxidation but also known to be harmful for cell functions (1).…”

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confidence: 99%

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Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Matchkov VV, Kravtsova VV, Wiborg O, Aalkjaer C, Bouzinova EV. Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression. Am J Physiol Regul Integr Comp Physiol 309: R814 -R823, 2015. First published August 12, 2015 doi:10.1152/ajpregu.00337.2014.-Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with Ͼ30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CMS-susceptible and compared with unstressed controls. Sixteen CMS-susceptible and eight unstressed rats were treated during weeks 5 to 8 of the CMS protocol with escitalopram. Escitalopram-treated rats with Ͼ20% recovery in the sucrose consumption during the last 2 wk of treatment were defined as escitalopram responders. Rats that did not reach these criteria were defined as escitalopram nonresponders. In the open field test, escitalopram responders demonstrated anxiolytic effect of treatment. In mesenteric small arteries, escitalopram affected neither NO nor cyclooxygenase-1 (COX-1)-mediated vasodilation. Escitalopram potentiated endothelium-dependent hyperpolarization-like response, which was suppressed in the vehicle-treated CMS-susceptible rats and reduced COX-2-dependent relaxation, which was elevated in the vehicle-treated CMS-susceptible rats. Escitalopram did not affect blood pressure and heart rate, which were elevated in the vehicle-treated CMS-susceptible rats. Oxidative stress markers were changed in association with CMS in liver, heart, and brain. Escitalopram normalized oxidative stress markers in the majority of tissues. This study demonstrates that the antidepressant effect of escitalopram is associated with partial improvement of endothelial function in small arteries affecting COX-2 and endothelium-dependent hyperpolarization-like pathways.depression; chronic mild stress; escitalopram; endothelium; nitric oxide synthase; cyclooxygenase; endothelium-derived hyperpolarization; oxidative stress; glutathione; malondialdehyde CARDIOVASCULAR DISEASES AND major depressive disorder are the two most prevalent health problems in high-income countries (31). Their comorbidity is well recognized, but the mechanisms and critical factors underlying this comorbidity are unknown. Interactions between several factors common for both disorders are complex (17; 43). Thus, a dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and activation of the renin-angiotensin-aldosterone system lead to changes associated with both depression and cardiovascular abnormalities.Also dysfunction of the autonomic nervous system (sympathetic/parasympathetic) is known to be involved, as well as an activation of proinflammatory cytokines (46). Importantly, these factors can induce both depression and ch...

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Matchkov

Кравцова

Wiborg

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Depression is also associated with increased plasma levels of peroxides and xanthine oxidase (Herken et al, 2007, Maes et al, 2010. The efficacy of antioxidant therapies for depression is unknown, although N-acetylcysteine, a powerful antioxidant, was found to be useful for depressive episodes in bipolar disorder (Berk et al, 2008, Magalhaes et al, 2011 and zinc, which serves as a strong antioxidant, also has antidepressant activity (Szewczyk et al, 2011).…”

Section: Oxidative and Nitrosative Stressmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

531

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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“…9,10) Lipid peroxidation has been implicated in the pathogenesis of various diseases, such as coronary heart disease, atherosclerosis, and cancer, as well as the ageing process. [11][12][13][14] Morin has been suggested as an inhibitor of lipid peroxidation. However, the absolute bioavailability of morin after a single oral dose is very low (less than 1%), likely because of its low aqueous solubility, P-glycoprotein (P-gp)-mediated efflux, and low intestinal permeability.…”

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confidence: 99%

Formulation and Evaluation of Morin-Loaded Solid Lipid Nanoparticles

Ikeuchi-Takahashi

Ishihara

Onishi

2016

Biological & Pharmaceutical Bulletin

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In this study, solid lipid nanoparticle (SLN) suspensions were prepared using a base of hard fat with or without ethylcellulose (EC) and polyvinyl alcohols (PVA) and polysorbate (Tween) 60 surfactants. Commercially available PVAs vary in their degree of saponification and polymerization, and the appropriate PVAs to form SLNs from hard fat with or without EC were investigated. A relatively low-saponification-degree PVA was required to reproducibly form SLN suspensions without EC and relatively high-saponification-degree PVAs were suitable for SLNs with EC. The release of morin from SLNs with EC was more sustained than that from SLNs without EC. The maximum plasma concentration (C max ) of SLNs with and without EC were almost the same, and both were higher than that of a morin suspension. The area under the curve for 0 to 360 min (AUC 0-360 ) of SLNs with EC was increased compared with those of a morin suspension and SLNs without EC. The median diameter of SLNs with EC and a very low-saponification-degree PVA was decreased compared to other formulation, and morin release was more sustained for this formulation. SLNs with EC and a very low-saponification-degree PVA showed higher C max and AUC 0-360 than SLNs with EC lacking a very low-saponification-degree PVA. The optimized SLNs with EC and a very low-saponification-degree PVA improved bioavailability via increased accessibility to the enterocyte surface by decreased particle size and increased permeation of SLN encapsulated morin through the intestinal membrane by sustained release properties.Key words solid lipid nanoparticle; polyvinyl alcohol; morin; bioavailability; hard fat Polyphenols are a large and diverse class of compounds that are classified as flavonoids, hydroxycinnamic acids, stilbene derivatives, and polymers. 1) Many polyphenols occur naturally in foods, such as beans, cereals, fruits, vegetables, and red wine.2) The biological properties of polyphenols and their role in preventing or ameliorating diseases related to oxidation is attracting increasing interest. Morin (3,5,7,2′,4′-pentahydroxyflavone) is a flavonoid that has been identified in fruits, vegetables, tea, and many Asian medicinal herbs.3) Morin has a number of potentially useful biological activities, including anti-inflammatory, anticancer, antioxidant, antihypertensive, and anticlastogenic responses. [4][5][6][7][8] Unsaturated fatty acids are the most important structural components of biological membranes and help maintain the fluidity of the cellular membrane structure. The peroxidation of unsaturated fatty acids in biological membranes disrupts their structure and function.9,10) Lipid peroxidation has been implicated in the pathogenesis of various diseases, such as coronary heart disease, atherosclerosis, and cancer, as well as the ageing process. 11-14)Morin has been suggested as an inhibitor of lipid peroxidation. However, the absolute bioavailability of morin after a single oral dose is very low (less than 1%), likely because of its low aqueous solubility, P-glycoprotein (P-gp...

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Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

Cited by 132 publications

References 64 publications

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Formulation and Evaluation of Morin-Loaded Solid Lipid Nanoparticles

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