Increased plasma silicon concentrations and altered bone resorption in response to sodium zeolite a supplementation in yearling horses

Lang, Konrad; Nielsen, B.D.; Waite, K.; Hill, Gary E.; Orth, Michael

doi:10.1016/s0737-0806(01)70161-x

Cited by 15 publications

(23 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous in vivo and in vitro studies have revealed that zeolite can stimulate bone growth [56,57] and its regulation in combination with bone graft substitutes [58]. The porous structure and powder form is the zeolite properties which are the main consideration in its development, however, the corrosion resistance of metals directly influenced by synthesis of the zeolite coating layer on the metal surface [29,30].…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

View full text Add to dashboard Cite

Abstract. This review focuses on the latest reports of the use of zeolites, natural as well as synthetic, as biomedical materials. Discussion on biocompatibility, non-toxicity, zeolite for drug delivery materials, zeolite for bone implants and implant coatings, and the mechanical properties of polymer-zeolite composites are included. The section on the interaction between body tissues and zeolite-based biomaterials focuses on their biocompatibility, non-toxicity, and bioactivity. The next section concerns drug delivering biomaterials. Including delivery of a controlled drug, ionic removal, and synthesized drug delivering materials. The final section concern bone graft substitutes and implant-coating to improve corrosion resistance and osteointegration. The implant material system discussed in a further section is an investigation of the mechanical properties of high-density polyethylene(HDPE)-zeolite composites developed as skull bone implant materials.

show abstract

Section: Drug-delivering Biomaterialsmentioning

confidence: 99%

Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

View full text Add to dashboard Cite

show abstract

“…However, on day 60, the SS plasma silicon concentration had declined to concentrations similar to CO, and lower than day 0. The decrease in silicon concentrations in both groups was unexpected, as plasma silicon concentration increases in horses supplemented with SZA [3,4,7,19]. No explanation can be offered for these results.…”

Section: Discussionmentioning

confidence: 98%

“…Although several studies have reported on the effects of SZA on blood mineral concentrations [2][3][4][5], few, if any, have investigated long term (>14 days) supplementation on mineral retention and digestibility. Additionally, most studies have focused primarily on blood concentrations of calcium, phosphorus, and silicon.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tissue Response to a Supplement High in Aluminum and Silicon

Turner

Nielsen

O′Connor-Robison

et al. 2007

Biol Trace Elem Res

View full text Add to dashboard Cite

The objective was to determine the effects of sodium zeolite A (SZA) on mineral metabolism and tissue mineral composition in calves. Twenty calves were placed on study at 3 days of age and were placed into one of two groups: SS, which received 0.05% BW SZA added to their milk replacer, and CO, which received only milk replacer. Blood samples were taken on days 0, 30, and 60 for mineral analysis. Urine and feces were collected on day 30 for mineral metabolism, and on day 60, the calves were euthanized, and samples were taken from numerous organs for mineral analyses. Aluminum retention was increased in the SS calves (p = 0.001). Silicon concentrations were increased in the aorta, spleen, lung, muscle, and kidney of the SS calves, and aluminum was increased in all SS tissues (p < 0.05). Calcium concentrations were increased in aorta, liver, muscle, and tendon; phosphorus concentrations were increased in aorta, but decreased in plasma; magnesium concentrations were increased in aorta, heart, kidney, liver, and pancreas, but decreased in plasma; and iron concentrations were decreased in kidney and liver (p < 0.05). The accumulation of tissue aluminum and therefore potential adverse consequences may preclude any benefits of using SZA as a dietary supplement.

show abstract

“…Изменение кислотности желудочного содержимого в сторону ее снижения на фоне патологии не может не отразиться на функциональном состоянии желудка и пищеварительной системы в целом (Zhargalov et al, 2005). Изучался эффект добавления биодоступного источника кремния (цеолит А) на изменение костного метаболизма у лошадей (Lang et al, 2001), однако в литературе пока что мало информации об использовании микотоксин-детоксицирующих агентов в исследованиях in vivo с такими видами животных, как лошади. Полимерный глюкоманнан (GM), адсорбирующий микотоксин, был испытан на эффективность в предотвращении микотоксикозов Fusarium (DON + DAS + фузаровой кислоты + ZEA) у лошадей.…”

unclassified

Применение Природного Клиноптилолита В Кормлении Лошадей

Некрасов¹,

Zelenchenkova²,

Чабаев³

et al. 2017

Ukr J Ecol

View full text Add to dashboard Cite

We provided an inclusion of the mineral supplement as clinoptilolite (Nat-Min 9000, fraction 0-1 mm, 70 g per horse/day, NatMin 200, fraction 0-0.2 mm, 28 g per head/day) in the ration of sports horses and this was provided a positive effect on the body of experimental animals as evidenced by data of blood biochemistry. The studied blood values were within the physiological norms, the usage of clinoptilolite led to optimization of the biochemical profile of sports horses. The use of the adsorption additive Nat-Min did not adversely affect the concentration of fat-soluble vitamins A and E in the blood of experimental animals. At the end of the experiment, the concentration of vitamins A and E in the blood of the animals of the 2nd test group were above the control by 0.95 -5.50 μmol/L and by 6.78 -12.09 μmol/L (p < 0.05) in 3rd test group compared to the control. At the same time, the concentration of vitamin B2 in the horse blood of experimental groups decreased by 0.0037 μmol/ml (p <0.05) in 2nd experimental group and 0,0031 μmol/l in 3rd test group. The content of lysozyme in the blood of animals of the 2nd and 3rd test groups has increased relative to the control level by 0.13 and 0.16 μg/ml, respectively. Phagocytic activity in experimental groups has increased relative to control by 1.40%. A positive effect of the Nat-Min feed additive (fractions of 0-1 and 0-0.2 mm) on the physiological processes in the animals was also established. Variations of mineral additive fodder resulted in a generally equivalent positive biological effect, which makes it possible to recommend the use of clinoptilolite for horse feeding. Конноспортивная база ФАУ МО РФ ЦСКА, E-mail: veugeniya@yandex.ruВключение нами в состав рациона кормления спортивных лошадей минеральной добавки клиноптилолита (Nat-Min 9000, фракция 0-1 мм -70 г/гол./сут., Nat-Min 200, фракция 0-0,2 мм -28 г/гол./сут.) обеспечило положительное влияние на организм подопытных животных, о чем свидетельствуют данные по биохимии крови. Изученные показатели крови находились в пределах физиологических норм, а скармливание клиноптилолита приводило к оптимизации биохимического профиля спортивных лошадей. Применение адсорбирующей добавки Nat-Min не оказало отрицательного воздействия на концентрацию жирорастворимых витаминов А и Е в крови подопытных животных. В конце опыта концентрация витаминов А и Е в крови животных 2-й опытной группы была выше контроля на 0,95 -5,50 мкмоль/л и на 6,78 -12,09 мкмоль/л (р < 0,05) в 3-й опытной группе соответственно, по сравнению с контролем. При этом, концентрация в крови витамина В2 снизилась на 0,0037 мкмоль/мл (р < 0,0)5 во 2-й опытной и на 0,0031 мкмоль/л в 3-й опытной группе. Содержание лизоцима в крови животных 2-й и 3-й опытных групп увеличилось относительно уровня контроля на 0,13 и 0,16 мкг/мл соответственно.

show abstract

Increased plasma silicon concentrations and altered bone resorption in response to sodium zeolite a supplementation in yearling horses

Cited by 15 publications

References 14 publications

Zeolite-based biomaterials for biomedical application: A review

Zeolite-based biomaterials for biomedical application: A review

Tissue Response to a Supplement High in Aluminum and Silicon

Применение Природного Клиноптилолита В Кормлении Лошадей

Contact Info

Product

Resources

About