Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow

Turhan, Hasan; Saydam, Gülsevim; Erbay, Ali Rıza; Ayaz, Selime; Yaşar, Ayşe Saatçı; Aksoy, Yüksel; Başar, Nurcan; Yetkın, Ertan

doi:10.1016/j.ijcard.2005.05.008

Cited by 118 publications

(100 citation statements)

References 34 publications

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“…They have also demonstrated that there is significant relationship between CTFC and endothelium-dependent vasodilatation in the brachial artery. In accordance with their findings, more recently; one (Turhan et al 2006) has reported that patients with SCF have elevated levels of circulating plasma soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, they have suggested that endothelial activation or inflammation at microvascular level may play a role in the pathogenesis of slow coronary flow. Previously, Cin and co-workers (Cin et al 2003) demonstrated that the intima-media area was diffusely thickened in given coronary arteries in patients with SCF when viewed with intravascular ultrasound.…”

Section: Discussionsupporting

confidence: 66%

Slow Coronary Flow is Associated with Carotid Artery Dilatation

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Demircan

et al. 2006

Tohoku J. Exp. Med.

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Slow coronary flow (SCF) in a normal coronary angiogram is a wellrecognized clinical entity, but its etiopathogenesis remains unclear. Carotid intima-media thickness (CIMT) is a noninvasive marker of atherosclerosis. The aim of this study was to investigate the CIMT and diameter of carotid and coronary artery in relation to SCF. Twenty-four patients with angiographically diagnosed SCF (51 ± 7 years), and 26 agematched subjects with normal coronary flow (NCF) (52 ± 8 years) in the coronary angiography were enrolled. Coronary flow rates were documented by thrombolysis in myocardial infarction (TIMI) frame count (TFC), a simple method for evaluating coronary blood flow. Carotid and coronary artery diameters and CIMT were measured. Mean TFC was significantly higher in patients with SCF than in patients with NCF ( p < 0.001). There were no significant differences regarding maximum ( p = 0.84) and mean CIMT ( p = 0.61). On the other hand, carotid lumen ( p = 0.03) and coronary artery diameters ( p = 0.001) were significantly greater in patients with SCF than in subjects with NCF. There was a significant relation between mean coronary artery diameter and TFC ( p = 0.004, 95% CI for OR: 1.61-11.87). In conclusion, these findings suggest that CIMT is not altered in patients with SCF as compared with those with NCF. However, carotid and coronary artery diameters are increased in patients with SCF as compared to those with NCF. Because the common carotid artery can be assessed in nearly every patient, carotid artery dilatation may be used as an early indicator for SCF. slow coronary flow; carotid intima-media thickness; carotid artery diameter; coronary artery diameter

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Section: Discussionsupporting

confidence: 66%

Slow Coronary Flow is Associated with Carotid Artery Dilatation

Yiğit

Sezgin

Demircan

et al. 2006

Tohoku J. Exp. Med.

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“…Turhan, et al found that the serum ICAM-1, VCAM-1, and E-selectin concentrations of patients with SCF were significantly higher than those of control subjects with normal coronary flow. 4) Lee, et al reported that the plasma concentration of CRP and IL-6 concentration were increased, and were positively correlated with TIMI frame count in patients with SCF compared with normal coronary flow subjects. Among the inflammatory markers, a large amount of data has indicated that high-sensitive CRP (hsCRP) is a sensitive marker of underlying systemic inflammation and is increased among men and women at risk for future cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Nebivolol on Flow-Mediated Dilation in Patients With Slow Coronary Flow

et al. 2009

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SummarySlow coronary flow (SCF) is the phenomenon of slow progression of angiographic contrast in the coronary arteries in the absence of stenosis in the epicardial vessels in some patients presenting with chest pain. There are no definite treatment modalities for patients with SCF. Our aim was to investigate the efficacy of nebivolol in patients with slow coronary flow by monitoring its effects on endothelial function and different markers of inflammation. Forty-two patients (16 females, 26 males; mean age, 55 ± 10) with slow coronary flow (SCF) were included in the study. After baseline assessment, the patients were administered nebivolol 5 mg once daily. After 12 weeks of nebivolol therapy, the biochemical and ultrasonographic examinations were repeated. Chest pain relief was detected in 38 patients after treatment (90%). Systolic and diastolic blood pressure and high sensitive CRP were significantly decreased after nebivolol therapy. Among brachial artery dilation variables that reflect endothelial function, basal resistive index (RI), post-flow mediated dilation RI, and post-nitrate mediated dilation RI were significantly decreased after therapy. Nebivolol is effective at improving endothelial function in patients with SCF. It controls chest pain, decreases CRP, and has favorable effects on brachial artery dilation variables in patients with coronary slow flow. (Int Heart J 2009; 50: 545-553)

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“…Coronary atherosclerosis, disturbed microvasculariza-tion functions, and endothelial dysfunction were reported to be closely related to CSF [4,5]. It was shown that there is significant relationship between inflammatory markers and coronary flow rate [6,7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tp-Te Interval and Tp-Te/QT Ratio in Patients with Coronary Slow Flow Tp-Te/QT Ratio and Coronary Slow Flow

et al. 2015

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Objective: Coronary slow flow (CSF) phenomenon is described by angiographically normal coronary arteries with delayed opacification of the distal vasculature. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-Te) may correspond to the transmural dispersion of the repolarization and that increased Tp-Te interval and Tp-Te/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate the ventricular repolarization by using Tp-Te interval and Tp-Te/QT ratio in patients with CSF. Materials and Methods:This study included 50 CSF patients (40 male, mean age 48.6±12.5 years) and 40 control individuals (23 male, mean age 47.8±12.5 years). Tp-Te interval and Tp-Te/QT ratio were measured from the 12-lead electrocardiogram. These parameters were compared in groups.Results: Baseline characteristics of the study groups were comparable. In electrocardiographic parameters analysis, QT and corrected QT were similar in CSF patients compared to the controls (357±35.2 vs 362±38.0 milliseconds and 419±25.8 vs 430±44.2 milliseconds, all p value >0.05). Tp-Te interval, Tp-Te/QT and Tp-Te/QTc ratio were significantly higher in CSF patients (85±13.7 vs 74±9.9 milliseconds and 0.24±0.03 vs 0.20±0.02 and 0.20±0.03 vs 0.17±0.02 all p value <0.001). Conclusion

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Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow

Cited by 118 publications

References 34 publications

Slow Coronary Flow is Associated with Carotid Artery Dilatation

Slow Coronary Flow is Associated with Carotid Artery Dilatation

Efficacy of Nebivolol on Flow-Mediated Dilation in Patients With Slow Coronary Flow

Evaluation of Tp-Te Interval and Tp-Te/QT Ratio in Patients with Coronary Slow Flow Tp-Te/QT Ratio and Coronary Slow Flow

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