Increased Plasma Vasopressin and Atrial Natriuretic Peptide in Chronic Schizophrenic Patients during Abdominal Surgery

Kudoh, Akira; Kudo, M; Ishihara, Hironori; Matsuki, Akitomo

doi:10.1159/000026498

Cited by 13 publications

(3 citation statements)

References 21 publications

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“…The fact that the increase in psychotic symptoms was similar in the two groups of patients, and that stress normally has no effect on or suppresses pAVP, suggests that the pAVP responses are not attributable to the stress of psychosis per se (Goldman et al 1997). Other data also suggest that the pAVP response to mixed psychological stress is greater in schizophrenia (Elman and Breier 2002; but see Kudoh et al 1998), although the relationship to HF volume is unknown…”

Section: Candidate Findings In Schizophrenia Suggestive Of Impaired A...mentioning

confidence: 99%

What Is the Functional Significance of Hippocampal Pathology in Schizophrenia?

Goldman¹,

Mitchell²

2004

Schizophrenia Bulletin

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The hippocampal formation (HF) is one of the brain structures most consistently altered in schizophrenia, yet the contribution of HF pathology to severe mental illness is poorly understood. We present evidence that our current ignorance is attributable to the fact that the anterior HF is heavily involved in schizophrenia but has been inadequately examined by schizophrenia investigators. We propose that the anterior HF in humans, and its counterpart in rodents (ventral HF), constrain diverse responses to psychological stimuli and that disruption of this function contributes to schizophrenia. While current data suggest that hallmark symptoms of schizophrenia most likely result from the role of the anterior HF in the integrated neurocircuit that includes the prefrontal cortex, ventral striatum, and ventral tegmental area, better characterized and phylogenetically preserved neurocircuits may be similarly affected by anterior HF pathology and account for associated findings of the disorder. We propose that focusing on the impact of ventral HF pathology on these simpler circuits and functions in rodents may provide insight into the pathophysiology of severe mental illness in humans. We review several associated findings in schizophrenia to assess the likelihood that each could be a product of this putative anterior HF dysfunction and could therefore be productively studied in rodents by probing ventral HF function.

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Section: Candidate Findings In Schizophrenia Suggestive Of Impaired A...mentioning

confidence: 99%

What Is the Functional Significance of Hippocampal Pathology in Schizophrenia?

Goldman¹,

Mitchell²

2004

Schizophrenia Bulletin

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“…Evidence of pathological associations between plasma or CSF levels and schizophrenia has been contradictory. Abnormal increases in plasma AVP concentration have been observed in schizophrenic populations [218,219]. High levels of plasma AVP relative to sodium concentration, a common feature to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), has been reported in schizophrenic patients lead some to postulate the potential involvement of AVP in the pathophysiology of schizophrenia [220][221][222].…”

Section: Psychotic Disordersmentioning

confidence: 99%

The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development

Ring¹

2005

CPD

131

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Arginine vasopressin (AVP) is a cyclic nonapeptide synthesized exclusively by neurosecretory cells of the central nervous system (CNS). Two functionally distinct vasopressinergic systems can be defined based on differences in the sites of action and release of AVP. The peripheral vasopressinergic system encompasses the sites of action for AVP released into peripheral circulation (e.g. vascular smooth muscle, liver, kidney) from nerve terminals in the posterior pituitary. Peripherally circulating AVP is responsible for the classic endocrine functions ascribed to this neurohormone (e.g. vasoconstriction, glycogen metabolism, antidiuresis). The central vasopressinergic system, on the other hand, includes the sites of AVP synthesis and release within the CNS, where AVP acts as a neuromodulator/neurotransmitter regulating an array of CNS-mediated functions (e.g. learning and memory, neuroendocrine reactivity, social behaviors, circadian rhythmicity, thermoregulation, and autonomic function). Historically, pharmaceutical interest has focused on drug development efforts that sought to exploit the peripheral effects of AVP. Evidence, however, from clinical studies and animal models of CNS disorders has directly implicated disturbances in vasopressinergic activity in the pathophysiology of a number of human psychiatric disorders (mood, anxiety, and cognitive disorders). This review will examine the available evidence of central vasopressinergic system involvement in psychiatric disorders, and the potential opportunities for development of novel psychopharmaceuticals around this system will be discussed. Specific lines of evidence will be presented which rationalize each AVP receptor subtype (V(1)R or V(1a), V(2)R, V(3)R or V(1b)) as a molecular target for particular psychiatric indications.

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“…In a study aiming to inves-tigate imbalanced water homeostasis in patients with schizophrenia, volume-regulatory hormones were measured during abdominal surgery. The concentrations of plasma aldosterone in response to surgery were significantly lower in chronically antipsychotic-treated patients compared to subjects in the control group [104].…”

Section: Antipsychotic Drugs Lithium and Aldosterone Releasementioning

confidence: 69%

Psychotropic Drug Effects on Steroid Stress Hormone Release and Possible Mechanisms Involved

Romanova

Hlavacova

Ježová

2022

IJMS

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There is no doubt that chronic stress accompanied by adrenocortical stress hormone release affects the development and treatment outcome of several mental disorders. Less attention has been paid to the effects of psychotropic drugs on adrenocortical steroids, particularly in clinical studies. This review focuses on the knowledge related to the possible modulation of cortisol and aldosterone secretion under non-stress and stress conditions by antipsychotic drugs, which are being used in the treatment of several psychotic and affective disorders. The molecular mechanisms by which antipsychotic drugs may influence steroid stress hormones include the modulation of central and/or adrenocortical dopamine and serotonin receptors, modulation of inflammatory cytokines, influence on regulatory mechanisms in the central part of the hypothalamic-pituitary axis, inhibition of corticotropin-releasing hormone gene promoters, influencing glucocorticoid receptor-mediated gene transcription, indirect effects via prolactin release, alteration of signaling pathways of glucocorticoid and mineralocorticoid actions. Clinical studies performed in healthy subjects, patients with psychosis, and patients with bipolar disorder suggest that single and repeated antipsychotic treatments either reduce cortisol concentrations or do not affect its secretion. A single and potentially long-term treatment with dopamine receptor antagonists, including antipsychotics, has a stimulatory action on aldosterone release.

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Increased Plasma Vasopressin and Atrial Natriuretic Peptide in Chronic Schizophrenic Patients during Abdominal Surgery

Cited by 13 publications

References 21 publications

What Is the Functional Significance of Hippocampal Pathology in Schizophrenia?

What Is the Functional Significance of Hippocampal Pathology in Schizophrenia?

The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development

Psychotropic Drug Effects on Steroid Stress Hormone Release and Possible Mechanisms Involved

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