Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens.

Schaft, Theo L. van der; Mooy, Cornelia M.; Bruijn, W. C. de; Mulder, Paul; Pameyer, Jan H.; Jong, P.T.V.M. de

doi:10.1136/bjo.78.6.441

Cited by 96 publications

(52 citation statements)

References 24 publications

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“…Possible mechanisms include retinal inflammatory changes associated with surgery, 10,37 increased light exposure after removal of the lens, 7 and a postoperative biochemical environment in operated eyes (increased free radicals or growth factors), 7,10,38 which could accelerate ARM progression.…”

Section: Discussionmentioning

confidence: 99%

“…Although earlier case series [6][7][8][9] and a postmortem study 10 suggested a possible association between aphakia or pseudo-phakia and late ARM, the evidence from these studies is relatively weak. Findings from large population-based studies 11,12 appeared to support an association between prior cataract surgery and an increase in late ARM prevalence.…”

Section: Introductionmentioning

confidence: 95%

“…The strongest evidence to date, came from a pooled data analysis of two large populationbased studies, 13 that showed a significantly increased 5-year incidence of late ARM (odds ratio (OR) 5.7, 95% confidence interval (CI) 2.4-13.6) in nonphakic (aphakic or pseudo-phakic) eyes compared to phakic eyes, after accounting for age, smoking, and the presence and severity of early ARM lesions at baseline. 13 The Beaver Dam Eye Study (BDES) has reported a significant association between cataract surgery performed prior to baseline and the incidence of late ARM after both [5][6][7][8][9][10][11][12][13][14] and 10-year 15 intervals. The potential for an increased late ARM risk after cataract surgery remains topical and controversial, as indicated by two recent editorials published in Archives of Ophthalmology.…”

Section: Introductionmentioning

confidence: 99%

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Early age-related maculopathy in eyes after cataract surgery

Pham

Cugati

Rochtchina

et al. 2006

Eye

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Purpose To assess age-related maculopathy (ARM) in eyes of patients who had undergone cataract surgery for at least a year. Methods Consecutive patients aged 60 þ years who had undergone cataract surgery at Westmead Hospital, Sydney, Australia, during 2001-2003 were examined in 2004. Interview using standardized questionnaires and stereo retinal photography was performed. Retinal photographs were graded using the Wisconsin ARM grading system. The proportions with ARM were compared between surgical and nonsurgical eyes, and between this surgical cohort and the Blue Mountains Eye Study (BMES) population. Results Of the 622 eligible patients, 454 (73%) were re-examined, with a mean followperiod of 2.8 years. Surgical eyes had a higher proportion of early ARM compared to nonsurgical eyes (15.2 vs 10.3%, P ¼ 0.07) and to the early ARM prevalence found in BMES participants of similar age (14.5 vs 6.9%, Po0.01), which persisted after age standardization to the BMES population (9.7 vs 6.9%, Po0.05). Conclusions We found an increased prevalence of early ARM in surgical eyes of patients 1-3 years after cataract surgery. Whether this increased early ARM prevalence leads to an increased prevalence of late ARM in the long-term warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Early age-related maculopathy in eyes after cataract surgery

Pham

Cugati

Rochtchina

et al. 2006

Eye

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“…In pseudophakic eyes with clear artificial lenses, blue sensitive cones are the first photoreceptors, which decrease in number -due to specific light damage (Werner et al, 1989). Moreover, in histopathological sections of ARMD eyes a higher incidence of severe stages of ARMD was observed (van der Schaft et al, 1994).…”

Section: Evidence Of Light Damage In Epidemiological Studiesmentioning

confidence: 99%

Oxidative Stress Induced Damage of the Human Retina: Overview of Mechanisms and Preventional Strategies

Engelmann¹,

Becker²,

Funk³

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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“…Two developed choroidal neovascularisation following the cataract extraction; however, it is still not clear whether these cases represent complications of surgery [28][29][30] or the underlying progressive nature of the disease. Demoninators vary owing to missing data.…”

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confidence: 99%

Do patients with age related maculopathy and cataract benefit from cataract surgery?

AMBRECHT¹,

FINDLAY²,

ASPINALL³

et al. 1999

British Journal of Ophthalmology

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Aims-To assess the benefits of cataract extraction in patients with age related maculopathy (ARM). Methods-1073 randomly selected cataract operations were reviewed and 99 cases of preoperatively recognised ARM were identified for investigation. Data relating to visual function were retrieved from case notes, and patient responses to a questionnaire were analysed. Results-98% had dry or unspecified ARM. Only 2% had exudative maculopathy. 81% of cases had an improvement in best distance acuity; mean change 0.44 logMAR (change of 6/36 to 6/12). 65% responded to the questionnaire; 67% felt that the operation had been worthwhile, 17% had mixed feelings, and 17% thought it not worthwhile. Conclusion-This study, which is the first of its kind to be reported, shows a clear benefit from cataract surgery in the majority of patients with ARM. However, the prevalence of ARM in this study is lower than expected, suggesting that some patients with both ARM and cataract were not listed for surgery. The design of a prospective study to quantify the subjective and objective benefits of cataract surgery in these patients is outlined and predictors of successful outcome identified. This will promote the development of guidelines for the surgical management of this group of patients. (Br J Ophthalmol 1998;82:611-616) Age related maculopathy (ARM) aVects approximately 40% of those over the age of 75 years.1 2 It is the most common maculopathy to aVect individuals with cataract, the two conditions occurring with increasing frequency with age.3 4 ARM currently contributes to around 50% of all those registered as blind and partially sighted in England and Wales 5 and a recent study has suggested that the condition may be becoming more prevalent. Although this proportion is rather lower than would be expected from prevalence data, this still constitutes around 100 000 operations in the USA and 10 000 operations in the UK each year. When treating a patient with ARM and cataract the clinician must decide whether cataract surgery will be of benefit, a decision that is often diYcult to make. Sometimes the patient is listed for surgery on the grounds that there is little to lose. However, the constraints of tight budgets and waiting lists, and the need to target resources, means that medical practice must be evidence based and it is therefore necessary to have reliable data to support the decision of whether or not to operate.Although previous investigators have identified factors associated with poor outcome following cataract surgery, including the patient age and ocular co-morbidity (especially ARM), 9-16 none has addressed specifically the benefits of surgery in these high risk groups.We have performed a retrospective analysis of case notes and circulated a self completion questionnaire in order to determine whether patients with ARM benefit from cataract surgery both in terms of visual function and patient satisfaction. In addition, we attempted to identify predictors of benefit and to determine whether we are operating on ap...

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Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens.

Cited by 96 publications

References 24 publications

Early age-related maculopathy in eyes after cataract surgery

Early age-related maculopathy in eyes after cataract surgery

Oxidative Stress Induced Damage of the Human Retina: Overview of Mechanisms and Preventional Strategies

Do patients with age related maculopathy and cataract benefit from cataract surgery?

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