Oxidative Stress Induced Damage of the Human Retina: Overview of Mechanisms and Preventional Strategies

Engelmann, Katrin; Becker, K. A.; Funk, Richard

doi:10.5772/33602

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…Cataract surgery influences the intraocular balance in different aspects. It is one of the well-known sources of free radicals [ 2 – 6 ], and it also causes a medium termed lowering of the antioxidative substances in the anterior chamber [ 7 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Visual Acuity, Retinal Sensitivity, and Macular Thickness Changes in Diabetic Patients without Diabetic Retinopathy after Cataract Surgery

Pukl

Valentinčič

Urbančič

et al. 2017

Journal of Diabetes Research

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Aim. Functional and morphological macular study after cataract surgery in a group of diabetics without diabetic retinopathy compared to nondiabetics to evaluate the effect of surgical oxidative stress on diabetic retina. Methods. Prospective, comparative study. Preoperative eye exam, best corrected visual acuity (BCVA) measured by ETDRS letters, and optical coherence tomography (OCT) were followed by standard cataract surgery. The follow-up visits at 1, 3, and 6 months postoperatively included BCVA, OCT, and microperimetry, to analyze changes within and between the groups. Results. The BCVA improved significantly in diabetics and controls: 64.2 to 81.0 and 61.9 to 82.1 ETDRS at 6 months, respectively. The central macula at OCT significantly thickened in both groups, while the central 5 fields, corresponding to the microperimetry area, subclinically thickened from 284.20 to 291.18 μm at 6 months only in diabetics (p = 0.026). A matching slight decrease in the microperimetry sensitivity from 1 to 6 months was found also only in diabetics, with mean average difference −0.75 dB (p = 0.04). Conclusion. Underlying diabetes does not influence the surgical outcome in diabetics without diabetic retinopathy. However, slight thickening of wider macula and corresponding decrease in retinal sensitivity observed in diabetics 6 months postoperatively might influence visual function on long term.

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Section: Introductionmentioning

confidence: 99%

Visual Acuity, Retinal Sensitivity, and Macular Thickness Changes in Diabetic Patients without Diabetic Retinopathy after Cataract Surgery

Pukl

Valentinčič

Urbančič

et al. 2017

Journal of Diabetes Research

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“…Since sunlight exposure [1][2][3] and inflammation [4,5] represent proposed risk factors for agerelated macular degeneration (AMD) pathogenesis, cataract surgery has a theoretic potential to accelerate AMD disease progression. Retrospective studies show that good peri-operative control of exudative AMD is feasible [6,7]; however, the possibility remains that increased light exposure during and after removal of the cataractous lens [8] and/or surgically-induced inflammation causes retinal and retinal pigment epithelium (RPE) damage that may worsen AMD.…”

Section: Introductionmentioning

confidence: 99%

No association between cataract surgery and mitochondrial DNA damage with age-related macular degeneration in human donor eyes

et al. 2021

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Purpose To determine whether age-related macular degeneration (AMD) severity or the frequency of retinal pigment epithelium mitochondrial DNA lesions differ in human donor eyes that have undergone cataract surgery compared to phakic eyes. Methods Eyes from human donors aged ≥ 55 years were obtained from the Minnesota Lions Eye Bank. Cataract surgery status was obtained from history provided to Eye Bank personnel by family members at the time of tissue procurement. Donor eyes were graded for AMD severity using the Minnesota Grading System. Quantitative PCR was performed on DNA isolated from macular punches of retinal pigment epithelium to quantitate the frequency of mitochondrial DNA lesions in the donor tissue. Univariable and multivariable analyses were performed to evaluate for associations between (1) cataract surgery and AMD severity and (2) cataract surgery and mitochondrial DNA lesion frequency. Results A total of 157 subjects qualified for study inclusion. Multivariable analysis with age, sex, smoking status, and cataract surgery status showed that only age was associated with AMD grade. Multivariable analysis with age, sex, smoking status, and cataract surgery status showed that none of these factors were associated with retinal pigment epithelium mitochondrial DNA lesion frequency. Conclusions In this study of human donor eyes, neither retinal pigment epithelium mitochondrial DNA damage nor the stage of AMD severity are independently associated with cataract surgery after adjusting for other AMD risk factors. These new pathologic and molecular findings provide evidence against a relationship between cataract surgery and AMD progression and support the idea that cataract surgery is safe in the setting of AMD.

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Oxidative Stress Induced Damage of the Human Retina: Overview of Mechanisms and Preventional Strategies

Cited by 2 publications

References 104 publications

Visual Acuity, Retinal Sensitivity, and Macular Thickness Changes in Diabetic Patients without Diabetic Retinopathy after Cataract Surgery

Visual Acuity, Retinal Sensitivity, and Macular Thickness Changes in Diabetic Patients without Diabetic Retinopathy after Cataract Surgery

No association between cataract surgery and mitochondrial DNA damage with age-related macular degeneration in human donor eyes

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