Increased Prevalence of Glycoprotein IIb/IIIa Leu33Pro Polymorphism in Term Infants with Grade I Intracranial Haemorrhage

Abstract

The prevalence rates of the platelet glycoprotein IIb/IIIa Leu33Pro allele (PLA2), and factor V G1691A Leiden mutation were determined in 109 appropriate for gestational age neonates with grade I intraventricular haemorrhage (IVH) and in 118 IVH-free control infants. The PLA2 allele frequency was 16.4 % in the group of full-term infants with grade I IVH, while it was 9.5 % in the relevant controls (p < 0.005); there was no difference in the PLA allele frequencies on comparing the IVH affected (8.34 %) and unaffected (9.2 %) premature infants. By contrast, the factor V Leiden allele frequency was increased only in the subgroup of premature infants with grade I IVH as compared with the appropriate premature controls (9.25 % vs. 3.34 %, respectively, p < 0.005). These data suggest that besides the factor V Leiden mutation, the PLA2 allele, which has already been suggested to have a role in neonatal alloimmune thrombocytopenia and certain subtypes of adult stroke, can have significance in the development of the events of IVH.

Red blood cell transfusion of preterm neonates with a Grade 1 intraventricular hemorrhage is associated with extension to a Grade 3 or 4 hemorrhage

“…Some of the variables associated with the extension of an IVH cannot be changed after birth. These include gestational age, birth weight, genetic factors, and cord pH 19‐24 . Unlike these, perhaps other variables are amenable to control by the medical caregivers.…”

Replication of Genetic Associations in the Inflammation, Complement, and Coagulation Pathways With Intraventricular Hemorrhage in LBW Preterm Neonates

“…The coagulation factor V ( FV ) Leiden mutation (rs6025), a coagulation factor II ( FII ) prothrombin polymorphism (G20210A, rs1799963) and a coagulation factor XIII ( FXIII ) missense mutation (Val34Leu, rs5985) have been implicated in several studies as risk factors for the development of IVH (12,14,15,21,22). Additionally, two genes integrin beta-3 ( ITGB3 ) and estrogen receptor-alpha ( ESR1 ) have been associated with IVH (13,23). However, many of these associations have not been tested in multiple independent populations or have not consistently replicated across studies.…”