Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly Obese Patients Candidate for Bariatric Surgery

Schneck, Anne Sophie; Anty, Rodolphe; Tran, Albert; Hastier, Audrey; Amor, Imed Ben; Gugenheim, Jean; Iannelli, Antonio; Piche, Thierry

doi:10.1007/s11695-015-1907-0

Cited by 32 publications

(41 citation statements)

References 27 publications

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“…The association between IBS and self-reported psychiatric disorders is in accordance with studies in patients with morbid obesity and in the general population [7, 8, 14], patients with morbid obesity are known to have higher levels of stress, anxiety, and depression [15]. Associations between IBS and vitamin B 6 deficiency [18, 19] and low-grade systemic inflammation measured as CRP [16, 17] were not seen in this study.…”

Section: Discussionsupporting

confidence: 88%

“…At IHT-G, the prevalence (27%) was three-fold that in the general population from the same region [14]. A high prevalence of IBS is consistent with most other reports from obesity centres [8–10]. …”

Section: Discussionsupporting

confidence: 83%

“…Blood lipoprotein levels are mainly regulated by the hepatocytes. Non-alcoholic fatty liver disease, which could influence the function of hepatocytes, is strongly related to obesity and has been discussed in relation to IBS [8, 28, 29]. Data on fatty liver disease were not available.…”

Section: Discussionmentioning

confidence: 99%

“…Most reports indicate that IBS is more common in patients with morbid obesity than in the general population, with prevalence rates from 8 to 31% in small series [8–12]. The reason for this association is unknown [13].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

et al. 2017

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BackgroundIrritable bowel syndrome has been reported as more common in patients with morbid obesity than in the general population. The reason for this association is unknown. The aims of this study were to study the prevalence of irritable bowel syndrome and other functional bowel disorders in patients with morbid obesity, and to search for predictors of irritable bowel syndrome.MethodsPatients opting for bariatric surgery at two obesity centers in South-Eastern Norway were included. Functional bowel disorders were diagnosed according to the Rome III criteria. Predictors were evaluated in a multivariable logistic regression analysis with irritable bowel syndrome as the dependent variable.ResultsA total of 350 (58%) out of 603 consecutive patients were included. The prevalence rates of irritable bowel syndrome at the two centers were 17/211 (8%) and 37/139 (27%) respectively. High low-density lipoprotein (OR 2.10; 95% CI 1.34–3.29), self-reported psychiatric disorders (OR 2.39; 95% CI 1.12–5.08) and center (OR 5.22; 95% CI 2.48–10.99) were independent predictors of irritable bowel syndrome.ConclusionsAt one of the two obesity centers, the prevalence of irritable bowel syndrome was threefold higher than in the general population in the same region. The high prevalence appears to be related to dietary differences or altered absorption or metabolism of fat. Attention to irritable bowel syndrome is important in the care of patients with morbid obesity.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

et al. 2017

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“…1,4,9 Animal studies have demonstrated the influence of stress on colonic permeability, and mucosal and systemic inflammation's mediation by the autonomic nervous system and the hypothalamo-pituitary-adrenal axis. 4 Several recently published studies have mapped IBS's relationship with psychological disorders [10][11][12][13][14][15][16] and compared depression and anxiety levels in IBS-subtypes. 15,17,18 However, the relationship between IBS and psychological disorders (depression or anxiety) was inconsistent, even in a recent meta-analysis entailing eight studies.…”

Section: Introductionmentioning

confidence: 99%

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

178

151

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Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes. ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.

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European guideline on obesity care in patients with gastrointestinal and liver diseases – Joint European Society for Clinical Nutrition and Metabolism / United European Gastroenterology guideline

et al. 2022

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Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly Obese Patients Candidate for Bariatric Surgery

Abstract: Thirty percent of obese patients had IBS: its severity was not correlated with BMI. However, anxiety was independently associated with IBS, suggesting that psychological factors are key features of IBS, whatever the presence of obesity.

Cited by 32 publications

References 27 publications

Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

European guideline on obesity care in patients with gastrointestinal and liver diseases – Joint European Society for Clinical Nutrition and Metabolism / United European Gastroenterology guideline

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