Increased prevalence of JC polyomavirus in cervical carcinomas from women infected with HIV

Abstract

Although subclinical persistent infections with the human polyomaviruses BKV and JCV are ubiquitous worldwide, these are known to vary in relation to diseases present and geographical location. DNAs from 220 cervical smears and 109 invasive cervical carcinomas obtained from HIV positive and HIV negative Kenyan women of known HPV status were analyzed by nested endpoint PCR for BKV and JCV. BKV-JCV DNA was detected in 5/105 (4.7%) of cervical smears and in 6/37 (16%) of cervical carcinomas from women infected with HIV whereas 9/115 (7.8%) of the cervical smears and 4/72 (5.5%) of the carcinomas were positive in HIV negative women. Nested PCR showed that all 24 samples were positive for JCV and not BKV. JCV was not more prevalent in either HPV positive (P = 0.438) or HPV negative women (P = 0.392). However, 37% of carcinomas and smears which were positive for JCV were also positive for a "high-risk" oncogenic HPV. Comparison of the incidence of JCV in cervical smears and cervical carcinomas showed a ∼3-fold increase in samples from HIV positive women with cervical carcinoma (P = 0.025) whereas no significant difference was found between cervical smears and cervical carcinomas from HIV negative women (P = 0.553). These results suggest that JCV may combine with high-risk HPV infection in women infected with HIV to influence the rate of progression to invasive cervical carcinoma.

Polyomaviruses detectable in head and neck carcinomas

“…A recent review showed that co-infections of HPyV and oncogenic HPVs are not infrequent [ 39 ]. This is particularly true in anal cancer and high-grade cervical intraepithelial lesions (CIN) [ 40 ]. In the present study, both SV40 and JCV were frequently found in concert with HPV.…”

“…Comar and coworkers [ 32 ] reported JCV in 7% of the high-grade CIN but not in normal cervical samples. Alosaimi et al [ 40 ] found 3-fold higher JCV frequency in cervical cancers than in normal cervical smears among HIV-positive women. This suggests a role of JCV in cervical cancer in HIV-co-infected, immunosuppressed patients.…”

The interaction between human papillomavirus and other viruses

“…However, JCV infection did not correlate with HPV infection (Alosaimi et al, 2014; Comar et al, 2011); In contrast, JCV detection was three-fold higher in cervical carcinomas versus normal cervical smears among HIV-positive women, suggesting a role for JCV in cervical cancer in the context of HIV co-infection and immunosuppression (Alosaimi et al, 2014). …”

Detección de polyomavirus BK y JC en extractos leucocitarios de sangre periférica de pacientes con infección por VIH del área norte de Santiago

“…Sólo el año 2014 fue posible encontrar en Medline reportes con cinco protocolos distintos para la detección de estos polyomavirus en muestras clínicas [24][25][26][27][28] . Esto se debe a que existe una importante diversidad de secuencias y no se ha establecido regiones conservadas absolutas.…”