Increased Prevalence of Reduced Estimated Glomerular Filtration Rate in Chronic Hepatitis C Patients

Petre, Sorin; Sachdev, Mankanwal S.; Noble, Brie N.; Rosati, Marianne J.; Mazur, Marek; Heilman, Raymond L.; Harrison, M. Edwyn; Douglas, David D.; Balan, Vijayan

doi:10.1007/s10620-010-1170-0

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…However, whether worsened metabolic risk profile is a consequence of HCV infection or involves the progression of CKD need to be clarified by further studies. Hypertension is known to contribute to an increase in GFR and impaired renal function in patients with HCV infection . The results of studies investigating the association between alcohol consumption and CKD have been conflicting .…”

Section: Discussionmentioning

confidence: 99%

Age and gender differences in the relationship between hepatitis C infection and all stages of Chronic kidney disease

Lee

Chen

et al. 2013

Journal of Viral Hepatitis

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Chronic kidney disease (CKD) is a worldwide health issue with heavy economic burden. Chronic hepatitis C virus (HCV) infection is a common cause of CKD, which can significantly impact the progression and mortality among patients with CKD. The prevalence of both illnesses is high in Taiwan. A multicentre and population-based cross-sectional study including 24 642 subjects was conducted to explore the association of HCV infection with the prevalence and severity of CKD. The measurements of metabolic parameters, eGFR and CKD stages were compared between subjects with HCV seropositivity and seronegativity. The analyses of association between HCV infection with CKD stages and evaluation of potential risk factors of CKD were performed by gender and age (≤ and >45 years). HCV-seropositive subjects accounted for 6.9% and had a significantly older age. The prevalence of CKD increased in those with HCV seropositivity (16.5%). Significantly higher prevalence of CKD stages ≥3 in HCV-seropositive subjects was noticed (7.8%). Age (>45 year), male gender, alcohol drinking, hypertension, creatinine and HCV infection were the significant factors associated with the presence of CKD. HCV seropositivity was an independent risk factor of developing CKD and associated with an increased risk of having CKD of all stages. The higher prevalence of earlier stage of CKD warrants longitudinal studies with frequent testing on renal function and sufficient duration to determine the changes of eGFR over time. Implementation of effective treatment intervention is also required for these subjects to prevent the progression of CKD to late stages.

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Section: Discussionmentioning

confidence: 99%

Age and gender differences in the relationship between hepatitis C infection and all stages of Chronic kidney disease

Lee

Chen

et al. 2013

Journal of Viral Hepatitis

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“…Further, the threshold for considering a value ''abnormal'' varies among clinical laboratories. For example, a serum creatinine concentration was considered abnormal when [1.4 mg/dl in the clinical laboratory used by Petre et al [1]. Many other laboratories, including ours, report concentrations [1.2 mg/dl as abnormal values.…”

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confidence: 97%

“…The benefits of early detection include earlier treatment and patient education, so that co-morbidities associated with CKD can be prevented, and progression to end-state kidney disease can be slowed down. This is particularly relevant to chronic disease states that are known to be associated with CKD, such as chronic hepatitis C. In the manuscript titled ''Increased prevalence of reduced estimated glomerular filtration rate in chronic hepatitis C'' by Petre et al [1], the authors analyzed a cohort of 831 consecutive patients in the outpatient clinic with chronic hepatitis C to assess the prevalence of reduced estimated glomerular filtration (eGFR). The authors reported that more than half of patients had depressed eGFR, with a predominance of patients (36.4%) in the GFR range of stage 2 CKD (60-89 ml/min/1.73 m 2 ).…”

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confidence: 99%

“…Nonetheless, prediction of GFR based on a single equation with a single creatinine measurement in the normal range of GFR, will continue to have its limitations. Adapted from K/DOQI clinical practice guidelines [4] The study population in the article by Petre et al [1] shows that the difference in prevalence of CKD between the aMDRD and Cockcroft-Gault equations are explained by the increased proportion of subjects that fall into the stage 2 CKD range (60-89 ml/min/1.73 m 2 ). This is consistent with the above-mentioned studies that show underestimation of true GFR of C60 ml/min/1.73 m 2 by aMDRD.…”

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confidence: 99%

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Chronic Hepatitis C and Chronic Kidney Disease

Tan

2010

Dig Dis Sci

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“…For instance, on one hand, CHC is associated with essential mixed cryoglobulinaemia (MC) leading to membranoproliferative glomerulonephritis (MPGN) (6), and on the other, patients with CKD have an increased risk of infection because of prolonged use of vascular access and the frequent exposure to contaminated medical equipment. As a result, CHC reflects the most common chronic liver disease in patients with end‐stage renal disease (ESRD) (7, 8) and consists a significant cause of mortality among HD and kidney transplant patients (9). This review aims to present key data on the association of CHC and CKD.…”

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confidence: 99%

Hepatitis C virus and kidney: a strong association with different clinical aspects

Pipili

Ilonidis

2011

Liver International

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The most frequent kidney disease associated with chronic hepatitis C virus (HCV) infection is membranoproliferative glomerulonephritis in patients with type II mixed cryoglobulinaemia. The principal clinical manifestations of glomerular disease in HCV-infected patients are the presence of proteinuria and haematuria with or without impaired kidney function. Pharmaceutical regimens vary because the main pathogenesis of renal dysfunction often mediated by cryoglobulins has not been fully elucidated. HCV infection remains common in patients on renal replacement therapy and has an adverse impact on their survival. Safe and effective pharmaceutical regimens have not been yet established and nosocomial spread within dialysis units continues to occur. Monotherapy with interferon for HCV infection is probably more effective in dialysis than in non-uraemic patients, while experience with ribavirin is limited because of its adverse haemolytic effect. Based on shortage of cadaver kidneys and the fact that HCV renal transplant recipients have better survival than stay on maintenance haemodialysis or at list for transplantation, health organization proposed the use of cadaver kidneys from anti-HCV-positive donors, bringing up concerns and conflicting views. This present review describes the main renal manifestations of HCV infection, the epidemiological and clinical characteristics of chronic kidney disease population and comments on the limitations and shortcomings of current therapeutical regiments.

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Increased Prevalence of Reduced Estimated Glomerular Filtration Rate in Chronic Hepatitis C Patients

Cited by 4 publications

References 29 publications

Age and gender differences in the relationship between hepatitis C infection and all stages of Chronic kidney disease

Age and gender differences in the relationship between hepatitis C infection and all stages of Chronic kidney disease

Chronic Hepatitis C and Chronic Kidney Disease

Hepatitis C virus and kidney: a strong association with different clinical aspects

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