Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease

Lo, Joan C.; Chertow, Glenn M.; Go, Alan S.; Hsu, Chi-yuan

doi:10.1111/j.1523-1755.2005.00169.x

Cited by 311 publications

(302 citation statements)

References 22 publications

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“…Interestingly, CKD was found to be associated with a greater prevalence of clinical and subclinical primary hypothyroidism among participants of the Third National Health and Nutrition Examination Survey (4). Recently, we extended these findings in a large non-US cohort of outpatients by showing that the prevalence of subclinical hypothyroidism increases as estimated glomerular filtration rate (eGFR) decreases (5).…”

Section: Introductionmentioning

confidence: 50%

Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis

Targher

Chonchol

Zoppini

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: The prevalence of thyroid autoimmunity and subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined. Methods: We studied 1000 consecutive adult outpatients who were referred by their general practitioner for blood testing over the last 2 years. We excluded those with abnormal serum free thyroxine (FT4) levels (ns85). No participants required chronic renal replacement therapy. Thyroid autoimmunity was defined as increased concentrations of serum anti-thyroid antibodies. Subclinical primary hypothyroidism was defined as a serum thyrotropin (TSH) concentration

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Section: Introductionmentioning

confidence: 50%

Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis

Targher

Chonchol

Zoppini

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…In humans, subclinical hypothyroidism is associated with cardiac dysfunction, atherosclerosis, and hypercholesterolemia 36, 37, 44. Interestingly, there also appears to be an increased prevalence of subclinical hypothyroidism in people with CKD 45. A recent study of subclinical hypothyroidism and CKD found that human patients receiving L‐T 4 supplementation had slower declines in GFR and were less likely to develop end‐stage CKD than those receiving a placebo 46.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Low‐dose (2 millicurie) versus Standard‐dose (4 millicurie) Radioiodine Treatment for Cats with Mild‐to‐Moderate Hyperthyroidism

Lucy

Peterson

Randolph

et al. 2017

Veterinary Internal Medicne

127

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BackgroundRadioiodine (131I) is effective treatment for hyperthyroidism in cats, but optimal dose to restore euthyroidism without inducing hypothyroidism is unclear. Treatment‐induced hypothyroidism can lead to azotemia and reduced duration of survival.ObjectiveTo compare efficacy and short‐term outcomes of low‐dose 131I versus higher, standard‐dose 131I as treatment for hyperthyroidism.AnimalsA total of 189 client‐owned cats undergoing 131I treatment for mild‐to‐moderate hyperthyroidism (serum T4 ≥ 4.0 μg/dL and <13.0 μg/dL).MethodsProspective, nonrandomized, cohort study comparing treatment with either low‐dose (2 mCi, n = 150) or standard‐dose (4 mCi, n = 39) 131I. Serum T4, thyroid‐stimulating hormone (TSH), and creatinine concentrations were measured after 1, 3, and 6 months to determine persistent hyperthyroidism, overt hypothyroidism (low T4, high TSH), subclinical hypothyroidism (normal T4, high TSH), and azotemia.ResultsThere was no significant difference in prevalence of cats with persistent hyperthyroidism between standard‐ and low‐dose treatment groups at 3 (0% versus 5.3%; P = .34) and 6 (0% versus 3.3%; P = .51) months. Overt (18% versus 1%; P = .0005) or subclinical (46% versus 21%; P = .004) hypothyroidism was more common in cats at 6 months after standard‐dose 131I. No difference in incidence of azotemia existed between groups, but cats treated with standard‐dose 131I had higher creatinine concentrations (P < .05) and higher percent rises in creatinine (P < .0001).Conclusions and Clinical ImportanceLow‐dose 131I is safe and effective for cats with mild‐to‐moderate hyperthyroidism, as evidenced by a cure rate of >95% with reduced frequency of iatrogenic hypothyroidism and azotemia.

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“…The analysis of the third national survey in the United States revealed, that among patients with chronic kidney disease, the prevalence of hypothyroidism increases with lower levels of glomerulus filtration rate (GFR), in subjects with GFR <30 ml/min/1.73m 2 the prevalence was 23.1% [11]. In another cross-sectional analysis in Italy, the prevalence of subclinical hypothyroidism was found to be 17.9% in persons with GFR <60 ml/min/1.73m 2 [12].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis

Paudel¹

2014

JCDR

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Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease

Cited by 311 publications

References 22 publications

Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis

Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis

Efficacy of Low‐dose (2 millicurie) versus Standard‐dose (4 millicurie) Radioiodine Treatment for Cats with Mild‐to‐Moderate Hyperthyroidism

Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis

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