Increased Primary Non-Function in Transplanted Deceased-Donor Kidneys Flushed with Histidine-Tryptophan-Ketoglutarate Solution

Stevens, R. Brian; Skorupa, Jill Y.; Rigley, Theodore H.; Yannam, Govardhana Rao; Nielsen, Kathleen J.; Schriner, Megan; Skorupa, Anna; Murante, A.; Holdaway, E.; Wrenshall, Lucile E.

doi:10.1111/j.1600-6143.2009.02624.x

Cited by 30 publications

(20 citation statements)

References 49 publications

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“…However, HTK has replaced UW solution at many centers because of better tissue perfusion due to a lower viscosity, a reduced risk of reperfusion hyperkalemia, and finally because of significantly lower cost and easier handling [11,12]. Recent clinical studies, however, reported conflicting data on the efficacy of HTK and UW after solid organ transplantation [13][14][15][16][17][18][19]. While some studies suggested that UW and HTK have a similar efficacy [17,18], others observed a lower incidence of delayed graft function and an improved graft survival when UW was used [14][15][16]19].…”

Section: Introductionmentioning

confidence: 99%

UW is Superior Compared with HTK After Prolonged Preservation of Renal Grafts

Hoeger

Lueg

Tsagogiorgas

et al. 2011

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 99%

UW is Superior Compared with HTK After Prolonged Preservation of Renal Grafts

Hoeger

Lueg

Tsagogiorgas

et al. 2011

Journal of Surgical Research

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“…The combination of two osmotically active components enables successful transplantation outcome and better physiological function and less histological damage of kidney than Euro-Collins [45]. In case of marginal donor organs, UW solution-preserved organs showed a lower rate of primary non-function and rejection rate during the first 12 months after transplantation [46].…”

Section: University Of Wisconsin Solutionmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

287

233

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Organ transplantation has developed over the past 50 years to reach the sophisticated and integrated clinical service of today through several advances in science. One of the most important of these has been the ability to apply organ preservation protocols to deliver donor organs of high quality, via a network of organ exchange to match the most suitable recipient patient to the best available organ, capable of rapid resumption of life-sustaining function in the recipient patient. This has only been possible by amassing a good understanding of the potential effects of hypoxic injury on donated organs, and how to prevent these by applying organ preservation. This review sets out the history of organ preservation, how applications of hypothermia have become central to the process, and what the current status is for the range of solid organs commonly transplanted. The science of organ preservation is constantly being updated with new knowledge and ideas, and the review also discusses what innovations are coming close to clinical reality to meet the growing demands for high quality organs in transplantation over the next few years.

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“…Acute rejection and surgical complications are the most common causes of PNF [19]. The use of histidine-tryptophanketoglutarate (HTK) solution has also been implicated as a cause of PNF in deceased donor renal transplants [17]. A recent study suggests that a mean arterial blood pressure less than or equal to 80 mm Hg approximately 3 months before kidney transplantation is a risk factor for PNF [18].…”

Section: Primary Non-functionmentioning

confidence: 99%

“…Primary non-function (PNF), defined as the lack of adequate allograft function by the third month post transplant, has a reported incidence between 1-8% [17][18][19]. Typically, patients at risk of PNF include highly sensitized patients and those on renal replacement therapy for a prolonged duration of time prior to transplantation.…”

Section: Primary Non-functionmentioning

confidence: 99%