Increased pro-inflammatory cytokine production in vitamin B12 deficient adipocytes

Samavat, Jinous; Adaikalakoteswari, Antonysunil; Boachie, Joseph; Saravanan, Ponnusamy

doi:10.1530/endoabs.59.p158

Cited by 8 publications

(6 citation statements)

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“…reported that vitamin B12 regulated IL‐6 levels in rat cerebrospinal fluid, independently of other regulators of IL‐6 production such as vasoactive intestinal peptide or somatostatin. An in vitro study found increased gene expression of IL‐6 and other interleukins in adipocytes cultured in low vitamin B12 conditions 38 . These results are in line with the findings of the present study because we have observed that higher levels of vitamin B12 relate to lower concentrations of IL‐6 in mice.…”

Section: Discussionsupporting

confidence: 92%

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

Domínguez‐López,

Kovatcheva,

Casas

et al. 2023

J Sci Food Agric

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BackgroundVitamin B12 is an essential nutrient that is involved in numerous physiological processes, and its deficiency can lead to various complications, including neurological and haematological disorders. Some studies have suggested that vitamin B12 may have anti‐inflammatory effects, but the mechanisms underlying this relationship are not yet fully understood. We investigated the relationship between circulating vitamin B12 and inflammatory markers interleukin‐6 (IL‐6) and C‐reactive protein (CRP). The association of peripheral levels of vitamin B12 with IL‐6 and CRP was assessed in 136 human samples from a high cardiovascular risk population. To corroborate the results from the human trial, the analysis was replicated in naturally aged mice.ResultsIndividuals with higher serum levels of vitamin B12 showed lower concentrations of IL‐6 and CRP after adjustment for potential confounders, and an inverse association was also found between serum IL‐6 and vitamin B12 levels in naturally aged mice.ConclusionsThat circulating vitamin B12 was inversely associated with IL‐6 and CRP in humans and with IL‐6 in mice suggests that it may exert an anti‐inflammatory effect through modulation of these pro‐inflammatory molecules.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 92%

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

Domínguez‐López,

Kovatcheva,

Casas

et al. 2023

J Sci Food Agric

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“…Al-Daghri et al [ 35 ] measured systemic Vit B 12 concentrations with pro-inflammatory cytokines and concluded that serum Vit B 12 concentrations were associated with pro-inflammatory cytokines. In their in vitro study, Jinous et al [ 36 ] found that low adipocyte Vit B 12 levels induced greater gene expression and secretion of pro-inflammatory cytokines. Their results suggest that this change results in adipocyte dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

Kim

Yoon

et al. 2021

BMC Musculoskelet Disord

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Background Vitamin B12 (Vit B12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B12 levels were correlated with degenerative rotator cuff (RC) tear. Methods Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear. Results In the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4 pg/mL Vit B12, which was significantly lower than the healthy control group (627.1 pg/mL). Logistic regression analysis using Vit B12 as an independent variable revealed that Vit B12 concentrations were significantly correlated with degenerative RC tear (p = 0.044). However, Vit B12 levels were not associated with tear size. Conclusion Low serum levels of Vit B12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B12 supplementation can decrease the risk of this condition.

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“…Both study groups achieved significant reductions in BMI, however the unparallel link between IL-6 and BMI in the LCVD raises questions for recent conclusions devised by Jaceldo-Siegl et al (2018) , whereby lower IL-6 concentrations among vegetarians remained associated with BMI amongst overweight adult participants. Therefore, it may be concluded that a longer intervention is required to assess the association between a LCVD diet and IL-6, or findings could instead add to those from Samavat et al (2018) whereby low vitamin B 12 conditions, commonly presented in the presence of vegetarian diets, have aligned significantly with increased expression of pro-inflammatory cytokines such as interleukin-6 (IL-6) ( Sofi et al, 2018 ). Although not significant, Stendell-Hollis et al (2013) reported reductions in IL-6 amongst those who consumed the MD and MP diet at 4-months follow up.…”

Section: Discussionmentioning

confidence: 99%

The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review

2022

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Background COVID-19 severity is strongly associated with high Body Mass Index (BMI) (≥25kg/m2) amongst adults and elevated inflammatory markers have enabled prediction of disease progression. The composition of a Mediterranean diet provides favourable outcomes on weight reduction and inflammatory markers. Aim This systematic review aimed to investigate the effects of consuming a Mediterranean diet on BMI and inflammatory markers of obese/overweight adults (≥18 years) at risk of developing severe COVID-19 outcomes. Methods PubMed Central, Cochrane Library and MEDLINE databases were searched to identify randomised controlled trials published between January 2010 to August 2021 evaluating the impact of Mediterranean diet on BMI and inflammatory markers in overweight/obese adults. The review followed the PRISMA checklist, used Cochrane Collaboration search strategies, and is PROSPERO registered (CRD42021277070). Two authors independently screened and evaluated studies for methodological quality. Papers were extracted and included based eligibility, despite risk of bias scores. Results Of 65 extracted records, six studies met the eligibility criteria and were included. Reductions in BMI, TNF-α, IL-6 and hs-CRP were reported amongst most findings, the majority of which were significant. Conclusion The main findings indicate a hypocaloric, fibre dense Mediterranean diet is a short-term (<4 months) mitigation strategy to significantly reduce BMI and inflammatory markers amongst overweight/obese adults at risk of developing severe COVID-19 outcomes. Further research is now needed to examine the role of Mediterranean diet in COVID-19 prevalence, severity, morbidity and mortality.

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Increased pro-inflammatory cytokine production in vitamin B12 deficient adipocytes

Cited by 8 publications

References 0 publications

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review

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