Increased proliferation of phytohaemagglutinin (PHA)-stimulated human leucocytes after 8-methoxypsoralen treatment

Gawron, Antoni; Gorski, Grzegorz; Głowniak, Kazimierz

doi:10.1111/j.2042-7158.1990.tb05384.x

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-Mop In Therapeutic Concentrations Does Not Effect Lympho-1

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1991

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“…Our earlier studies have shown that 8-MOP (1 pg mL-') (i.e. at clinical values reached in the blood of treated subjects) can stimulate PHA-transformed leucocytes (Gawron et al 1990). In the present studies it was found that 8-MOP ( I pg mL-') enhanced the mitogenic effect of PHA on lymphocytes by acting on T-lymphocytes.…”

Section: -Mop In Therapeutic Concentrations Does Not Effect Lympho-supporting

confidence: 55%

Effect of 8-methoxypsoralen in the dark on proliferation of stimulated lymphocytes

Gorski

Antosz

Gawron

1991

Journal of Pharmacy and Pharmacology

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The effect of 8-methoxypsoralen (8-MOP) in the dark on proliferation of phytohaemagglutinin-stimulated human lymphocytes has been examined, using total blood leucocytes, the lymphocyte fraction and the T-lymphocyte subpopulation. 8-MOP (1 microgram mL-1) increased [3H]TdR incorporation and caused a rise in the blastic and mitotic index in all experimental cultures. The lymphocyte proliferation in these experiments was effected by a comitogenic effect of 8-MOP on T-lymphocytes.

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Section: -Mop In Therapeutic Concentrations Does Not Effect Lympho-supporting

confidence: 55%