2010
DOI: 10.1016/j.tiv.2009.10.017
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Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells

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Cited by 25 publications
(5 citation statements)
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“…In particular, psoralen, 5-methoxypsoralen (5-MOP), and 8-methoxypsoralen (8-MOP) are well known for their phototoxic, photomutagenic, and photocarcinogenic properties [54,55]. Recently, it has been shown that bergamottin does not exert any significant photomutagenicity on its own, as tested by a model of photomutagenicity of some furanocoumarins in V79 cells using 5-MOP as a reference compound [56]. Interestingly, the potential protective effects of furanocoumarins have also been studied in various cancer models.…”
Section: Bergamottin and Cancermentioning
confidence: 99%
“…In particular, psoralen, 5-methoxypsoralen (5-MOP), and 8-methoxypsoralen (8-MOP) are well known for their phototoxic, photomutagenic, and photocarcinogenic properties [54,55]. Recently, it has been shown that bergamottin does not exert any significant photomutagenicity on its own, as tested by a model of photomutagenicity of some furanocoumarins in V79 cells using 5-MOP as a reference compound [56]. Interestingly, the potential protective effects of furanocoumarins have also been studied in various cancer models.…”
Section: Bergamottin and Cancermentioning
confidence: 99%
“…There are furocoumarins that are uniquely abundant in the peels of citrus fruit, which are not typically consumed; however, they can migrate into the juice during the juicing process, giving juice a different furocoumarin profile [ 35 ]. Some of these furocoumarins have different carcinogenic potentials, therefore, possibly explaining the differences in cytotoxicity with respect to NMSC pathophysiology [ 37 , 38 ]. However, as the indexing of the carcinogenicity of the numerous furocoumarin compounds is still in its nascent stages, future investigations are needed for confirmation.…”
Section: Discussionmentioning
confidence: 99%
“…But, using 5-MOP and 8-MOP as a model for the risk assessment of plants which FCs are rich in might make the assessment inaccurate. Fortunately, recent researchers have proposed the concept of the toxic equivalency factor (TEF) based on photomutagenic, photocytotoxic, and photoclastogenic properties in a V79 cells experiment, which suggested that the photogenotoxic and phototoxic properties of individual furocoumarins may diverge widely but showed relatively strict additivity once occurring as multifarious mixtures [27,28]. Moreover, in 2008, the European Food Safety Authority (EFSA) conducted a series of research in experimental animals, declared that the carcinogenic influence was not triggered via a genotoxic mechanism, and then proposed the tolerable daily intake (TDI) values (0.1 mg coumarin/kg bw/day) based on the non-observed adverse effect level (NOAEL) for liver toxicity in a 2-year dog study [29].…”
Section: Introductionmentioning
confidence: 99%