Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy

Ko, Jeong‐Hyeon; Arfuso, Frank; Sethi, Gautam; Ahn, Kwang Seok

doi:10.3390/ijms19124048

Cited by 41 publications

(29 citation statements)

References 98 publications

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“…Angelicin inhibits A549 non-small-cell lung carcinoma (NSCLC) growth and metastasis by reducing MMP-2,9; increasing E-cadherin expression levels and JNK, and ERK activation [33]. Bergamottin inhibited the migration abilities of A549, H1299 [34]; HT-1080 cells [35] and human fibrosarcoma HT-1080 cells [36], by decreasing the phorbol 12-myristate 13-acetate (PMA)-initiated enactment of matrix metallo proteinase (MMP)-2,9; c-jun N-terminal kinase (JNK) phosphorylation and EMT inhibition through NF-κB inactivation. Psoralen give similar response in MCF-7/ADR cells [37].…”

Section: Nf-κb Inactivationmentioning

confidence: 99%

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Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

134

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Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.

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Section: Nf-κb Inactivationmentioning

confidence: 99%

“…Imperatorin reduced IL-6, -1β, and TNF-α discharge and inhibited iNOS and COX-2 by repressing NF-κB in RAW 264.7 (murine-macrophages-cell lines) [45,46]. Bergamottin, Bergapten and Psoralen inhibit ROS/NO generation for anti-inflammatory activity [35,47,48].…”

Section: Nf-κb Inactivationmentioning

confidence: 99%

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

134

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“…Large scale production, low cost and the aroma characteristic remaining are the big advantages of the cold-pressing method. However, cold-pressed grapefruit oil contains waxes, pesticide residues, coumarins, carotenoids and other nonvolatile components [28][29][30], some of them also have good bioactivities that may cause bias in bioactivity research of EO. César et al (2009) found that furanocoumarins isolated from grapefruit peel oil showed potent in vitro inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in "grapefruit/drug" interactions in humans [28].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

et al. 2020

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Grapefruit essential oil has been proven to have wide range of bioactivities. However, bioactivity of its molecular distillate has not been well studied. In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify its chemical composition. The antimicrobial activity of the light phase oil was tested by filter paper diffusion method, and the anticancer activity was determined by the Cell Counting Kit-8 (CCK-8) assay. Twenty-four components were detected with a total relative content of 99.74%, including 97.48% of terpenes and 1.66% of oxygenated terpenes. The light phase oil had the best antimicrobial effect on Bacillus subtilis, followed by Escherichia coli, Staphylococcus aureus and Salmonellaty phimurium. DPPH and ABTS assays demonstrated that the light phase oil had good antioxidant activity. The CCK-8 assay of cell proliferation showed that the light phase oil had a good inhibitory effect on the proliferation of HepG2 liver cancer cells and HCT116 colon cancer cells.

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“…It is estimated that metastases, i.e. cancer cells that spread from their site of origin to distant organs and initiate the formation of secondary tumors, are responsible for around 90% of mortality in cancer patients 1 . Hence, metastasis is both a critical measure of cancer severity and an important target for cancer therapy.…”

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confidence: 99%

CAM-Delam: an in vivo approach to visualize and quantify the delamination and invasion capacity of human cancer cells

Palaniappan

Šlekienė

Jonasson

et al. 2020

Sci Rep

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the development of metastases is the major cause of cancer related death. to develop a standardized method that define the ability of human cancer cells to degrade the basement membrane, e.g. the delamination capacity, is of importance to assess metastatic aggressiveness. We now present the in vivo CAM-Delam assay to visualize and quantify the ability of human cancer cells to delaminate and invade. The method includes seeding cancer cells on the chick chorioallantoic membrane (CAM), followed by the evaluation of cancer-induced delamination and potential invasion within hours to a few days. By testing a range of human cancer cell lines in the cAM-Delam assay, our results show that the delamination capacity can be divided into four categories and used to quantify metastatic aggressiveness. our results emphasize the usefulness of this assay for quantifying delamination capacity as a measurement of metastatic aggressiveness, and in unraveling the molecular mechanisms that regulate delamination, invasion, formation of micro-metastases and modulations of the tumor microenvironment. This method will be useful in both the preclinical and clinical characterization of tumor biopsies, and in the validation of compounds that may improve survival in metastatic cancer.

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Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy

Cited by 41 publications

References 98 publications

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

CAM-Delam: an in vivo approach to visualize and quantify the delamination and invasion capacity of human cancer cells

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