Increased psychological distress among individuals with spinal cord injury is associated with central neuropathic pain rather than the injury characteristics

Gruener, Hila; Zeilig, Gabi; Laufer, Yocheved; Blumen, Nava; Defrin, Ruth

doi:10.1038/s41393-017-0014-6

Cited by 22 publications

(17 citation statements)

References 62 publications

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“…Various sensory disorders, including chronic pain, central neuropathic pain and sensory paraesthesia, affect the patients’ life quality every second 5,31 . Central neuropathic pain especially tortures the patient due to the lack of an efficient treatment strategy, and the depression associated with central neuropathic pain could lead to suicide 5,32 . Thus, focusing on sensory neuron neurite regeneration to recover sensory function post‐spinal cord injury is particularly important.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, sensory disorders are difficult to handle in the clinic due to limited effective treatment strategies. Central neuropathic pain induced by SCI is insensitive to pharmacological, surgical, physical, and behavioural treatments 5 . Thus, developing efficient treatment strategies to promote the recovery of sensory function is of particular importance to SCI patients.…”

Section: Introductionmentioning

confidence: 99%

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miR‐30b Promotes spinal cord sensory function recovery via the Sema3A/NRP‐1/PlexinA1/RhoA/ROCK Pathway

Wang

et al. 2020

J Cellular Molecular Medi

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR‐30b Promotes spinal cord sensory function recovery via the Sema3A/NRP‐1/PlexinA1/RhoA/ROCK Pathway

Wang

et al. 2020

J Cellular Molecular Medi

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“…For instance, the induction of insulin resistance or experimental diabetes in rodents through exposure to high-fat diet leads to symptoms of depression including anxiety, despair and anhedonia ( Gariepy et al., 2010 ; Ho et al., 2012 ; André et al., 2014 ). Several studies also suggest that neuropathic pain is associated with stress, anxiety and depression ( Yalcin et al., 2011 ; Descalzi et al., 2017 ; Hestehave et al., 2019 ; Humo et al., 2019 ; Murasawa et al., 2020 ) whereas that chronic stress exacerbates chronic pain ( Narita et al., 2006 ; Li et al., 2017 ; Gruener et al., 2018 ; Sieberg et al., 2018 ). These comorbidities have considerably increased contributing to disability, sleep disturbances, poor quality of life and healthcare costs.…”

Section: Effects Of Metformin On Painmentioning

confidence: 99%

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

et al. 2020

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Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent. The search for the mechanism of action of metformin has produced an enormous amount of research to explain its effects on gluconeogenesis, protein metabolism, fatty acid oxidation, oxidative stress, glucose uptake, autophagy and pain, among others. It was only up the end of the 1990s and beginning of this century that some of its mechanisms were revealed. Metformin induces its beneficial effects in diabetes through the activation of a master switch kinase named AMP-activated protein kinase (AMPK). Two upstream kinases account for the physiological activation of AMPK: liver kinase B1 and calcium/ calmodulin-dependent protein kinase kinase 2. Once activated, AMPK inhibits the mechanistic target of rapamycin complex 1 (mTORC1), which in turn avoids the phosphorylation of p70 ribosomal protein S6 kinase 1 and phosphatidylinositol 3kinase/protein kinase B signaling pathways and reduces cap-dependent translation initiation. Since metformin is a disease-modifying drug in type 2 diabetes, which reduces the mTORC1 signaling to induce its effects on neuronal plasticity, it was proposed that these mechanisms could also explain the antinociceptive effect of this drug in several models of chronic pain. These studies have highlighted the efficacy of this drug in chronic pain, such as that from neuropathy, insulin resistance, diabetic neuropathy, and fibromyalgia-type pain. Mounting evidence indicates that chronic pain may induce anxiety, depression and cognitive impairment in rodents and humans. Interestingly, metformin is able to reverse some of these consequences of pathological pain in rodents. The purpose of this review was to analyze the current evidence about the effects of metformin in chronic pain and three of its comorbidities (anxiety, depression and cognitive impairment).

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“…Patients with SCI often develop chronic neuropathic pain, which is considered as the most debilitating pain determined by the clinical neurological examination based on its definition and characteristics (Widerström-Noga et al, 2008). These include spontaneous and/or evoked burning, stabbing or shooting pain located in diffuse body regions (Gruener, Zeilig, Laufer, Blumen, & Defrin, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement ofERKandAKTsignalling pathway

Fakhri

Dargahi

Abbaszadeh

et al. 2018

European Journal of Pain

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Background Spinal cord injury (SCI) causes continuous neurological deficits and major sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor function following SCI. Thus, it is crucial to develop novel therapeutics for this particular patient population. Astaxanthin (AST) is a strong antioxidant, anti‐inflammatory and anti‐apoptotic agent. In the present study, it was tested in a severe compression SCI model with emphasis on sensory‐motor outcomes, signalling pathway, along with other complications. Methods A severe SCI was induced by compression of the rat thoracic spinal cord with an aneurysm clip and treatment with AST or the vehicle was carried out, 30 min after injury. Behavioural tests including open field, von Frey, hot plate and BBB were performed weekly to 28 days post‐injury. Rats were assigned to measure blood glucose, weight and auricle temperature. Western blot and histological analysis also were performed at the same time points. Results AST decreased mechanical and thermal pain and also improved motor function performance, reduced blood glucose and auricle temperature increases and attenuated weight loss in SCI rats. Western blot analysis showed decreased activation of ERK1/2 and increased activation of AKT following AST treatment. The histology results revealed that AST considerably preserved myelinated white matter and the number of motor neurons following SCI. Conclusion Taken together, the beneficial effects of AST to improve sensory‐motor outcomes, attenuate pathological tissue damage and modulate ERK and AKT signalling pathways following SCI, suggest it as a strong therapeutic agent towards clinical applications. Significance Spinal cord injury (SCI) impairs sensory‐motor function and causes complications, which astaxanthin (AST) has the potential to be used as a treatment for. The present study investigates the effects of AST in a compression model of SCI with emphasis on sensory‐motor outcomes alongside other complications, histopathological damage and also related signalling pathways.

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Increased psychological distress among individuals with spinal cord injury is associated with central neuropathic pain rather than the injury characteristics

Cited by 22 publications

References 62 publications

miR‐30b Promotes spinal cord sensory function recovery via the Sema3A/NRP‐1/PlexinA1/RhoA/ROCK Pathway

miR‐30b Promotes spinal cord sensory function recovery via the Sema3A/NRP‐1/PlexinA1/RhoA/ROCK Pathway

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement ofERKandAKTsignalling pathway

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