Increased pulmonary and intestinal permeability in Crohn's disease.

Adenis, Antoine; Colombel, Jean–Frédéric; Lecouffe, P.; Wallaert, B.; Hecquet, B; Marchandise, X.; Cortot, Antoine

doi:10.1136/gut.33.5.678

Cited by 70 publications

(46 citation statements)

References 35 publications

(1 reference statement)

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“…An increased frequency of asymptomatic bronchial hyperresponsiveness has been reported in patients with Crohn's disease, and a subclinical accumulation of activated T lymphocytes has been demonstrated in the lung of patients with Crohn's disease without respiratory symptoms (19,25). No study has demonstrated thus far the simultaneous presence of alveolar lymphocytosis and bronchial hyperresponsiveness to methacholine in respiratory asymptomatic patients with Crohn's disease.…”

Section: Introductionmentioning

confidence: 99%

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Bártholo

Zaltman

Elia

et al. 2005

Braz J Med Biol Res

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With the aim of investigating the presence of latent inflammatory process in the lungs of patients with Crohn's disease, 15 patients with Crohn's disease were evaluated by spirometry, the methacholine challenge test, induced sputum, and skin tests for inhaled antigens. Serum IgE, erythrocyte sedimentation rate and hematocrit were also determined. The patients were compared with 20 healthy controls by the Mann-Whitney and Fisher exact tests. Their respiratory physical examination was normal. None had a personal or family history of clinical atopy. None had a previous history of pulmonary disease, smoking or toxic bronchopulmonary exposure. None had sinusitis, migraine, diabetes mellitus, or cardiac failure. Four (26.6%) of the patients with Crohn's disease had a positive methacholine challenge test whereas none of the 20 controls had a positive methacholine test (P = 0.026, Fisher exact test). Patients with Crohn's disease had a higher level of lymphocytes in induced sputum than controls (mean 14.59%, range 3.2-50 vs 5.46%, 0-26.92%, respectively; P = 0.011, Mann-Whitney test). Patients with Crohn's disease and a positive methacholine challenge test had an even higher percentage of lymphocytes in induced sputum compared with patients with Crohn's disease and a negative methacholine test (mean 24.88%, range 12.87-50 vs 10.48%, 3.2-21.69%; P = 0.047, Mann-Whitney test). The simultaneous findings of bronchopulmonary lymphocytosis and bronchial hyperresponsiveness in patients with Crohn's disease were not reported up to now. These results suggest that patients with Crohn's disease present a subclinical inflammatory process despite the absence of pulmonary symptoms.

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Section: Introductionmentioning

confidence: 99%

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Bártholo

Zaltman

Elia

et al. 2005

Braz J Med Biol Res

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“…IP has been implicated in the pathogenesis and frequent relapses of Crohn's disease (CD) [2][3][4][5][6] . Seven to 18% higher relapse rate has been reported in patients with increased IP compared to those with normal IP [7][8][9][10][11] .…”

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confidence: 99%

“…A number of studies have reported a relationship between abnormal IP and the activity of the disease [3,5,37,38] . In some reports it has been observed that the magnitude of alterations in L/M ratio increases with the increase in disease activity index.…”

mentioning

confidence: 99%

Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Benjamin¹,

Makharia²,

Ahuja³

et al. 2008

WJG

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INTRODUCTIONIntestinal permeability (IP) is the property of the intestinal epithelium which refers to the facility with which it allows molecules to pass through by non-mediated diffusion [1] . IP has been implicated in the pathogenesis and frequent relapses of Crohn's disease (CD) [2][3][4][5][6] . Seven to 18% higher relapse rate has been reported in patients with increased IP compared to those with normal IP [7][8][9][10][11] . Moreover, RAPID COMMUNICATIONIntestinal permeability and its association with the patient and disease characteristics in Crohn's disease Abstract AIM: To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics.

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“…The increased rate of DTPA clearance indicates inflammation or lung insults of any cause. In two of three published papers, a significantly higher alveolar epithelial permeability was reported in IBD patients compared to healthy people [40,41]. In the third study, no evidence of abnormal lung permeability in patients with IBD was found [42].…”

Section: Epidemiologymentioning

confidence: 89%

“…Bronchial hyperresponsiveness on methacholine challenge was independent of activity, extent and time of duration of IBD [29][30][31]. Exhaled NO correlated positively with IBD activity [37][38][39], but no relation was found for alveolar epithelial per-meability measured with the use of Tc-99m DTPA aerosol scintigraphy [40,41]. Data on relationship between IBD activity and chest HRCT picture are discrepant.…”

Section: Respiratory Disease Depending On Ibd Activitymentioning

confidence: 99%