Increased Pulmonary Megakaryocytes-Probable Role in Postoperative Thromboembolism

Sharnoff, J. G.

doi:10.1001/jama.1959.03000240026006

Cited by 37 publications

(3 citation statements)

References 4 publications

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“…Return of platelet count to normal generally occurs in the third week. The influence of stress has been suggested in the mechanism of the above changes (Williams et al 1956, Sharnoff 1959, Pepper and Lindsay 1960. The most satisfactory explanation for postoperative thrombocytopenia is perhaps that a massive platelet consumption is required for initiation of hemostasis (Umbach et al 1959).…”

Section: Discussionmentioning

confidence: 99%

Changes in Platelet Aggregability after Ovariectomy

et al. 1979

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SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

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Section: Discussionmentioning

confidence: 99%

Changes in Platelet Aggregability after Ovariectomy

et al. 1979

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“…L'on salt, qu'au cours des suites op~ratoires, il survient une augmentation de la viscosit6 et du nombre des plaquettes et une plus grande activi% du fibrinog~ne et de la protht'ombine. On a .152 CANADIAN ANAEST~IETISTS' SOCIETY JOURNAL 6mis 1'opinion (19) que cela 6tait une r6ponse ~ l'agression que causaient l'anesth6sie et la chirurgie.…”

Section: Discussionunclassified

Anaesthesia and pulmonary embolism

Jenkins

Graves

1961

Can. Anaes. Soc. J.

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“…Recent years have witnessed an increasing interest in the study of the possible relationship of blood coagulation to intravascular thrombosis (1)(2)(3)(4). In spite of numerous methods of investigation, a consistent means of demonstrating and defining a clotting abnormality in thromboembolic diseases has not emerged.…”

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confidence: 99%