Increased pulmonary residual volume in patients with hyperlipoproteinemias

Conti, Franco; Amaducci, S; Sirtori, Cesare R.

doi:10.1016/0021-9150(77)90038-7

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…Bagade and Ways [1970] proposed that altered lipid components existed in the ery throcyte membrane which interfere with ox ygen transfer across the erythrocyte wall. An increase in residual volume with normal airway flow resistances in hyperlipidémie subjects was found by Conti et al [1977], who attributed this to a situation of pulmo nary hyperdistension. Enz.i et al [1976] pro posed a modification of the alveolar surfac tant with consequent disturbances in pul monary compliance and alveolar ventila tion, which in turn affected respiratory gas exchange.…”

Section: Disciissionmentioning

confidence: 99%

Alveolo-Arterial Gradients of O2 and CO2 in Hyperlipidemic Subjects

Cavallo‐Perin¹,

Cardellino²,

Garbagni³

1982

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In 20 hypertriglyceridemic normocholesterolemic patients, mean age 51 years (range 42–62), ± 10% ideal body weight, and in 18 normolipidemic controls, mean age 49 years (range 41–63), ± 10% ideal body weight, the following tests were performed: spirometry, flow-volume curves, arterial blood gases, alveolo-capillary transfer of CO, alveolo-arterial gradients of O₂ and arterio-alveolar gradients of CO₂. A significant decrease in the arterial partial pressure of O₂ and in the transfer of CO, with a significant increase in the alveolo-arterial gradient of O₂ were found. Hypertriglyceridemia seems to compromise the alveolo-capillary gas exchange.

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Section: Disciissionmentioning

confidence: 99%

Alveolo-Arterial Gradients of O2 and CO2 in Hyperlipidemic Subjects

Cavallo‐Perin¹,

Cardellino²,

Garbagni³

1982

Respiration

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“…Furthermore, abnormalities of the respiratory function, such as reduced arte rial oxygen tension and CO diffusion ca pacity, altered ventilation/diffusion ratio distribution [5], increased residual volume and closing capacity [6], have been re ported in patients affected with hyper lipidemia of Frederickson's types I, 11, IV and V.…”

mentioning

confidence: 99%

Mechanical Behavior of Isolated Lungs in Hyperlipemic Animals

Allegra¹

1985

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Altered pulmonary function has been reported by many authors in hyperlipemic animals and patients. Our experiments show that isolated lungs of rats rendered hyperlipemic by means of suitable diets display a significantly increased static compliance when pressure-volume (P-V) curves are analyzed during deflation following inflation with air. No differences are observed when P-V curves are obtained with saline. Furthermore the stability index calculated through the analysis of the deflation curve was significantly higher in rats treated with two different hyperlipidic diets (average stability index: 1.06 and 1.04 in the two treated groups, both significantly higher than the two control groups, 0.80 and 0.72, p < O.Ol in both cases). The observed mechanical effects of hyperlipidemia on lung characteristics in rats show that altered surfactant properties and function play a major role in these experimental conditions.

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