Increased release of immunoreactive calcitonin gene-related peptide (CGRP) in tears after excimer laser keratectomy

Mertaniemi, Päivi; Ylätupa, Sari; Partanen, Pirjo; Tervo, Timo

doi:10.1016/s0014-4835(05)80007-7

Cited by 42 publications

(29 citation statements)

References 36 publications

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“…Corneal nerves also play an important trophic role in epithelial cell growth, wound healing, and repair through the release of specific neuropeptides and neurotransmitters. [1][2][3][4] The subbasal nerve plexus (SBNP) is a nerve fiber layer that is located beneath the corneal epithelium and detected relatively easily using in vivo laser-scanning confocal microscopy. Consequently, it is a common subject for evaluation when investigating the impact of ocular and systemic diseases on corneal innervation, such as in dry eye, 5 infectious keratitis, 6 and keratoconus.…”

Section: Introductionmentioning

confidence: 99%

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Lum¹,

Golebiowski²,

Swarbrick³

2017

The Ocular Surface

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Section: Introductionmentioning

confidence: 99%

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Lum¹,

Golebiowski²,

Swarbrick³

2017

The Ocular Surface

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“…CGRP seems to cause most, if not all, of the ocular changes after sensory nerve stimulation elicited by topical formaldehyde (13). The concentration of CGRP in tears is known to increase with corneal wounding in humans following excimer laser keratectomy due to increased release of CGRP from sensory nerve terminals, and it is thought that CGRP may have a role in wound healing (16).…”

Section: Introductionmentioning

confidence: 99%

CGRP Increases the Rate of Corneal Re-Epithelialization in an In Vitro Whole Mount Preparation

Mikulec¹,

Tanelian²

1996

Journal of Ocular Pharmacology and Therapeutics

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A number of studies have localized CGRP to nerves in the cornea and iris, and it is thought that CGRP, along with other neuropeptides, is involved in pain sensation. It is also possible that CGRP could mediate trophic influences between nerve endings and corneal epithelium. This investigation utilized an in vitro rabbit corneal whole mount preparation to study the effect of topical 2.5 microM CGRP application on epithelial wound healing rates of 5 mm diameter epithelial wounds. CGRP (2.5 microM) was applied topically to 5 mm epithelial wounds at 0, 4, 16, 20, 24, 28, 40, 44, 48, 52, 56, 64, 68, and 72 hours after wounding and healing was visualized with fluorescein. CGRP was found to increase the epithelial wound healing rate by 25%, from 51 +/- 3 microns/hr for the control corneas, to 64 +/- 2 microns/hr for CGRP-treated corneas (mean +/- standard error, n = 10). Histological examination of the corneas following healing showed that the epithelium of the CGRP-treated corneas healed in a similar manner as in the control corneas. These findings may have clinical utility for the understanding and treatment of corneal and other epithelial wounds.

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“…However, its use is limited as recombinant growth factors are still not cost-efficient. Furthermore, there are several neuropeptides involved in nerve regeneration, such as NGF, substance P, and calcitonin gene-related peptide, which are altered in tear films after refractive surgery, suggesting that they may be key factors in the dry eye after LASIK surgery [27, 28]. …”

Section: Discussionmentioning

confidence: 99%

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery

et al. 2018

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Purpose: The aim of this study was to evaluate the use of plasma rich in growth factors (PRGF) eye drops in patients with dry eye disease after laser-assisted in situ keratomileusis (LASIK) surgery. Material and Methods: This is a longitudinal, retrospective, comparative, and descriptive study of 77 eyes of 42 patients with dry eye disease following LASIK surgery. This study was designed to evaluate the efficacy of PRGF treatment compared to conventional therapy (control group). Outcome measures including signs and symptoms of dry eye disease were evaluated before and after treatment. The percentage of change before and after treatment for each clinical variable measured was compared between both groups. Results: There were 1–4 treatment cycles with PRGF eye drops (1 cycle = 6 weeks). Results showed a statistically significant improvement in the Ocular Surface Disease Index (38.12%), visual analogue scale scores for frequency (41.89%) and severity (42.47%), and the Schirmer test scores (88.98%) after PRGF treatment (p < 0.05). No adverse events were reported after PRGF treatment. Conclusions: These results suggest that PRGF eye drops are effective for the improvement of dry eye symptoms in patients who underwent LASIK surgery in comparison to the conventional therapy. The treatment with PRGF is an alternative for patients who suffer from postoperative dry eye.

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Increased release of immunoreactive calcitonin gene-related peptide (CGRP) in tears after excimer laser keratectomy

Cited by 42 publications

References 36 publications

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

CGRP Increases the Rate of Corneal Re-Epithelialization in an In Vitro Whole Mount Preparation

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery

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