Increased resistance to quinolone in Catalonia, Spain

Mirelis, Beatriz; Miró, Elisenda; Navarro, Ferrán; Ogalla, Carles A.; Bonal, Joaquin; Prats, G

doi:10.1016/0732-8893(93)90009-v

Cited by 17 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This fact is not surprising, considering the high percentage of E. coli resistant to quinolones in the general population. [30][31][32] Unnoticed previous treatment with quinolones (i.e., outpatient treatment of urinary infections) can account for this finding in our patients, but the most important mechanism is probably patient-to-patient spread of resistant E. coli during hospitalization. 30 Interestingly, plasmid-mediated transferable resistance to quinolones has recently been shown in an E. coli strain.…”

Section: Discussionmentioning

confidence: 91%

“…[19][20][21][22][23][24][25][26][27][28] These studies showed changes in the bacteria responsible for the infections, because cirrhotic patients submitted to prophylaxis with norfloxacin were infected almost exclusively by gram-positive cocci and gram-negative bacilli were rarely observed because of the apparent absence of resistance to quinolones by these bacteria. [19][20][21][22][23][24]29 However, recent studies have shown an increasing incidence in the resistance of gram-negative bacilli to quinolones in the general population, [30][31][32] as well as in neutropenic [33][34] and cirrhotic 23,35,36 patients submitted to prophylaxis with these antibiotics. This is thought to be a result of the current widespread use of quinolones in these populations.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Infections Caused By Escherichia Coli Resistant to Norfloxacin in Hospitalized Cirrhotic Patients

Ortiz¹,

Vila²,

Soriano³

et al. 1999

Hepatology

Self Cite

112

View full text Add to dashboard Cite

Selective intestinal decontamination with norfloxacin is useful to prevent bacterial infections in several groups of cirrhotic patients at high risk of infection. However, the emergence of infections caused by Escherichia coli resistant to quinolones has recently been observed in cirrhotic patients undergoing prophylactic norfloxacin. Our aim is to determine the characteristics of the infections caused by E. coli resistant to norfloxacin in hospitalized cirrhotic patients. One hundred and six infections caused by E. coli in 99 hospitalized cirrhotic patients were analyzed and distributed into two groups: group I (n ‫؍‬ 67), infections caused by E. coli sensitive to norfloxacin, and group II (n ‫؍‬ 39), infections caused by E. coli resistant to norfloxacin. The clinical and analytical characteristics at diagnosis of the infection were similar in both groups. Previous prophylaxis with norfloxacin was more frequent in group II (15/67, 22.4% vs. 32/39, 82%, P F .0001), as a result of a higher number of patients submitted to continuous long-term prophylaxis in this group, whereas previous short-term prophylaxis was similar in both groups. Infections were more frequently nosocomial-acquired in group II than in group I (17/67, 25.3% vs. 20/39, 51.2%, P ‫؍‬ .01). The type of infections was similar in both groups: urinary tract infections 38 in group I and 24 in group II, spontaneous bacterial peritonitis 8 and 2, spontaneous bacteremia 4 and 4, and bacterascites 1 and 0, respectively (pNS). Mortality during hospitalization was similar in the two groups (4/67, 5.9% vs. 5/39, 12.8%, pNS). None of the E. coli resistant to norfloxacin were also resistant to cefotaxime and only one of them was resistant to amoxicillin-clavulanic acid. Prophylaxis with norfloxacin, usually continuous long-term prophylaxis, favors the development of infections caused by norfloxacin-resistant E. coli. Long-term antibiotic prophylaxis should therefore be restricted to highly selected groups of cirrhotic patients at high-risk of infection. Infections caused by E. coli resistant to norfloxacin show a severity similar to those caused by sensitive E. coli. No significant associated resistance between norfloxacin and the antibiotics most frequently used in the treatment of bacterial infections in cirrhotic patients has been observed.

show abstract

Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Infections Caused By Escherichia Coli Resistant to Norfloxacin in Hospitalized Cirrhotic Patients

Ortiz¹,

Vila²,

Soriano³

et al. 1999

Hepatology

Self Cite

112

View full text Add to dashboard Cite

show abstract

“…In Spain, the absence of ciprofloxacin resistance in human strains was reported in 1987; the first three C. jejuni-resistant strains were detected in 1988 (39). Since then a remarkable increase in quinolone resistant strains isolated from humans has been observed for the period 1989 to 1991 (3 to 8% to 19 to 50%, respectively) (25,26,38,43). During that period, this increase in quinolone resistance was also observed in other countries, such as Finland (36), The Netherlands (13), England (5,16,24), and Canada (15).…”

Section: Discussionmentioning

confidence: 96%

Antibiotic Resistance in Campylobacter Strains Isolated from Animals, Foods, and Humans in Spain in 1997–1998

Sáenz

Zarazaga

Lantero

et al. 2000

Antimicrob Agents Chemother

262

172

View full text Add to dashboard Cite

Colonization by Campylobacter strains was investigated in human, broiler, and pig fecal samples from 1997-1998, as well as in foods of animal origin, and antibiotic susceptibility testing was carried out for these strains. Campylobacter strains were isolated in the foods of animal origin (55 of 101 samples; 54.4%), intestinal samples from broilers (85 of 105; 81%), and pigs (40 of 45; 88.9%). A total of 641 Campylobacter strains were isolated from 8,636 human fecal samples of clinical origin (7.4%). Campylobacter jejuni was the most frequently isolated species from broilers (81%) and humans (84%), and Campylobacter coli was most frequently isolated from pigs (100%). An extremely high frequency of ciprofloxacin resistance was detected among Campylobacter strains, particularly those isolated from broilers and pigs (99%), with a slightly lower result for humans (72%); cross-resistance with nalidixic acid was almost always observed. A higher frequency of resistance to erythromycin (81.1%), ampicillin (65.7%), gentamicin (22.2%), and amikacin (21.6%) was detected in C. coli strains isolated from pigs compared to those isolated from humans (34.5, 29.3, 8.6, and 0%, respectively). A low frequency of erythromycin resistance was found in C. jejuni or C. coli isolated from broilers. A greater resistance to ampicillin and gentamicin (47.4 and 11.9%, respectively) was detected in C. jejuni isolated from broilers than in human strains (38 and 0.4%, respectively). ␤-Lactamase production was found in 81% of the Campylobacter strains tested, although 44% of them were characterized as ampicillin susceptible. The increasing rates of Campylobacter resistance make advisable a more conservative policy for the use of antibiotics in farm animals.

show abstract

“…It first gained notoriety during a community-wide outbreak of drug-resistant urinary tract infections in London, England, in 1986England, in -1987. It subsequently was identified among blood isolates in Copenhagen and urine and blood isolates in Spain (15,17,21), where in comparison with other E. coli isolates, it more often infected younger hosts and caused pyelonephritis (21). A recent survey showed it to be broadly distributed across the U.S. and to preferentially infect humans over animals (13).…”

mentioning

confidence: 99%

“…The O15:K52:H1 clonal group of Escherichia coli is a globally distributed extraintestinal pathogen, often associated with multi-antimicrobial drug resistance (7,13,15,17,18,20,21). It first gained notoriety during a community-wide outbreak of drug-resistant urinary tract infections in London, England, in 1986England, in -1987.…”

mentioning

confidence: 99%

Rapid and Specific Detection of the O15:K52:H1 Clonal Group of Escherichia coli by Gene-Specific PCR

et al. 2004

View full text Add to dashboard Cite

show abstract

Increased resistance to quinolone in Catalonia, Spain

Cited by 17 publications

References 7 publications

Infections Caused By Escherichia Coli Resistant to Norfloxacin in Hospitalized Cirrhotic Patients

Infections Caused By Escherichia Coli Resistant to Norfloxacin in Hospitalized Cirrhotic Patients

Antibiotic Resistance in Campylobacter Strains Isolated from Animals, Foods, and Humans in Spain in 1997–1998

Rapid and Specific Detection of the O15:K52:H1 Clonal Group of Escherichia coli by Gene-Specific PCR

Contact Info

Product

Resources

About