Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease

Lin, Sheng‐Hao; Perng, Diahn‐Warng; Chen, Ching-Pei; Chai, Woei-Horng; Yeh, Chin-Shui; Kor, Chew‐Teng; Cheng, Shih-Lung; Chen, Jeremy Jw; Lin, Ching‐Hsiung

doi:10.2147/copd.s115137

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…In another way, isolated case of this sign as a component of obstructive lung disease may increase the frequency of chest infections and associated morbidity similar to COPD and ILD causing the same. [ 11 ] Moreover, the severity of chest infections/pneumonia may also have been increased by the syndrome due to background respiratory distress similar to the present case. Our case is the first documented pneumonia associated with this syndrome, although cirrhosis itself can increase the risk for the same.…”

Section: Discussionsupporting

confidence: 78%

A case of liver cirrhosis and Chilaiditi syndrome with atypical pneumonitis

Krishna

Panda

Hariprasad

et al. 2018

J Family Med Prim Care

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Respiratory distress is very uncommon as a presenting symptom of Chilaiditi syndrome. Furthermore, pneumonia is not documented with the syndrome, compromising further to the distress. We describe a middle-aged man, chronic alcoholic, recently diagnosed with liver cirrhosis, presented with a 1-year history of slowly progressive breathlessness. Recently, he developed mild-to-moderate hemoptysis and cough with aggravation of breathlessness. He did not have fever, chest pain, or orthopnea. He was cyanosed, requiring high-dose oxygen therapy. Later on, he stabilized with noninvasive ventilation. Chest imagings showed incidental Chilaiditi sign, liver cirrhosis, and atypical pneumonitis. With empirical antibiotics and high-dose steroid, he recovered completely but with baseline breathlessness. Here, we outline Chilaiditi syndrome as a rare association or manifestation of liver cirrhosis, and it can present with a respiratory compromise by both obstructive lung disease and atypical interstitial pneumonia. Early identification, vaccinations against common organisms, and possible early surgery may prevent morbidity and mortality of this type of patients.

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Section: Discussionsupporting

confidence: 78%

A case of liver cirrhosis and Chilaiditi syndrome with atypical pneumonitis

Krishna

Panda

Hariprasad

et al. 2018

J Family Med Prim Care

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“…More recent studies evaluated the risk of pneumonia in COPD patients that also have other co-morbid conditions such as cardiovascular disease (CVD). COPD patients with CVD had increased risk of pneumonia 23 . Lin et al 23 reported that COPD patients with CVD who received inhaled corticosteroids (ICS)-containing therapy had significantly increased risk of developing pneumonia compared to those who did not receive ICS-containing therapy or those who only had comorbid CVD.…”

Section: Epidemiologymentioning

confidence: 99%

“…COPD patients with CVD had increased risk of pneumonia 23 . Lin et al 23 reported that COPD patients with CVD who received inhaled corticosteroids (ICS)-containing therapy had significantly increased risk of developing pneumonia compared to those who did not receive ICS-containing therapy or those who only had comorbid CVD. The increased incidence of pneumonia in COPD patients using ICS is discussed latter.…”

Section: Epidemiologymentioning

confidence: 99%

Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

2018

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Chronic obstructive pulmonary disease (COPD) is a frequent comorbid condition associated with increased morbidity and mortality. Pneumonia is the most common infectious disease condition. The purpose of this review is to evaluate the impact of pneumonia in patients with COPD. We will evaluate the epidemiology and factors associated with pneumonia. We are discussing the clinical characteristics of COPD that may favor the development of infections conditions such as pneumonia. Over the last 10 years, there is an increased evidence that COPD patients treated with inhaled corticosteroids are at increased risk to develp pneumonia. We will review the avaialbe information as well as the possible mechanism for this events. We also discuss the impact of influenza and pneumococcal vaccination in the prevention of pneumonia in COPD patients.

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“…Other risk factors also include comorbid cardiovascular diseases, dementia, prior severe AECOPD events, home oxygen, and inhaled corticosteroids. [ 11 – 14 ]…”

Section: Introductionmentioning

confidence: 99%

Independent factors associated with pneumonia among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease

Fang

2018

Medicine

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Acute exacerbations (AE) affect the prognosis of hospitalized patients with chronic obstructive pulmonary disease (COPD). Pneumonia further affects their prognosis and early diagnosis of pneumonia in AECOPD is important to initiate treatments. This study aimed to examine the differences between hospitalized AECOPD patients with and without pneumonia in order to identify risk factors of pneumonia among hospitalized patients with AECOPD.This was a retrospective case–control study of patients with COPD hospitalized at the respiratory ward of Beijing Shijitan Hospital, Capital Medical University, from October 2010 to October 2013. Patients were divided into the pneumonia and nonpneumonia groups based on exudations or opacities on chest computed tomography (CT) at admission. Data were analyzed using the chi-square test and independent 2-sample ANOVA in SPSS 20.0. Logistic regression analysis was used to identify the factors independently associated with pneumonia. P < .05 was considered statistically significant.A total of 164 patients were included. Smoking history (OR = 2.646, 95%CI 1.153–6.074, P = .022), use of drugs during the stable stage (OR = 0.435, 95%CI 0.216–0.877, P = .020), D-dimer levels (OR = 1.001, 95%CI 1.000–1.002, P = .049), percentage of neutrophils (OR = 0.271, 95%CI 0.078–0.940, P = .040), and magnitude of neutrophils increase (OR = 0.946, 95%CI 0.896–0.999, P = .046) were independently associated with pneumonia in patients with AECOPD. For severe and very severe COPD patients, smoking history (OR = 4.426, 95%CI 1.458–13.435, P = .009), use of drugs during the stable stage (OR = 0.384, 95%CI 0.168–0.877, P = .042), and fever (OR = 0.426, 95%CI 0.187–0.969, P = .023) were independently associated with pneumonia.Smoking history, use of drugs during the stable stage, and percentage of neutrophils are independently associated with CT-diagnosed pneumonia among hospitalized AECOPD patients.

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Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease

Cited by 22 publications

References 31 publications

A case of liver cirrhosis and Chilaiditi syndrome with atypical pneumonitis

A case of liver cirrhosis and Chilaiditi syndrome with atypical pneumonitis

Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

Independent factors associated with pneumonia among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease

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