2021
DOI: 10.1007/s10620-021-06895-6
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Increased Risk of Infections with Anti-TNF Agents in Patients with Crohn’s Disease After Elective Surgery: Meta-Analysis

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Cited by 6 publications
(10 citation statements)
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“…Some studies reported a significant increase in overall postoperative complications [ 7 , 8 , 9 , 16 ] or overall infectious postoperative complications [ 3 , 6 , 7 , 9 , 16 ] for anti-TNF-α treated patients, others did not. [ 3 , 5 , 12 , 15 , 17 ]. This meta-analysis found significantly higher overall postoperative complications, readmission rates and intra-abdominal septic complications for anti-TNF-α treated patients ( Figure 2 , Figure 3 and Figure 4 ; Table 3 ; Supplementary Tables S4 and S10 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Some studies reported a significant increase in overall postoperative complications [ 7 , 8 , 9 , 16 ] or overall infectious postoperative complications [ 3 , 6 , 7 , 9 , 16 ] for anti-TNF-α treated patients, others did not. [ 3 , 5 , 12 , 15 , 17 ]. This meta-analysis found significantly higher overall postoperative complications, readmission rates and intra-abdominal septic complications for anti-TNF-α treated patients ( Figure 2 , Figure 3 and Figure 4 ; Table 3 ; Supplementary Tables S4 and S10 ).…”
Section: Discussionmentioning
confidence: 99%
“…using the Newcastle-Ottawa scale (NOS) for cohort studies [ 43 ], a valid and commonly used score applied for observational studies. [ 4 , 5 , 6 , 7 , 9 , 16 , 17 , 43 ] The investigators’ (K.C., S.R.) judgements were conclusively justified ( Supplementary Tables S2.1.–S2.51.…”
Section: Methodsmentioning
confidence: 99%
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“…[ 1 , 2 ] However, long-term usage of anti-TNF agents is associated with complications, such as infection, postoperative wound healing failure, malignancy, and immune-mediated diseases. [ 3 , 4 ] Psoriasis, one of the immune-mediated diseases, can occur in IBD patients with anti-TNF agents, but ironically anti-TNF agents are also effective to control psoriasis.…”
Section: Introductionmentioning
confidence: 99%