Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study

Jess, Tine; Frisch, Mørten; Jørgensen, Kristian Tore; Pedersen, Bo Vest; Nielsen, Nete Munk

doi:10.1136/gutjnl-2011-301095

Cited by 120 publications

(86 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the risk was not explained by the recently suggested association between endometriosis and risk of CD 29. Oral contraceptives were also associated with a modest, but non-significant increase in risk of UC.…”

Section: Discussionmentioning

confidence: 64%

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

Khalili

Higuchi

Ananthakrishnan

et al. 2012

Gut

188

134

View full text Add to dashboard Cite

Background Oral contraceptive use has been associated with risk of Crohn’s disease (CD) and ulcerative colitis (UC). Objective To determine whether this association is confounded or modified by other important lifestyle and reproductive factors. Design A prospective cohort study was carried out of 117 375 US women enrolled since 1976 in the Nurses Health Study I (NHS I) and 115 077 women enrolled since 1989 in the Nurses’ Health Study II (NHS II) with no prior history of UC or CD. These women had provided information every 2 years, on age at menarche, oral contraceptive use, parity, menopause status and other risk factors. Diagnoses of CD and UC were confirmed by review of medical records. Cox proportional hazards models were used to calculate HRs and 95% CIs. Results Among 232 452 women with over 5 030 196 person-years of follow-up, 315 cases of CD and 392 cases of UC were recorded through 2007 in NHS II and 2008 in NHS I. Compared with never users of oral contraceptives, the multivariate-adjusted HRs for CD were 2.82 (95% CI 1.65 to 4.82) among current users and 1.39 (95% CI 1.05 to 1.85) among past users. The association between oral contraceptives and UC differed according to smoking history (pheterogeneity = 0.04). Age at menarche, age at first birth and parity were not associated with risk of UC or CD. Conclusion In two large prospective cohorts of US women, oral contraceptive use was associated with risk of CD. The association between oral contraceptive use and UC was limited to women with a history of smoking.

show abstract

Section: Discussionmentioning

confidence: 64%

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

Khalili

Higuchi

Ananthakrishnan

et al. 2012

Gut

188

134

View full text Add to dashboard Cite

show abstract

“…In fact, immune deficits fulfilling most of the basic criteria for autoimmune disease have been described in endometriosis, including polyclonal B-cell activation, abnormalities in T- and B-cell function, tissue damage, and multi-organ involvement [38,39]. Furthermore, allergies, hypothyroidism, inflammatory bowel disease, and fibromyalgia are among a number of autoimmune conditions known to be associated with endometriosis [40,41]. However; it remains unclear whether these comorbidities may be a cause or an effect of the disease.…”

Section: Introductionmentioning

confidence: 99%

Molecular aspects of development and regulation of endometriosis

Aznaurova

Жуматаев

Roberts

et al. 2014

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Endometriosis is a common and painful condition affecting women of reproductive age. While the underlying pathophysiology is still largely unknown, much advancement has been made in understanding the progression of the disease. In recent years, a great deal of research has focused on non-invasive diagnostic tools, such as biomarkers, as well as identification of potential therapeutic targets. In this article, we will review the etiology and cellular mechanisms associated with endometriosis as well as the current diagnostic tools and therapies. We will then discuss the more recent genomic and proteomic studies and how these data may guide development of novel diagnostics and therapeutics. The current diagnostic tools are invasive and current therapies primarily treat the symptoms of endometriosis. Optimally, the advancement of “-omic” data will facilitate the development of non-invasive diagnostic biomarkers as well as therapeutics that target the pathophysiology of the disease and halt, or even reverse, progression. However, the amount of data generated by these types of studies is vast and bioinformatics analysis, such as we present here, will be critical to identification of appropriate targets for further study.

show abstract

“…Guadagno et al investigated the histological correlation between CD and endometriosis and concluded that in women with known endometriosis histological IBD-like lesions, such as crypt distortion and mucosal surface alteration, should be considered as an epiphenomenon of endometriosis, not as a true IBD [18]. A Danish study demonstrated an increased risk of developing IBD among a large cohort of 37661 women with endometriosis and the risk was higher in women who had endometriosis verified by surgery [19]. The authors speculated that this association may be explained by shared immunological features between endometriosis and IBD or it may reflect a consequence of endometriosis treatment (in particular the oral contraceptives).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Diagnosis of Acute Crohn’s Disease and Endometriosis in a Patient Affects HIV

Casiraghi

Baggi

Lanza

et al. 2018

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

This is the case report of a 45-year-old woman affected by HIV, who was hospitalized for diffuse abdominal pain, constipation, and weight loss present for over one month. A colonoscopy showed the presence of a nontransitable stenosis of the ascending colon. A right hemicolectomy was performed. The histological examination reports CD with outbreaks of endometriosis. CD and the HIV infection may coexist in the same individual and it seems that HIV reduces the relapse rate in IBD patients. CD and intestinal endometriosis can also occur simultaneously. The diagnosis is often only made after surgical resection of the diseased segment. These patients were more likely to have stricturing CD but endometriosis does not seem to impact the natural history of CD.

show abstract

Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study

Abstract: The risk of IBD in women with endometriosis was increased even in the long term, hence suggesting a genuine association between the diseases, which may either reflect common immunological features or an impact of endometriosis treatment with oral contraceptives on risk of IBD.

Cited by 120 publications

References 21 publications

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

Molecular aspects of development and regulation of endometriosis

Simultaneous Diagnosis of Acute Crohn’s Disease and Endometriosis in a Patient Affects HIV

Contact Info

Product

Resources

About