Increased Risk of Preeclampsia with Assisted Reproductive Technologies

Kornfield, Molly S.; Gurley, Susan B.; Vrooman, Lisa A.

doi:10.1007/s11906-023-01250-8

Cited by 2 publications

(1 citation statement)

References 75 publications

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“… 42 The absence of corpus luteum in HRC may result in a lack of important substances produced by the corpus luteum other than estradiol and progesterone, which may trigger PAS. 43 Estradiol and progesterone have been reported to be associated with extravillous trophoblast invasion. Therefore, there is a possibility that abnormal invasion may occur as a result of exogenous administration of these hormones.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

Matsuo,

Kotani,

Tano

et al. 2024

Reprod Medicine & Biology

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PurposeNon‐previa placenta accreta spectrum (PAS) is associated with assisted reproductive technology (ART), particularly frozen embryo transfer during hormone replacement therapy (HRC‐FET). We especially aimed to evaluate the prevalence and risk factors for non‐previa PAS in HRC‐FET pregnancies.MethodsOverall, 279 women who conceived through ART at three ART facilities and delivered at a single center were included in this retrospective study. Data regarding endometrial thickness at embryo transfer, previous histories, and type of embryo transfer—HRC‐FET, frozen embryo transfer during a natural ovulatory cycle (NC‐FET), and fresh embryo transfer (Fresh‐ET)—were collected. Univariable logistic regression analyses were conducted.ResultsThe prevalence of non‐previa PAS was 27/192 (14.1%) in the HRC‐FET group and 0 (0.0%) in both the NC‐FET and Fresh‐ET groups. Significantly high odds ratio [95% confidence interval] of non‐previa PAS was associated with a history of artificial abortion (6.45 [1.98–21.02]), endometrial thickness <8.0 mm (6.11 [1.06–35.12]), resolved low‐lying placenta (5.73 [2.13–15.41]), multiparity (2.90 [1.26–6.69]), polycystic ovarian syndrome (2.62 [1.02–6.71]), and subchorionic hematoma (2.49 [1.03–6.04]).ConclusionsA history of artificial abortion, endometrial thickness <8.0 mm, and resolved low‐lying placenta may help in antenatal detection of a high‐risk population of non‐previa PAS in HRC‐FET pregnancies.

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Section: Discussionmentioning

confidence: 99%

Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

Matsuo,

Kotani,

Tano

et al. 2024

Reprod Medicine & Biology

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The Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia

Strauss,

Phoswa,

Mokgalaboni

2024

Viruses

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Pregnant women living with HIV (PWLWHIV) are at an increased risk of developing obstetrics complications such as pre-eclampsia (PE). Antiretroviral therapy (ART) remains the standard treatment for PWLWHIV and non-pregnant women. However, its use has been associated with adverse liver conditions, particularly hepatotoxicity, often marked by elevated liver enzymes (LEEs) as demonstrated by an increased aspartate transferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) in PWLWHIV on ART. Morever, there is limited evidence about the effect of ART on liver function among PWLWHIV and PE. Therefore, this review examines the pathogenesis of PE and the impact of ART on liver function in PWLWHIV with and without PE. With the evidence gathered in this review, it is still unclear whether liver dysfunctions in PWLWHIV in co-existence with orwithout PE result from HIV infection or ART administration or are exacerbated by the presence of PE. Among those without PE, there was an increase in liver enzymes, a decrease, and no effect in other studies in ART-treated PWLWHIV compared to the control group. Additionally, among those with PE, the impact of ART remains unclear due to contradicting results. The notable trend was that nevirapine was associated with a reduced risk of liver dysfunction among PWLWHIV without PE. Therefore, more studies are needed in this area, especially in HIV endemic regions, to understand the exact cause of liver dysfunction in this population. This knowledge is crucial for improving liver function and PE management among PWLWHIV.

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Increased Risk of Preeclampsia with Assisted Reproductive Technologies

Cited by 2 publications

References 75 publications

Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

The Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia

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