Increased Risk of Type 2 Diabetes From a Family History of Coronary Heart Disease and Type 2 Diabetes

Yeung, Edwina; Pankow, James S.; Astor, Brad C.; Powe, Neil R.; Saudek, Christopher D.; Kao, W. H. Linda

doi:10.2337/dc06-1463

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…If one considers an FH of DM without taking into account parental EOCHD, our data show that the inherited phenotypic traits relate to unfavorable body composition, insulin resistance, reduced BCF, higher LDL‐C, increased hs‐CRP, and more microvascular complications. Overall, a poorer BCF prevails among the cardiometabolic abnormalities observed in offspring of diabetic parents . If, conversely, one considers an FH of EOCHD regardless of parental DM, our data show a higher prevalence of all‐cause and organ‐specific macroangiopathies, which is in line with epidemiological evidence …”

Section: Discussionsupporting

confidence: 88%

“…The common form of type 2 diabetes mellitus (T2DM) has a strong hereditary component, involving genes that foster the decline of β‐cell function (BCF) and genes that adversely affect insulin sensitivity (IS) and promote obesity . In addition to these genotypes, which may destabilize glucose homeostasis, other hereditary factors may increase macrovascular risk in diabetic and non‐diabetic patients .…”

Section: Introductionmentioning

confidence: 99%

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Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Hermans

Ahn

Rousseau

2018

Journal of Diabetes

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Familial histories of DM and EOCHD predispose to increased microvascular and macrovascular risk, respectively, with hyperinsulinemia, lipoprotein(a), and dysfunctional HDLs standing out as mediators of the inherited macrovascular risk. Yet, crossing these FHs did not randomly redistribute vascular risk, because patients with parental T2DM had fewer macrovascular diseases regardless of familial EOCHD. The odds of being left-handed were unexpectedly greater in patients with crossed parental histories.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Hermans

Ahn

Rousseau

2018

Journal of Diabetes

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“…Type 2 diabetes is a complex disorder, and both genetic and environmental factors play an important role in the disease development. Family history of diabetes increases the risk of type 2 diabetes (1)(2)(3)(4)(5)(6) . The more cases of diabetes found in a family, the younger the age of onset of type 2 diabetes (7) .…”

mentioning

confidence: 99%

Synergy of BMI and family history on diabetes: the Humboldt Study

Chen

Rennie

Dosman

2009

Public Health Nutr.

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Objective: To examine the joint effect of family history and BMI on diabetes. Design: Cross-sectional study. Setting: A rural community in Saskatchewan, Canada. Subjects: The analysis was based on data from 2081 adults, 18-79 years of age, who participated in the Humboldt Study conducted in 2003. Doctor-diagnosed diabetes and family history of diabetes of biological parents and siblings were self-reported. Body weight and height were objectively measured. The interaction of family history and BMI on diabetes was assessed on an additive scale. Results: The prevalence of diabetes was 7?9 %, and BMI and history of diabetes were two important predictors. The adjusted prevalence ratios were 1?76 (95 % CI 1?37, 2?27) and 2?59 (95 % CI 2?05, 3?31) for those with a BMI of 25?0-29?9 kg/m 2 and of at least 30 kg/m 2 , respectively, compared with a BMI of less than 25 kg/m 2 , and was 2?41 (95 % CI 2?08, 2?80) for those with a family history of diabetes v. those without. The data indicated an additive interaction of family history and BMI on diabetes. Conclusions: When exposed to both family history and overweight/obesity, individuals would have an increased risk that was greater than the sum of their single effects. Reduction of BMI would also reduce the risk of diabetes associated family history.

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“…In this study, we found that there is very little awareness of the fact that family history is a risk factor for hypertension and diabetes. Family history is among the strongest risk factors for the development of hypertension and diabetes . A population‐based survey among 5389 adults in The Gambia found that a significant number of subjects with a family history of hypertension had a higher diastolic BP, body mass index, higher cholesterol, and uric acid concentrations than those without such family history .…”

Section: Discussionmentioning

confidence: 99%

Using community pharmacies to expand access to screening for noncommunicable diseases in suburban Ghana—A facility‐based survey on client needs and acceptability

Akutey

Der

Owusu-Daaku

et al. 2018

Health Science Reports

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BackgroundMany of the 28 million deaths from noncommunicable diseases (NCDs) in low‐ and middle‐income countries each year could be prevented through early detection and intervention. The introduction of screening for NCDs in community pharmacies (CPs) in Ghana could enhance access to early detection.MethodsWe surveyed clients in three districts in suburban Ghana to assess perceived need for screening, willingness to be screened in CPs, and willingness to receive NCD health promotion information through text messages (NCD m‐Health). We performed regression analysis to identify predictors of NCD m‐Health acceptability.ResultsWe interviewed 330 clients in six CPs, 134 (42.3%) of whom were females. The median age was 34 years (interquartile range, 27‐43). Fifty‐four (16.4%) had no formal education. Although most respondents knew obesity (74.9%), smoking (81.9%), and excessive dietary salt (91.7%) were risk factors for NCDs, only 27.0% knew family history carried similar risk. Most respondents, 61.6% and 70.6%, respectively, had not had their weight and blood pressure (BP) checked for more than 12 months. These included about a third of respondents who were known hypertensives. Similarly, 71.3% of 80 participants with a family history of hypertension had not had their BPs checked. Screening for NCDs in CPs and the sending of NCD m‐Health messages was deemed acceptable to 98.5% and 83.1% of the participants, respectively. Formal education beyond junior high school (Grade 9) was the strongest independent predictor of NCD m‐Health acceptance (OR = 4.77; 95% CI, 1.72‐13.18; P value < 0.01). One hundred and twenty‐five (39.4%) participants indicated they would consider unsolicited NCD m‐Health messages an invasion of their privacy.ConclusionAn urgent need exists to promote access to NCD screening in these communities. Its introduction into CPs is acceptable to nearly all the clients surveyed. The introduction of NCD m‐Health as an accompaniment requires consideration for the privacy of clients.

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Increased Risk of Type 2 Diabetes From a Family History of Coronary Heart Disease and Type 2 Diabetes

Cited by 17 publications

References 24 publications

Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Synergy of BMI and family history on diabetes: the Humboldt Study

Using community pharmacies to expand access to screening for noncommunicable diseases in suburban Ghana—A facility‐based survey on client needs and acceptability

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