Increased risk of venous thromboembolism in splenectomized patients with sickle cell disease

Tennenbaum, Juliette; Volle, Geoffroy; Pouchot, J.; Joseph, Laure; Khimoud, Djamal; Ranque, Brigitte; Arlet, Jean‐Benoît

doi:10.1111/bjh.18743

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2024

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Cited by 4 publications

References 14 publications

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Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias

2024

Haemoglobinopathy Diagnosis

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Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias

2024

Haemoglobinopathy Diagnosis

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Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat

Bou‐Fakhredin,

Cappellini,

Taher

et al. 2024

American J Hematol

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Beta (β)‐thalassemia and sickle cell disease (SCD) are characterized by a hypercoagulable state, which can significantly influence organ complication and disease severity. While red blood cells (RBCs) and erythroblasts continue to play a central role in the pathogenesis of thrombosis in β‐thalassemia and SCD, additional factors such as free heme, inflammatory vasculopathy, splenectomy, among other factors further contribute to the complexity of thrombotic risk. Thus, understanding the role of the numerous factors driving this hypercoagulable state will enable healthcare practitioners to enhance preventive and treatment strategies and develop novel therapies for the future. We herein describe the pathogenesis of thrombosis in patients with β‐thalassemia and SCD. We also identify common mechanisms underlying the procoagulant profile of hemoglobinopathies translating into thrombotic events. Finally, we review the currently available prevention and clinical management of thrombosis in these patient populations.

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A comprehensive view of pregnancy in patients with sickle cell disease in high-income countries: the need for robust data and further decline in morbidity and mortality

Joseph,

Driessen

2024

The Lancet Haematology

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Increased risk of venous thromboembolism in splenectomized patients with sickle cell disease

Cited by 4 publications

References 14 publications

Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias

Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias

Hypercoagulability in hemoglobinopathies: Decoding the thrombotic threat

A comprehensive view of pregnancy in patients with sickle cell disease in high-income countries: the need for robust data and further decline in morbidity and mortality

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