Increased sensitivity to alprazolam in females with a paternal history of alcoholism

Evans, Suzette M.; Levin, Frances R.; Fischman, Marian W.

doi:10.1007/s002130000421

Cited by 16 publications

(24 citation statements)

References 32 publications

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“…Performance Measures-All of the performance measures described below, with the exception of the Word Recall task, were conducted at baseline, 0.5, 1, 2, 3, and 4 h during each session (see Evans et al, 2000 …”

Section: Profile Of Mood States (Poms)mentioning

confidence: 99%

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Reed

Levin

Evans

2008

Hormones and Behavior

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142

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Although it's been reported that women with premenstrual dysphoric disorder (PMDD) have increased negative mood, appetite (food cravings and food intake), alcohol intake and cognitive deficits premenstrually, few studies have examined these changes concurrently within the same group of women or compared to women without PMDD. Thus, to date, there is not a clear understanding of the full range of PMDD symptoms. The present study concurrently assessed mood and performance tasks in 29 normally cycling women (14 women who met DSM-IV criteria for PMDD and 15 women without PMDD). Women had a total of ten sessions: two practice sessions, 4 sessions during the follicular phase and 4 sessions during the late luteal phase of the menstrual cycle. Each session, participants completed mood and food-related questionnaires, a motor coordination task, performed various cognitive tasks and ate lunch. There was a significant increase in dysphoric mood during the luteal phase in women with PMDD compared to their follicular phase and compared to Control women. Further, during the luteal phase, women with PMDD showed impaired performance on the Immediate and Delayed Word Recall Task, the Immediate and Delayed Digit Recall Task and the Digit Symbol Substitution Test compared to Control women. Women with PMDD, but not Control women, also showed increased desire for food items high in fat during the luteal phase compared to the follicular phase and correspondingly, women with PMDD consumed more calories during the luteal phase (mostly derived from fat) compared to the follicular phase. In summary, women with PMDD experience dysphoric mood, a greater desire and actual intake of certain foods and show impaired cognitive performance during the luteal phase. An altered serotonergic system in women with PMDD may be the underlying mechanism for the observed symptoms; correspondingly, treatment with specific serotonin reuptake inhibitors (SSRIs) remains the preferred treatment at this time.

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Section: Profile Of Mood States (Poms)mentioning

confidence: 99%

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Reed

Levin

Evans

2008

Hormones and Behavior

Self Cite

142

View full text Add to dashboard Cite

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“…To have all scales on a similar 5-point scale, total scores for each of the eight major scales were divided by the number of items used to determine the scale score. During each assessment battery after dosing, participants also completed a Drug Effect Questionnaire (DEQ; see Evans et al 2000 for details).…”

Section: Assessment Batterymentioning

confidence: 99%

“…The performance measures included four computerized tasks and one non-computerized task (see Evans et al 2000 for details). All of the performance measures described below, with the exception of the word recall task, were conducted during the experimental sessions before drug administration and 0.5, 1, 2, 3 and 4 h after drug administration.…”

Section: Assessment Batterymentioning

confidence: 99%

“…While these findings were intriguing, they were somewhat inconsistent with the preponderance of evidence indicating that FHP individuals are less sensitive to alcohol than FHN individuals. Using the same procedures and measures as in our previous study with alprazolam (Evans et al 2000), the purpose of the present study was to determine if FHP females were less sensitive to alcohol compared to FHN females. The present study attempted to improve upon previous alcohol challenge studies by testing more women (16 in each group) than previous studies, insuring homogenous groups by carefully matching participants and controlling for drinking level, confirming the presence or lack of a first-degree history of alcoholism and ruling out the potential confound of a maternal history of alcoholism in the FHP group.…”

Section: Introductionmentioning

confidence: 98%

“…In a previous study (Evans et al 2000), we assessed the role of a paternal history of alcoholism in response to the benzodiazepine alprazolam among FHP (n=14) and FHN females (n=14). Alprazolam produced more impairment on psychomotor performance tasks (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Response to alcohol in females with a paternal history of alcoholism

Evans

Levin

2003

Psychopharmacology

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Current Awareness

2001

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Increased sensitivity to alprazolam in females with a paternal history of alcoholism

Abstract: In contrast to many previous findings with FHP males, these results suggest that FHP females may be more sensitive to the performance-impairing effects and negative subjective effects of alprazolam.

Cited by 16 publications

References 32 publications

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Response to alcohol in females with a paternal history of alcoholism

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