Increased Serum Cancer Antigen-125 Is a Marker for Severity of Deep Endometriosis

Santulli, Piétro; Streuli, Isabelle; Melonio, Isabelle; Marcellin, Louis; Mbaye, Magatte; Bititi, Amine; Borghese, Bruno; Pillet, Marie-Christine Lafay; Chapron, Charles

doi:10.1016/j.jmig.2014.10.013

Cited by 36 publications

(28 citation statements)

References 39 publications

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“…9,11,12,[14][15][16][17][18][19][20][21][22] All studies evaluated CA125, four studied CA19-9, 9,11,12,20 and two CA15-3.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Airong

et al. 2015

J Int Med Res

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Aim: To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis. Methods: Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed Õ and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV). Results: The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84). Conclusions: Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.

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“…9,11,12,[14][15][16][17][18][19][20][21][22] All studies evaluated CA125, four studied CA19-9, 9,11,12,20 and two CA15-3.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Airong

et al. 2015

J Int Med Res

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“…Serum cancer antigen 125 (CA 125) is widely used in the assessment of adnexal masses, despite its modest sensitivity and positive predictive value (PPV) for early‐stage epithelial ovarian cancer (EOC) and its low specificity due to the high levels of this biomarker in patients with endometriosis, early pregnancy, leiomyoma, hepatobiliary disease and malignancy other than ovarian cancer, and in menstruating women. Recently, a more specific biomarker for ovarian cancer, human epididymis protein 4 (HE4), was introduced.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Piovano

Cavallero

Fuso

et al. 2017

Ultrasound in Obstet & Gyne

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“…CA 125 is raised in endometriosis through stimulation of coelomic epithelia and is the most investigated non‐invasive diagnosis marker. Individual studies have methodological limitations in patient selection, poor conduct of the index test, and poor conduct of the reference test . Two diagnostic reviews exist; however, the first is over 15 years old and includes studies with high risk of verification bias and the second is of poor methodological quality …”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

110

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Increased Serum Cancer Antigen-125 Is a Marker for Severity of Deep Endometriosis

Cited by 36 publications

References 39 publications

Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Diagnostic accuracy and cost‐effectiveness of different strategies to triage women with adnexal masses: a prospective study

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

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