Increased Serum Chitotriosidase Activity following Restoration of Euthyroidism in Patients with Subclinical Hypothyroidism

Erdal, Muhammed; Şahi̇n, Mustafa; Sağlam, Kenan; Haşimi, Adnan; Üçkaya, Gökhan; Yarpuz, Mustafa Yalcin; Taşlıpınar, Abdullah; Gharib, Hossein; Kutlu, Mustafa

doi:10.2169/internalmedicine.47.1013

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 36 articles initially selected, 12 studies were finally identified that met the inclusion criteria (▶Fig. 1) [10][11][12][13][14][15][16][17][18][19][20][21]. The characteristics of the subjects in both the SCH and euthyroid groups are summarized with the results in ▶table 1.…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Hyperhomocysteinemia is proposed as a risk factor for CVD in those with overt hypothyroidism; yet, as SCH and overt hypothyroidism have a similar etiology, the tHcy level may also be valuable in patients with SCH. However, it is controversial whether SCH is associated with hyperhomocysteinemia; a few studies have shown that the tHcy level is elevated in those with SCH [10][11][12][13], while others have conflicting findings [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

Shou-fa

Liu

Zhang³

et al. 2020

Horm Metab Res

View full text Add to dashboard Cite

AbstractIncreased plasma homocysteine (Hcy) levels have been widely documented in patients with overt hypothyroidism; however, the significance of Hcy level changes in patients with subclinical hypothyroidism (SCH) remains controversial. The aim of this meta-analysis was to determine the Hcy status in patients with SCH compared with euthyroid subjects. We searched PubMed, Embase, and Cochrane Library databases prior to December 2019 to identify eligible studies and assessed the quality of selected studies using the Newcastle-Ottawa Quality Assessment Scale. Publication bias was evaluated by Begg’s test and Egger’s test. Meta-regression analysis was conducted to investigate the source of heterogeneity. A likely source of heterogeneity was the year of the study. All statistical analyses were performed with RevMan 5.3 and Stata 12.0 software. Our meta-analysis of twelve observational studies with 684 patients showed that those with SCH aged between 18 and 65 years old were associated with a slightly increased plasma Hcy level compared with euthyroid controls. The pooled result of the weighted mean difference (WMD) of increased tHcy levels was 1.16 μmol/l (95% CI: 0.51, 1.82; p=0.0005). The Hcy level in patients with SCH aged between 18 and 65 years old is significantly increased compared to euthyroid controls.

show abstract

Section: Study and Patient Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

Shou-fa

Liu

Zhang³

et al. 2020

Horm Metab Res

View full text Add to dashboard Cite

show abstract

Subclinical hypothyroidism and subclinical hyperthyroidism

Fatourechi¹

2010

Expert Review of Endocrinology & Metabolism

View full text Add to dashboard Cite

Subklinik hipotiroidi kadınlarda dislipidemiye neden olmayabilir

Aydoğdu¹

2010

Turk J Fam Pract

View full text Add to dashboard Cite

Amaç: Tiroid hormonu eksikli¤i lipid peroksidasyonunu azaltarak hiperlipidemiye yol açabilir. Bu nedenle antitiroid antikorlar› saptanan ötiroid ve subklinik hipotiroid (SH) kiflilerin lipid parametrelerini sa¤l›kl› bireylerle karfl›laflt›rd›k. Yöntem: Çal›flma, tiroid antikoru yüksek 42 ötiroid kad›n (1. grup) (yafl: 37.2±7.2, vücut kitle indeksi (VK‹): 24.2±2.9 kg/m 2), tiroid antikoru yüksek 50 SH kad›n (2. grup) (yafl: 35.4±3, VK‹: 24.1±3.0 kg/m 2) ile herhangi bir metabolik hastal›¤› bulunmayan, tiroid antikoru negatif, 72 sa¤l›kl› kad›n (3. grup) (yafl: 37.8±10.5, (VK‹): 23.3±2.8kg/m 2) ile yürütüldü. Serum örneklerinde kolesterol (K), düflük yo¤unluklu lipoprotein (LDL-K), yüksek yo¤unluklu lipoprotein (HDL)-K, non-HDL-K, trigliserid düzeyleri ve total-K /HDL-K oranlar›na bak›ld›. Bulgular: 2. grupta HDL-K (mg/dl) düzeyi di¤er gruplardan istatistiki olarak anlaml› derecede düflük, (HDL-KGrup1=65.4±13.5, HDL-KGrup2=54.9±11.8, HDL-KGrup3=62.2±4.6, p=0.002), trigliserid (mg/dl) düzeyi 2. grupta 1. gruptan anlaml› derecede yüksekti; (trigliseridGrup1=79.4±29.1, trigliseridGrup2=114±59; p=0.017). Total-K/HDL-K oran›, 2. grupta di¤er gruplardan belirgin olarak yüksekti (Total-K/HDL-KGrup1=3.0±0.6, Total-K/HDL-KGrup2=3.4±0.7, Total-K/HDL-KGrup3=2.7±0.7; p=0.001). TSH ile total-K/HDL-K ora-n› aras›nda pozitif, TSH ile HDL-K düzeyi aras›nda negatif (r=0.265, p=0.023/r=-0.291, p=0.012), ST4 ile total-K /HDL-K oran› aras›nda negatif korelasyon saptand› (r=-0.233, p=0.046). Sonuç: Olgular›n lipid parametrelerinin ortalamalar› kontrol grubundan yüksek olmakla birlikte normal s›n›rlar içinde olmalar›, tek bafl›na SH'nin dislipidemi yapmayabilece¤ini düflündürmektedir. Bu bulgular ›fl›¤›nda, Subklinik hipotiroidide efllik eden hastal›kla-r›n daha yak›ndan izlenmesi ve tedavisi kalp-damar hastal›klar›ndan korunmada gerçekçi bir yaklafl›m olabilir.

show abstract

Increased Serum Chitotriosidase Activity following Restoration of Euthyroidism in Patients with Subclinical Hypothyroidism

Abstract: Objective Whether to treat subclinical hypothyroidism (SH)

Cited by 3 publications

References 37 publications

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

Subclinical hypothyroidism and subclinical hyperthyroidism

Subklinik hipotiroidi kadınlarda dislipidemiye neden olmayabilir

Contact Info

Product

Resources

About