Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus

Abstract

Aims/Introduction Asprosin is a novel secreted adipokine that is induced by fasting and promotes hepatic glucose release. In healthy humans, circulating asprosin shows circadian oscillation with an acute drop coinciding with the onset of eating. The present study investigated whether this circadian oscillation still exists in patients with type 2 diabetes mellitus. Materials and Methods We recruited 60 patients with type 2 diabetes mellitus and 60 individuals with normal glucose tolerance (NGT). All participants completed a 75‐g oral glucose tolerance test. Fasting and 2‐h postprandial serum asprosin concentrations were measured by the enzyme‐linked immunosorbent assay method. Partial correlation coefficients were calculated to analyze the relationships between serum asprosin level and parameters of glucose metabolism. Multiple logistic regression analysis was used to determine the association of serum asprosin level with diabetes. Results Both fasting and postprandial asprosin levels were significantly higher in patients with type 2 diabetes mellitus. The postprandial asprosin level was apparently lower than fasting asprosin level in individuals with NGT. The fasting asprosin level closely correlated with type 2 diabetes mellitus after multiple adjustment (odds ratio 2.329, P = 0.023). Asprosin correlated negatively with change in blood glucose (r = −0.502, P < 0.001) and change in C‐peptide (r = −0.467, P < 0.001) in individuals with NGT, but not in type 2 diabetes mellitus patients. Conclusions Serum asprosin level decreased coinciding with the onset of the oral glucose tolerance test in individuals with NGT, whereas this circadian oscillation was disturbed in type 2 diabetes mellitus patients. The impaired response of asprosin to glucose fluctuation in type 2 diabetes mellitus patients might be one of the reasons for the onset of type 2 diabetes mellitus.

Asprosin: A Novel Player in Metabolic Diseases

“…In addition, a hospitalbased case-control study including 170 subjects also showed higher serum asprosin concentrations in adults with T2DM when compared with controls, and independent association between fasting glucose and serum asprosin in T2DM, which is consistent with numerous studies (14)(15)(16)(17). Furthermore, there is an impaired or blunted response of serum asprosin levels to the fluctuation of blood glucose in type 1 diabetes mellitus (T1DM) and T2DM patients (16,18). Recently, it has been reported that the serum asprosin levels of pregnant women with GDM and their newborns' umbilical cords are higher than controls (19).…”

“…Asprosin was positively associated with the homeostasis model assessment for IR (HOMA-IR), while negatively related to the homeostasis model assessment for β-cell function (HOMA-β) (14). In addition, a hospitalbased case-control study including 170 subjects also showed higher serum asprosin concentrations in adults with T2DM when compared with controls, and independent association between fasting glucose and serum asprosin in T2DM, which is consistent with numerous studies (14)(15)(16)(17). Furthermore, there is an impaired or blunted response of serum asprosin levels to the fluctuation of blood glucose in type 1 diabetes mellitus (T1DM) and T2DM patients (16,18).…”

Anti-Atherosclerotic Properties of Wild Rice in Low-Density Lipoprotein Receptor Knockout Mice: The Gut Microbiome, Cytokines, and Metabolomics Study

“…Another observation was a significant increase in plasma glucose concentrations in the wild rice fed mice as compared to that in the control group. Increased plasma glucose levels are seen during diabetes or insulin resistance in animals as well as humans [37,38]. However, the consumption of high fiber diets is generally recommended to combat complications that are caused by diabetes [39,40].…”

Role and significance of asprosin in feeding behaviour and metabolism

“…Так, Zhang и соавт. отметили положительное антифибротическое действие аспросина на миокард в постинфарктный период [21].…”