Increased serum levels of advanced oxidation protein products and glycation end products in subjects exposed to low-dose benzene

Oxidative stress markers are increased in patients with mastocytosis

“…AGEs and AOPPs were measured by spectrofluorimetric and spectrophotometric methods, respectively, as previously described .…”

“…Biomarkers of oxidative stress can be classified as molecules that are modified by interactions with ROS in the microenvironment and molecules of the antioxidant system that change in response to increased redox stress. Advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEs) are a family of compounds generated in body fluids by the transformation of macromolecules, including proteins, used as markers of oxidative stress and inflammation in several diseases . These compounds are often functionally inactive and display either increased or reduced sensitivity to protease degradation.…”

Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?

“…A separate possibility is for the benzene oxide to undergo ring opening to produce trans, trans-mucoaldehyde, which can spontaneously rearrange to form PH, which is hydroxylated in the liver to form HQ. 9 Catalyzed by phase II metabolic enzymes, such as glutathione S-transferase (GST), these benzene metabolites are easily conjugated with glutathione or glucuronide to form less toxic or non-toxic derivatives 10,11 excreted in urine.…”

Involvement of new oxidative stress markers in chronic spontaneous urticaria

“…The AGEs are composed of a heterogeneous group of bioactive compounds (e.g., pentosidine, carboxymethyl lysine, and imidazolone) that are formed by nonenzymatic glycation of macromolecules [ 8 ]. Formation of AGEs is markedly increased in hyperglycaemia but today there is increasing evidence that formation of AGEs has a role also in pathogenesis of several different diseases accompanied by oxidative stress and inflammation, including atherosclerosis, chronic obstructive pulmonary disease, rheumatoid arthritis, and multiple sclerosis [ 26 – 32 ].…”

“…Determination of AGEs and AOPPs was based on spectrofluorimetric and spectrophotometric methods, respectively, as previously described [ 26 ]. For AGE determination, serum was diluted 1 : 50 with phosphate buffered saline (PBS; pH 7.4), and fluorescence intensity was recorded at maximum emission (~440 nm) upon excitation at 350 nm and expressed in arbitrary units (AU).…”