Increased serum levels of miR-1266 in patients with psoriasis vulgaris

Ichihara, Asako; Jinnin, Masatoshi; Oyama, Rie; Yamane, Keitaro; Fujisawa, Akihiko; Sakai, Keisuke; Masuguchi, Shinichi; Fukushima, Satoshi; Maruo, Keishi; Ihn, Hironobu

doi:10.1684/ejd.2011.1600

Cited by 51 publications

(49 citation statements)

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“…Papagregoriou et al 34 demonstrated that miR-1207-5p directly represses heparin-binding epidermal growth factor (HBEGF) expression and is associated with disease severity in C3-glomerulopathy. Ichihara et al 35 reported that serum miR-1266 level was considerably higher in psoriasis patients than in healthy control subjects. Our studies are the first to reveal a role for these miRNAs as cancer suppressors, and the discovery that miR-1207-5p and miR-1266 target hTERT may provide novel insights into their roles in C3-glomerulopathy.…”

Section: Discussionmentioning

confidence: 99%

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

et al. 2014

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hTERT is the catalytic subunit of the telomerase complex. Elevated expression of hTERT is associated with the expansion and metastasis of gastric tumor. In this study, we aimed to identify novel tumor suppressor miRNAs that restrain hTERT expression. We began our screen for hTERT-targeting miRNAs with a miRNA microarray. miRNA candidates were further filtered by bioinformatic analysis, general expression pattern in different cell lines, gain-of-function effects on hTERT protein and the potential of these effects to suppress hTERT 3′ untranslated region (3′UTR) luciferase activity. The clinical relevance of two miRNAs (miR-1207-5p and miR-1266) was evaluated by real-time RT-PCR. The effects of these miRNAs on cell growth, cell cycle and invasion of gastric cancer cells were measured with CCK-8, flow cytometry and transwell assays. Finally, the ability of these miRNAs to suppress the transplanted tumors was also investigated. Fourteen miRNAs were identified using a combination of bioinformatics and miRNA microarray analysis. Of these fourteen miRNAs, nine were expressed at significantly lower levels in hTERT-positive cell lines compared with hTERT-negative cell lines and five could downregulate hTERT protein expression. Only miR-1207-5p and miR-1266 interacted with the 3′ UTR of hTERT and the expression levels of these two miRNAs were significantly decreased in gastric cancer tissues. These two miRNAs also inhibited gastric tumor growth in vitro and in vivo. Altogether, miR-1207-5p and miR-1266 were determined to be hTERT suppressors in gastric cancer, and the delivery of these two miRNAs represents a novel therapeutic strategy for gastric cancer treatment.

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Section: Discussionmentioning

confidence: 99%

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

et al. 2014

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“…it was reported that serum miR‐424 reflected the proliferative activity of keratinocytes. In the later study, they reported serum levels of miR‐1266, a putative regulator of IL‐17A, in patients with psoriasis showed weak inverse correlations with PASI scores and Body Surface Areas (BSA) . In the similar disease scleroderma, Takemoto et al .…”

Section: Mirna As Potential Biomarkers In Psoriasismentioning

confidence: 99%

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

Liu

Han

et al. 2017

Experimental Dermatology

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MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.

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“…Among these miRNAs, miR‐203, miR‐146a, miR‐31, miR‐21, miR‐210 and miR‐369‐3p are increased, and miR‐125b is decreased in psoriasis compared to controls. These miRNAs regulate inflammatory autoimmune process via distinct pathways or/and targets (Table ).…”

Section: Mirnas In Autoimmune Diseases With Skin Involvementmentioning

confidence: 99%

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

Deng

et al. 2015

Scand J Immunol

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MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively modulate gene expression by binding to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs), which leads to the degradation or translational repression of their target mRNAs. Previous research on miRNAs has revealed a new paradigm of gene regulations and pathways involved in the pathogenesis of autoimmune disorders and malignant diseases. The roles of miRNAs in cellular processes, including cell differentiation, proliferation, apoptosis and immune functions, are not clearly understood. MiRNAs are easily detected in a variety of sources, including tissues, serum and other body fluids, and this make them a good biological sample for pathogenic studies and disease biomarker development. This review encompasses the current understanding of the roles of miRNAs in autoimmunity and the cellular and molecular mechanisms of miRNAs in various autoimmune diseases (AIMDs). Specifically, we focus on the target genes of miRNAs and the biological processes associated with autoimmune diseases with skin involvement, including systemic lupus erythematosus, psoriasis, systemic sclerosis, Behcet's disease and dermatomyositis. In addition, the diagnostic and therapeutic relevance of miRNAs that are involved in autoimmunity are elucidated to provide information for clinical implications.

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Increased serum levels of miR-1266 in patients with psoriasis vulgaris

Cited by 51 publications

References 0 publications

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

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