Increased Serum Soluble Transferrin Receptor Levels Were Associated With High Prevalence of Cardiovascular Diseases: Insights From the National Health and Nutrition Examination Survey 2017–2018

Zhu, Shiyu; Liu, Chang; Zhao, Chengchen; Chen, Guanzhong; Meng, Simin; Ma, Hong; Xiang, Meixiang; Xie, Yao

doi:10.3389/fcell.2022.874846

Cited by 13 publications

(7 citation statements)

References 46 publications

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“…Nevertheless, the incidence of hereditary methylmalonic acidemia was very low in the general population, therefore it is unlikely to alter the result. Third, same to the previous studies ( 42 , 43 ), CVDs were identified by self-reporting, which may elicit recall and interviewer bias. But the diagnosis of CVDs was consistent throughout the study.…”

Section: Discussionmentioning

confidence: 96%

Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Wang

Xiang

2022

Front. Cardiovasc. Med.

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BackgroundFunctional vitamin B12 deficiency is common in cardiovascular diseases (CVDs), such as heart failure and myocardial infarction. Methylmalonic acid (MMA) is a specific and sensitive marker of vitamin B12 deficiency. However, there are scarce data in regard to the relationship between MMA and CVDs.Materials and methodsIn this cross-sectional study, we analyzed data of 5,313 adult participants of the National Health and Nutrition Examination Survey (NHANES) 2013–2014. Associations between MMA and other variables were assessed with linear regression models. Univariable and multivariable logistic regression models were employed to explore the association between MMA and CVDs.ResultsThe weighted prevalence of CVDs was 8.8% in the general population of the USA. Higher MMA levels were found in participants with CVDs (p < 0.001). Linear regression models revealed positive associations between serum MMA level and age (p < 0.001), glycohemoglobin (p = 0.023), fasting glucose (p = 0.044), mean cell volume (p = 0.038), and hypertension (p = 0.003). In the multivariable logistic model adjusting for age, gender, ethnicity, smoking, hypertension, glycohemoglobin, body mass index (BMI), low-density lipoprotein-cholesterol (LDL-C), renal dysfunction and vitamin B12, serum MMA (adjusted odds ratio, 3.08; 95% confidence interval: 1.63–5.81, p = 0.002, per ln nmol/L increment) was associated with CVDs.ConclusionOur study demonstrated that elevated serum MMA levels were independently associated with the presence of CVDs and may be used to predict the occurrence of CVDs.

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Section: Discussionmentioning

confidence: 96%

Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Wang

Xiang

2022

Front. Cardiovasc. Med.

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“…19 Elevated sTfR levels are associated with a higher prevalence of cardiovascular disease. 20 In the Chinese Health and Nutrition Examination Survey study, sTfR levels were shown to be positively correlated with systolic and diastolic blood pressure at baseline, and high sTfR levels independently predicted hypertension onset. 21 Therefore, elevated sTfR in GDM+PE patients shares a common pathway with cardiovascular diseases in elderly individuals, as pregnancy might predispose women to a high risk of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 98%

Early Gestational Blood Markers to Predict Preeclampsia Complicating Gestational Diabetes Mellitus

Xie¹,

Zhou²,

Tao³

et al. 2023

DMSO

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Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications that share some common risk factors. GDM patients are also at high risk for PE. There are no sensitive markers for prediction, especially for the occurrence of PE in GDM patients. This study investigated plasma proteins for the prediction of PE in GDM patients. Methods: A total of 10 PE, 10 GDM, and 5 PE complicated with GDM cases, as well as 10 pregnant controls without obvious complications, were included in the nested cohort. The proteomics in the plasma collected at 12-20 weeks of gestational age (GA) were analyzed by liquid chromatography-mass spectrometry/mass spectrometry. Some potential markers, such as soluble transferrin receptor (sTfR), ceruloplasmin (CP), apolipoprotein E (ApoE) and inositol 1,4,5-trisphosphate receptor 1 (ITPR1), were validated using enzyme-linked immunosorbent assays. Results: Functional analysis of the plasma showed that proteasome activation, pancreatic secretion, and fatty acid degradation were activated in the GDM group, and renin secretion-, lysosome-, and proteasome pathways involving iron transport and lipid metabolism were enriched in the PE group, distinguishing PE complicating GDM. Conclusion: Through proteomics analysis of plasma in early pregnancy, PE complicating GDM may have a unique mechanism from that of PE alone. Plasma sTfR, CP and ApoE levels have potential clinical applications in early screening.

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“…The concentration of sTFR can re ect the demand of cells for iron and is a good indicator of functional iron de ciency [31,32]. In recent years, many studies have shown that elevated sTFR levels were associated with the high prevalence of cardiovascular diseases [33,34]. In the 24th week, although the proportion of patients with absolute iron de ciency did not increase signi cantly, the sTFR level increased signi cantly, suggesting that iron de ciency occurred in PD patients with the increase in iron utilization, and appropriate iron supplementation may be necessary.…”

Section: Discussionmentioning

confidence: 99%

Effect of roxadustat on iron metabolism in patients with peritoneal dialysis: A real- world 24-week study

Zhang,

Jia,

Zheng

et al. 2023

Preprint

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Background Roxadustat is an oral hypoxy inducing factor-prolyl hydroxylase inhibitor (HIF-PHI) that regulates iron metabolism in patients with chronic kidney disease (CKD) primarily by reducing hepcidin levels and mobilizing internal iron stores. More data are needed to demonstrate the efficacy of roxadustat in regulating iron metabolism in patients with peritoneal dialysis (PD) compared with erythropoiesis stimulating agents (ESAs). Methods This prospective cohort study enrolled PD patients with a mean hemoglobin level of 60 to 100 g/L. All subjects were randomized into two groups at a ratio of 2:1: the roxadustat group (106 cases), and the ESA group (53 cases). The primary endpoint was the change in the iron biomarker levels and the proportion of patients with absolute iron deficiency and functional iron deficiency. Results Compared with ESAs, roxadustat significantly decreased hepcidin level (difference,-20.09ng/mL; 95% CI, -30.26 to -9.92), attenuated the increase in serum soluble transferrin receptor (sTFR) level (difference, -7.87 nmol/L; 95% CI, -12.11 to -3.64), and reduced the proportion of patients with functional iron deficiency (roxadustat, 11.43%; ESA, 33.33%). There was no significant difference in safety of the two groups over the duration of the study. Conclusions Compared with ESA group, roxadustat group showed significant difffferences in all iron biomarker levels except serum ferritin (sFt) and transferrin saturation (TSAT). These results suggest that roxadustat was superior to ESAs as a therapy for iron metabolism in PD patients. Trial registration: This study completed Chinese Clinical Trial Registration on March 4,2022 (registration number: ChiCTR2200057231).

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Increased Serum Soluble Transferrin Receptor Levels Were Associated With High Prevalence of Cardiovascular Diseases: Insights From the National Health and Nutrition Examination Survey 2017–2018

Cited by 13 publications

References 46 publications

Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Early Gestational Blood Markers to Predict Preeclampsia Complicating Gestational Diabetes Mellitus

Effect of roxadustat on iron metabolism in patients with peritoneal dialysis: A real- world 24-week study

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