Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation

Wada, Hideo; Sase, Tomohiro; Matsumoto, Toshifumi; Kushiya, Fumihiko; Sakakura, Miho; Mori, Yoshitaka; Nishikawa, Masakatsu; Ohnishi, Katsuya; Nakatani, Kaname; Gabazza, Esteban C.; Shiku, Hiroshi; Nobori, Tsutomu

doi:10.1177/107602960300900308

Cited by 33 publications

(37 citation statements)

References 29 publications

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“…Low concentrations of crosslinked fibrin derivatives containing D-dimer are detected in normal blood, and high levels are found in patients with DIC and in the majority of patients having deep vein thrombosis or pulmonary embolism (Elms, 1983, Wada et al 2003, Akman et al 2004. To aid in the diagnosis and evaluation of DIC and other conditions, a monoclonal antibody coated-latex agglutination assay specific for Ddimer has been widely and clinically employed (Ikematsu andKuroso, 1989, Bates et al 2001).…”

Section: Introductionmentioning

confidence: 97%

Usefulness of a latex agglutination assay for FDP D-dimer to demonstrate the presence of postmortem blood

et al. 2005

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D-dimer, a specific fragment resulting from degradation of cross-linked fibrin, is an essential marker for the diagnosis of disseminated intravascular coagulation (DIC). Rapid assay for D-dimer using monoclonal antibody coated-latex particles might be useful for discriminating between postmortem and antemortem blood in bloodstains. We tried to detect D-dimer in nine postmortem blood samples by the rapid latex agglutination assay and to quantify them automatically using the latex photometric immunoassay system. The results showed that all samples were positive and that their amounts of D-dimer were 335-2,800 microg/ml (the normal blood level, <1 microg/ml; the pathogenic blood level with DIC, 1-100 microg/ml). Next, nine stains made of postmortem blood were examined by the rapid latex agglutination assay. The result showed that only one case (D-dimer 335 microg/ml blood) showed weak positive while the others (D-dimer 600-2,800 microg/ml blood) were positive. The present study indicates that the latex agglutination assay for D-dimer can be useful to demonstrate the presence of postmortem blood.

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Section: Introductionmentioning

confidence: 97%

Usefulness of a latex agglutination assay for FDP D-dimer to demonstrate the presence of postmortem blood

et al. 2005

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“…These markers are reported to be elevated in deep vein thrombosis (DVT)/pulmonary embolism (PE) [3][4][5], disseminated intravascular coagulation (DIC) [6][7][8], acute myocardial infarction (AMI) [9,10] and thrombotic thrombocytopenic purpura (TTP) [11]. The International Society of Thrombosis and Haemostasis (ISTH) established the diagnostic criteria for overt-DIC using SF and D-dimer [12].…”

Section: Introductionmentioning

confidence: 99%

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

et al. 2009

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Soluble fibrin (SF) and D-dimer are considered to be useful for the diagnosis of thrombosis; however, the efficacy of the diagnosis of deep vein thrombosis (DVT) after orthopaedic surgery by SF and D-dimer is still not well established. The present study was designed to evaluate the efficacy of SF and D-dimer in the diagnosis of DVT after orthopaedic surgery. The plasma concentrations of SF and D-dimer were measured in 99 patients following orthopaedic surgery. The plasma concentrations of D-dimer and SF in patients undergoing orthopaedic surgery were markedly high in comparison to healthy volunteers, and these markers were increased after surgery. The plasma concentrations of D-dimer were significantly higher in patients with DVT than in those without DVT at days 4, 7, 10 and 14, and those of SF were significantly higher in patients with DVT than in those without DVT at days 1, 4 and 14. A receiver operating characteristic (ROC) analysis of SF and D-dimer for diagnosis of DVT after surgery generated an ROC curve that showed SF to be better than D-dimer at day 1, while D-dimer was better than SF at day 4. In addition, less than 7.2 microg/ml of D-dimer or 3.6 microg/ml of SF at day 1 after surgery, or less than 7.0 microg/ml of D-dimer at day 4 excluded DVT. These findings suggest that the D-dimer and SF are useful for the diagnosis and exclusion of DVT after orthopaedic surgery.

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“…The FRMs are reported to be elevated in deep vein thrombosis (DVT)/pulmonary embolism (PE) [3][4][5], disseminated intravascular coagulation (DIC) [6][7][8], acute myocardial infarction (AMI) [9,10] and thrombotic thrombocytopenic purpura (TTP) [11]. The International Society of Thrombosis and Haemostasis (ISTH) established the diagnostic criteria for overt-DIC using FRM [12].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of soluble fibrin in patients with venous thromboembolism

et al. 2008

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The fibrin-related markers (FRMs), including soluble fibrin (SF), D-dimer and fibrin and fibrinogen degradation products (FDP) are considered to be useful for the diagnosis of thrombosis; however, evidence for the diagnosis of thrombosis by SF is still not well established. The present study was designed to evaluate the usefulness of SF in the diagnosis of venous thromboembolism (VTE). The plasma concentrations of FRMs were measured in 551 in-patients suspected to have a VTE. The plasma levels of SF, D-dimer and FDP were significantly higher in patients with VTE than patients without VTE and those were significantly higher in patients without VTE than in healthy volunteers. In a receiver operating characteristic analysis for the diagnosis of VTE, the area under the curve was 0.950 for SF, 0.933 for FDP and 0.805 for D-dimer. The appropriate cut-off values for the diagnosis were as follows SF 5.9 microg/ml, FDP 2.1 microg/ml and D-dimer 4.8 microg/ml. To obtain a 100% negative predictive value for the diagnosis of VTE, the SF was less than 5.2 microg/ml, FDP was less than 1.3 microg/ml, and D-dimer was less than 0.5 microg/ml. Our findings suggest that the SF assay is useful for the diagnosis and exclusion of VTE.

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Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation

Cited by 33 publications

References 29 publications

Usefulness of a latex agglutination assay for FDP D-dimer to demonstrate the presence of postmortem blood

Usefulness of a latex agglutination assay for FDP D-dimer to demonstrate the presence of postmortem blood

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

Elevated levels of soluble fibrin in patients with venous thromboembolism

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