Increased subclinical atherosclerosis in patients with chronic plaque psoriasis

Evensen, Kristin; Slevolden, Ellen; Skagen, Karolina; Rønning, Ole Morten; Brunborg, Cathrine; Krogstad, Anne‐Lene; Russell, David

doi:10.1016/j.atherosclerosis.2014.10.008

Cited by 27 publications

(28 citation statements)

References 36 publications

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“…Conversely, how skin-resident microbes influence immune responses systemically or at distant sites is an important area for further research. Processes that were previously thought to involve skin-limited inflammation, such as plaque psoriasis, have now been linked to an increase in systemic inflammatory co-morbidities, such as atheroscle-rotic cardiovascular disease 151–154 . Indeed, many types of immune cell are known to traffic in and out of skin during both homeostasis and inflammation 155–157 .…”

Section: Discussionmentioning

confidence: 99%

Skin microbiota–host interactions

Chen

Fischbach

Belkaid

2018

Nature

540

396

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The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi and viruses. These microbes—collectively referred to as the skin microbiota—are fundamental to skin physiology and immunity. Interactions between skin microbes and the host can fall anywhere along the continuum between mutualism and pathogenicity. In this Review, we highlight how host–microbe interactions depend heavily on context, including the state of immune activation, host genetic predisposition, barrier status, microbe localization, and microbe–microbe interactions. We focus on how context shapes the complex dialogue between skin microbes and the host, and the consequences of this dialogue for health and disease.

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Section: Discussionmentioning

confidence: 99%

Skin microbiota–host interactions

Chen

Fischbach

Belkaid

2018

Nature

540

396

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“…Subclinical atherosclerosis was found in 30% (19/62) patients with Hurley stage II and III disease. In comparison, a recent study of psoriasis patients found subclinical atherosclerosis in 20% . This association is lost if the younger patients are included in the analysis, possibly because atherosclerosis is strongly age dependant.…”

Section: Discussionmentioning

confidence: 78%

Assessment of subclinical atherosclerosis in hidradenitis suppurativa

Pascual

González

Corona

et al. 2017

Acad Dermatol Venereol

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“…Rheumatoid arthritis, psoriasis and other diseases associated with chronic systemic inflammation have been associated with increased risk of CVD [16–23]. Our study assessed whether three inflammatory dermatologic conditions: psoriasis, AD, and rosacea contribute to an independent risk of cardiovascular at 1 year following diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Marshall

Moustafa

Hawkins

et al. 2016

Dermatol Ther (Heidelb)

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IntroductionInflammation is an established component of cardiovascular disease (CVD) and an underlying factor of several dermatologic conditions including rosacea, atopic dermatitis, and psoriasis. Identifying potential associations between these dermatologic and cardiovascular diseases can better inform holistic healthcare approaches. The objective of this study was to determine whether rosacea, psoriasis or atopic dermatitis are independent risk factors for CVD 1 year following diagnosis.MethodsUsing a large commercial claims database of 21,801,147 lives, we employed a propensity-matched logistic regression to evaluate the association between diagnoses of rosacea, psoriasis, or atopic dermatitis and a 1-year risk of being diagnosed with cardiovascular disease. Control patients were matched based on health-care utilization, age and overall health status as defined by a modified Deyo–Charlson comorbidity index.ResultsThe analysis included 2105 rosacea, 622 atopic dermatitis, 1536 psoriasis, and 4263 control patients. Compared to propensity-matched controls, the adjusted odds of cardiovascular disease were not higher in patients with rosacea (odds ratio: 0.894, p = 0.2713), atopic dermatitis (OR 1.032, p = 0.8489), or psoriasis (OR 1.087, p = 0.4210). In univariate analysis, the unadjusted odds of cardiovascular disease was higher in patients with psoriasis (OR 1.223, p = 0.0347).ConclusionsLimitations of this study include the short follow-up period and inclusion of only commercially insured patients limit the generalizability of these findings. In this large study of patients with rosacea, atopic dermatitis, and psoriasis, we did not detect an increased 1-year risk of cardiovascular disease after adjusting for confounders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-016-0144-3) contains supplementary material, which is available to authorized users.

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Increased subclinical atherosclerosis in patients with chronic plaque psoriasis

Cited by 27 publications

References 36 publications

Skin microbiota–host interactions

Skin microbiota–host interactions

Assessment of subclinical atherosclerosis in hidradenitis suppurativa

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

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