Increased substitution rate in H5N1 avian influenza viruses during mass vaccination of poultry

Wang, ZhaoGuo; Jiang, Wenming; Liu, Shuo; Hou, Guangyu; Li, Jinping; Wang, Zhiyu; Chen, Ji Ming

doi:10.1007/s11434-012-5215-y

Cited by 13 publications

(14 citation statements)

References 48 publications

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“…Sustained circulation of H5N1 in terrestrial poultry and concurrent selection pressures, such as large-scale vaccination of poultry have led to the genetic and antigenic divergence of this lineage into several subgroups (clades 2.1.1, 2.1.2, and 2.1.3) (Cattoli et al, 2011; WHO OIE FAO H5N1 Evolution Working Group, 2012; Smith et al, 2006b; Wang et al, 2012). Java harbored ancestors to all three 2.1 sublineages in 2004, further indicating that the viral introduction had occurred here (WHO OIE FAO H5N1 Evolution Working Group, 2012; Lam et al, 2012; Smith et al, 2006b).…”

Section: Expansion Of Genotype Z In South East Asia (2003–2004)mentioning

confidence: 99%

Natural history of highly pathogenic avian influenza H5N1

2013

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The ecology of highly pathogenic avian influenza (HPAI) H5N1 has significantly changed from sporadic outbreaks in terrestrial poultry to persistent circulation in terrestrial and aquatic poultry and potentially in wild waterfowl. A novel genotype of HPAI H5N1 arose in 1996 in southern China and through ongoing mutation, reassortment, and natural selection, has diverged into distinct lineages and expanded into multiple reservoir hosts. The evolution of Goose/Guangdong-lineage highly pathogenic H5N1 viruses is ongoing: while stable interactions exist with some reservoir hosts, these viruses are continuing to evolve and adapt to others, and pose an un-calculable risk to sporadic hosts, including humans.

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Section: Expansion Of Genotype Z In South East Asia (2003–2004)mentioning

confidence: 99%

Natural history of highly pathogenic avian influenza H5N1

2013

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“…Fifth, some live attenuated coronaviruses can regain their virulence, 9 and this is not a concern of the LPV strategy. Sixth and importantly, other types of vaccines have the potential to accelerate mutation and diversification of the targeted virus to escape the induced immunity, 38 while mass inoculation of the single strain of the LPV, the immunity induced by the LPV, and the medications to inhibit the replication of the LPV, all have the potential to inhibit the replication of diversified SARS-CoV-2 circulating in different regions of the world.…”

Section: Accepted Articlementioning

confidence: 99%

Potential of live pathogen vaccines for defeating the COVID‐19 pandemic: History and mechanism

Chen

Chen²

2020

Journal of Medical Virology

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The whole world has entered a terrible crisis with a huge and increasing amount of human deaths and economic loss in fighting the pandemic of COVID-19 caused by the novel coronavirus termed SARS-CoV-2. The live pathogen vaccine (LPV) strategy, which originated in ancient China for fighting smallpox, has been applied successfully in the USA military recruits for decades to control acute respiratory diseases caused by types 4 and 7 adenoviruses. This strategy has also been widely employed in veterinary medicine. These facts suggest a fast way out of the current pandemic crisis, namely that SARS-CoV-2 could be directly used as a live vaccine. Beyond the two traditional mechanisms to guarantee the LPV's safety (SARS-CoV-2 is not highly pathogenic; the LPV is inoculated bypassing the respiratory sites of pathology), three novel mechanisms to further ensure the LPV's safety are available (the virus replication is inhibited with early use of an antiviral drug; symptomatic LPV recipients are cured with convalescent plasma; the LPV is inoculated in hot seasons). This LPV strategy has multiple potential advantages over other options, and could reduce This article is protected by copyright. All rights reserved. Accepted Articlegreatly the morbidity and mortality as well as economic loss caused by the pandemic. The safety and efficacy of this strategy should be investigated strictly using animal experiments and clinical trials, and even if the experiments and trials all support the strategy, it should be implemented with enough cautiousness. Highlights The world has entered a terrible crisis in fighting the COVID-19 pandemic  Live pathogen vaccines (LPV) defeated infectious disease caused by adenoviruses  The LPV strategy has been widely employed in veterinary medicine  The LPV strategy could be a way out of the COVID-19 pandemic crisis  Five mechanisms can be employed to ensure the safety of the LPV of SARS-CoV-2  The LPV strategy should be examined with animal experiments and clinical trials

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“…Despite the successes with vaccination strategies in reducing infection in poultry and human, some countries still face challenges to eliminate H5N1 virus in poultry (Domenech et al, 2009). One of the major problems is drift in antigenicity in viruses that develops due to vaccine pressure, particularly when vaccination is not implemented properly (Savill et al, 2006;Wang et al, 2012). Antigenic variants have been detected in China, Egypt and Indonesia following H5N1 vaccination (Domenech et al, 2009;Cattoli et al, 2011;Wang et al, 2012).…”

Section: Emergence Of Variants In Vaccinated Poultrymentioning

confidence: 99%

“…One of the major problems is drift in antigenicity in viruses that develops due to vaccine pressure, particularly when vaccination is not implemented properly (Savill et al, 2006;Wang et al, 2012). Antigenic variants have been detected in China, Egypt and Indonesia following H5N1 vaccination (Domenech et al, 2009;Cattoli et al, 2011;Wang et al, 2012). A complex genetic drift in HA has been reported in Egyptian H5N1 viruses under AI vaccine pressure where high mutations were observed at residues 43 and 71 (epitope E), 110 (epitope A), 129 (epitope A and receptor binding site), 140, 141 and 144 (epitope B), 151, 185, 192 and 226 (epitope D) and 154 (epitope D and glycosylation site) (Abdel-Moneim et al, 2011).…”

Section: Emergence Of Variants In Vaccinated Poultrymentioning

confidence: 99%

Evolution and Spread of Avian Influenza H5N1 Viruses

Tosh¹

2014

Adv. Anim. Vet. Sci.

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The Asian lineage of H5N1 avian influenza virus emerged from geese (A/Goose/Guangdong/1/96) in China in 1996, and is continuing its spread infecting domestic poultry, other birds and sporadic infection to humans revealing its pandemic potential. Since late 2003, H5N1 virus has been reported over 60 counties in Asia, Europe and Africa killing millions of poultry and infected humans in 16 countries with a total of 650 confirmed cases including 386 fatal have been reported to WHO. Spread of H5N1 virus has been linked with bird migration, although trade of poultry and poultry products has also been attributed in the spread. During the last one and half decades of circulation in poultry, the H5N1 virus has undergone significant genetic diversification leading to emergence of 10 major virus clades (clades 0-9), with subsequent diversification into 2nd-, 3rd-and 4th-order clades. Vaccination is one of the strategies for control and prevention of H5N1 virus infection; however, some countries still face challenges to eliminate H5N1 virus in poultry. One of the major problems is antigenic drift in viruses that develops due to vaccine pressure, particularly when vaccination is not implemented properly. Two classes of anti-viral drugs (neuraminidase inhibitors and adamantanes) are available for treatment and prophylaxis of influenza; however, there is emergence of drug resistant variants in poultry and humans. Widespread circulation and ever changing nature of H5N1 virus make avian influenza control program more difficult. Therefore, educational programs to enhance awareness on avian influenza, animal husbandry practices and biosecurity measures are important in control of the disease. All copyrights reserved to Nexus® academic publishers

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Increased substitution rate in H5N1 avian influenza viruses during mass vaccination of poultry

Cited by 13 publications

References 48 publications

Natural history of highly pathogenic avian influenza H5N1

Natural history of highly pathogenic avian influenza H5N1

Potential of live pathogen vaccines for defeating the COVID‐19 pandemic: History and mechanism

Evolution and Spread of Avian Influenza H5N1 Viruses

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