Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness

Singleton, Robert C.; Pharr, George M.; Nyman, Jeffry S.

doi:10.1016/j.bone.2021.115949

Cited by 19 publications

(8 citation statements)

References 49 publications

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“…The determination of micro- and nanomechanical properties has been largely studied in human Ct bone ( Ascenzi and Bonucci, 1968 ; Lefèvre et al, 2019 ; Bala et al, 2011 ; Currey, 2002 ), but only few data are available for Tb ( Boivin et al, 2008b ; Zysset, 2009 ; Zysset et al, 1999 ; Turner et al, 1999 ; Rho et al, 1997 ; Hoffler et al, 2000 ). Currently, and maybe because they are influenced by several variables, such as type of bone (weight or non-weight bearing bones), orientation ( Zysset et al, 1999 ; Wolfram et al, 2010 ) (transverse or longitudinal direction), chronological age ( Mirzaali et al, 2016 ; Singleton et al, 2021 ), age of bone tissue (Ost vs Int) ( Singleton et al, 2021 ), scale level (BSUs, lamellae ( Zysset, 2009 )), testing conditions (dry or wet ( Wolfram et al, 2010 )), no obvious distinction has been shown between the nanomechanical properties of Ct and Tb by nanoindentation. Several studies showed that elasticity was higher in Ct than Tb ( Zysset et al, 1999 ; Rho et al, 1997 ; Rho et al, 1999a ; Fan et al, 2006 ; Rho et al, 1999b ; Fan et al, 2007 ), while others showed the inverse or no difference ( Hengsberger et al, 2001 ; Roy et al, 1999 ).…”

Section: Introductionmentioning

confidence: 99%

Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Farlay¹,

Falgayrac²,

Ponçon³

et al. 2022

Bone Reports

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Section: Introductionmentioning

confidence: 99%

Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Farlay¹,

Falgayrac²,

Ponçon³

et al. 2022

Bone Reports

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“…In addition, there may be the significantly different responses to treatments in cortical and trabecular bone ( Feher et al, 2010 ; Burr, 2010 ; Yajima et al, 2007b ). Moreover, cortical bone is the most important element regarding bone strength ( Singleton et al, 2021 ; Ferretti et al, 1995 ). Fourth, we did not measure serum osteocalcin levels of the patients because it is unclear whether osteocalcin is important in mineralization in dialysis patients ( Ducy et al, 1996 ).…”

Section: Discussionmentioning

confidence: 99%

Micropetrosis in hemodialysis patients

et al. 2021

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Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads to increased bone fragility. However, micropetrosis of hemodialysis (HD) patients has not been discussed at all. Micropetrosis area per bone area (Mp.Ar/B·Ar) and osteocyte number per micropetrosis area (Ot.N/Mp.Ar) were measured in nine HD patients with renal hyperparathyroidism (Group I), twelve patients with hypoparathyroidism within 1 year after the treatment of renal hyperparathyroidism (Group II) and seven patients suffering from hypoparathyroidism for over two years (Group III). And bone mineral density (BMD) and tissue mineral density (TMD) were calculated using μCT to evaluate bone mineral content of iliac bone of the patients. These parameters were compared among the three groups. Only Mp.Ar/B·Ar was statistically greater in Group II and III compared to Group I in the parameters of bone mineral content and micropetrosis. However, the other parameters were not statistically different among the three groups. In long-term HD patients, BMD and TMD may be modified by the causes of renal insufficiency and the treatment of renal bone disease. We concluded that Mp.Ar/B·Ar was greater in patients with long-term hypoparathyroidism than both those with short-term hypoparathyroidism and with renal hyperparathyroidism. Special attention should be paid to avoid long-term hypoparathyroidism of the patients from the view point of increased fracture risk caused by increased micropetrosis area.

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“…In addition, improved detection of patients at risk of fractures may be also achieved by the incorporation of novel ultrasonic parameters. For example, cortical bone attenuation appears to be a factor of interest [60]. A recent study showed that this parameter could be experimentally estimated using Dictionary Learning and Orthogonal Matching Pursuit points of view [19].…”

Section: Plos Onementioning

confidence: 99%

Bi-Directional Axial Transmission measurements applied in a clinical environment

Minonzio

Ramiandrisoa²,

Schneider

et al. 2022

PLoS ONE

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Accurate measurement of cortical bone parameters may improve fracture risk assessment and help clinicians on the best treatment strategy. Patients at risk of fracture are currently detected using the current X-Ray gold standard DXA (Dual XRay Absorptiometry). Different alternatives, such as 3D X-Rays, Magnetic Resonance Imaging or Quantitative Ultrasound (QUS) devices, have been proposed, the latter having advantages of being portable and sensitive to mechanical and geometrical properties. The objective of this cross-sectional study was to evaluate the performance of a Bi-Directional Axial Transmission (BDAT) device used by trained operators in a clinical environment with older subjects. The device, positioned at one-third distal radius, provides two velocities: VFAS (first arriving signal) and VA0 (first anti-symmetrical guided mode). Moreover, two parameters are obtained from an inverse approach: Ct.Th (cortical thickness) and Ct.Po (cortical porosity), along with their ratio Ct.Po/Ct.Th. The areal bone mineral density (aBMD) was obtained using DXA at the femur and spine. One hundred and six patients (81 women, 25 men) from Marien Hospital and St. Anna Hospital (Herne, Germany) were included in this study. Age ranged from 41 to 95 years, while body mass index (BMI) ranged from 16 to 47 kg.m−2. Three groups were considered: 79 non-fractured patients (NF, 75±13years), 27 with non-traumatic fractures (F, 80±9years) including 14 patients with non-vertebral fractures (NVF, 84±7years). Weak to moderate significant Spearman correlations (R ranging from 0.23 to 0.53, p < 0.05) were found between ultrasound parameters and age, BMI. Using multivariate Partial Least Square discrimination analyses with Leave-One-Out Cross-Validation (PLS-LOOCV), we found the combination of VFAS and the ratio Ct.Po/Ct.Th to be predictive for all non traumatic fractures (F) with the odds ratio (OR) equals to 2.5 [1.6-3.4] and the area under the ROC curve (AUC) equal to 0.63 [0.62-0.65]. For the group NVF, combination of four parameters VA0. Ct.Th, Ct.Po and Ct.Po/Ct.Po, along with age provides a discrimination model with OR and AUC equals to 7.5 [6.0-9.1] and 0.75 [0.73-0.76]. When restricted to a smaller population (87 patients) common to both BDAT and DXA, BDAT ORs and AUCs are comparable or slightly higher to values obtained with DXA. The fracture risk assessment by BDAT method in older patients, in a clinical setting, suggests the benefit of the affordable and transportable device for the routine use.

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Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness

Cited by 19 publications

References 49 publications

Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Micropetrosis in hemodialysis patients

Bi-Directional Axial Transmission measurements applied in a clinical environment

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