Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (-)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines

Han, Jin-Yi; Kim, Chung-Soo; Lim, Kyuhee; Kim, Jong-Hoon; Kim, Seunghwan; Yun, Young Won; Hong, Jin Tae; Oh, Ki‐Wan

doi:10.1097/fjc.0b013e31822d93cb

Cited by 14 publications

(14 citation statements)

References 25 publications

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“…EGCG was shown to stimulate production of nitric oxide from endothelium in spontaneously hypertensive rats leading to vasodilation and decreased blood pressure. 74 Furthermore, EGCG was shown to counteract caffeine-induced increases in mean arterial pressure, adrenaline, and noradrenaline levels in the circulation of Wistar rats, 75 indicating its properties in preventing an increase in blood pressure. In addition, EGCG and green tea polyphenols are widely recognized as antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Chatree

Sitticharoon

Maikaew

et al. 2020

Exp Biol Med (Maywood)

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Obesity is one of major risk factors increasing chronic diseases including type II diabetes, cardiovascular diseases, and hypertension. The effects of epigallocatechin gallate (EGCG), the major active compound in green tea, on reduced obesity and improved metabolic profiles are still controversial. Furthermore, the effects of EGCG on human adipocyte lipolysis and browning of white adipocytes have not been elucidated. This study aimed to investigate the effects of EGCG on obesity, lipolysis, and browning of human white adipocytes. The results showed that, when compared to the baseline values, EGCG significantly decreased fasting plasma triglyceride levels ( P < 0.05), systolic blood pressure ( P < 0.05), diastolic blood pressure ( P < 0.05), and serum kisspeptin levels ( P < 0.05) after 8 weeks of supplement. On the other hand, supplement of EGCG in obese human subjects for 4 or 8 weeks did not decrease body weight, body mass index, waist and hip circumferences, nor total body fat mass or percentage when compared to their baseline values. The study in human adipocytes showed that EGCG did not increase the glycerol release when compared to vehicle, suggesting that it had no lipolytic effect. Furthermore, treatment of EGCG did not enhance uncoupling protein 1 ( UCP1) mRNA expression in human white adipocytes when compared with treatment of pioglitazone, the peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, suggesting that EGCG did not augment the browning effect of PPAR-γ on white adipocytes. This study revealed that EGCG reduced 2 metabolic risk factors which are triglyceride and blood pressure in the human experiment. We also showed a novel evidence that EGCG decreased kisspeptin levels. However, EGCG had no effects on obesity reduction in humans, lipolysis, nor browning of human white adipocytes. Impact statement Obesity has become the worldwide problem that causes adverse health consequences in individuals. The effects of EGCG on decreased obesity and improved metabolic profiles are still inconclusive. This study revealed that EGCG decreased 2 metabolic risk factors including blood pressure and triglyceride in human obese subjects but had no effect on obesity reduction. This study also showed a novel finding that EGCG decreased kisspeptin levels in human obese subjects. The study in human adipocytes showed that EGCG had no effects on lipolysis nor browning of human white adipocytes. These findings might suggest that EGCG treatment ameliorated metabolic parameters but did not reduce obesity in obese humans. However, further studies are required to explore the relationship between the effect of EGCG on reduction of blood pressure and kisspeptin levels.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Chatree

Sitticharoon

Maikaew

et al. 2020

Exp Biol Med (Maywood)

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“…In our study, blood pressure, serum glucose and lipids levels consistently increased significantly with increasing age. Some studies reported that EGCG may reduce blood pressure, lower serum glucose and lipids and improve insulin resistance in disease models (Potenza et al ., ; Han et al ., ); however, there are no such reports in healthy rats. In our study, we observed that EGCG had only a slight decreasing effect on the levels of blood pressure, serum glucose and lipids, which did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 94%

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats

et al. 2013

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SummaryIt is known that phytochemicals have many potential health benefits in humans. The aim of this study was to investigate the effects of long-term consumption of the phytochemical, epigallocatechin gallate (EGCG), on body growth, disease protection, and lifespan in healthy rats. 68 male weaning Wistar rats were randomly divided into the control and EGCG groups. Variables influencing lifespan such as blood pressure, serum glucose and lipids, inflammation, and oxidative stress were dynamically determined from weaning to death. The median lifespan of controls was 92.5 weeks. EGCG increased median lifespan to 105.0 weeks and delayed death by approximately 8-12 weeks. Blood pressure and serum glucose and lipids significantly increased with age in both groups compared with the levels at 0 week. However, there were no differences in these variables between the two groups during the whole lifespan. Inflammation and oxidative stress significantly increased with age in both groups compared with 0 week and were significantly lower in serum and liver and kidney tissues in the EGCG group. Damage to liver and kidney function was significantly alleviated in the EGCG group. In addition, EGCG decreased the mRNA and protein expressions of transcription factor NF-jB and increased the upstream protein expressions of silent mating type information regulation two homolog one (SIRT1) and forkhead box class O 3a (FOXO3a). In conclusion, EGCG extends lifespan in healthy rats by reducing liver and kidney damage and improving age-associated inflammation and oxidative stress through the inhibition of NF-jB signaling by activating the longevity factors FoxO3a and SIRT1.

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“…The authors also found that intraduodenal injections of decaffeinated OT lowered RSNA and blood pressure to the same degree as caffeinated OT, indicating that substances other than caffeine may function as effective modulators of RSNA and blood pressure. Han et al [66] provided additional evidence that EGCG counteracts caffeine-induced increases in arterial pressure, adrenaline and noradrenaline levels in the blood, and heart rate. The authors suggested that EGCG may exhibit these properties by decreasing the levels of catecholamines in the blood.…”

Section: Molecular Mechanisms Of Tea Regulating Blood Pressurementioning

confidence: 99%

Effects and Mechanisms of Tea Regulating Blood Pressure: Evidences and Promises

Wang

Huang

et al. 2019

Nutrients

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Cardiovascular diseases have overtaken cancers as the number one cause of death. Hypertension is the most dangerous factor linked to deaths caused by cardiovascular diseases. Many researchers have reported that tea has anti-hypertensive effects in animals and humans. The aim of this review is to update the information on the anti-hypertensive effects of tea in human interventions and animal studies, and to summarize the underlying mechanisms, based on ex-vivo tissue and cell culture data. During recent years, an increasing number of human population studies have confirmed the beneficial effects of tea on hypertension. However, the optimal dose has not yet been established owing to differences in the extent of hypertension, and complicated social and genetic backgrounds of populations. Therefore, further large-scale investigations with longer terms of observation and tighter controls are needed to define optimal doses in subjects with varying degrees of hypertensive risk factors, and to determine differences in beneficial effects amongst diverse populations. Moreover, data from laboratory studies have shown that tea and its secondary metabolites have important roles in relaxing smooth muscle contraction, enhancing endothelial nitric oxide synthase activity, reducing vascular inflammation, inhibiting rennin activity, and anti-vascular oxidative stress. However, the exact molecular mechanisms of these activities remain to be elucidated.

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Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (-)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines

Cited by 14 publications

References 25 publications

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats

Effects and Mechanisms of Tea Regulating Blood Pressure: Evidences and Promises

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