Increases in mature brain-derived neurotrophic factor protein in the frontal cortex and basal forebrain during chronic sleep restriction in rats: Possible role in initiating allostatic adaptation

Wallingford, J.K.; Deurveilher, Samüel; Currie, R. William; Fawcett, James P.; Semba, Kazue

doi:10.1016/j.neuroscience.2014.06.067

Cited by 25 publications

(17 citation statements)

References 55 publications

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“…Furthermore, BDNF mRNA levels in the cortex increase after sleep deprivation. 59 A relatively recent study by Martinowich et al 60 found that genetic manipulation that disrupts activitydependent BDNF expression results in behavioral impairments that are consistent with a deficit in sleep homeostasis. To buttress the important role BDNF plays in sleep regulation, Fujihara et al 61 showed that by subjecting rats to sleep deprivation there is a disturbance in BDNF levels for short periods.…”

Section: Neurochemical Correlatesmentioning

confidence: 99%

“…68 An elevated level of cytokines in the central nervous system could lead to the activation and further secretion of new cytokines and thus influence serotonergic, noradrenergic, and dopaminergic neurotransmission. 59 Even though our understanding of the mechanisms involved in sleep are still unknown, much has been achieved in terms of understanding how cytokine release regulates sleep. There is evidence to suggest that the proinflammatory cytokines, IL-1 and TNF-a, promote normal sleep physiology in the absence of an immune challenge, especially regarding NREMS, either by enhancing or inhibiting this form of sleep.…”

Section: Neurochemical Correlatesmentioning

confidence: 99%

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A Critical Review of Neurobiological Factors Involved in the Interactions Between Chronic Pain, Depression, and Sleep Disruption

Boakye

Olechowski

Rashiq

et al. 2016

The Clinical Journal of Pain

133

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Section: Neurochemical Correlatesmentioning

confidence: 99%

Section: Neurochemical Correlatesmentioning

confidence: 99%

A Critical Review of Neurobiological Factors Involved in the Interactions Between Chronic Pain, Depression, and Sleep Disruption

Boakye

Olechowski

Rashiq

et al. 2016

The Clinical Journal of Pain

133

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show abstract

“…The gene expression and protein levels of neurotrophic factors involved with cell growth and function (Boyd and Gordon 2003a, b) have also been shown to be affected by sleep deprivation (Cirelli and Tononi 2000a;Sei et al 2000;Fujihara et al 2003;Hamatake et al 2011;Ventskovska et al 2014;Wallingford et al 2014;Zielinski et al 2014). Most studies were concerned with BDNF, a neurotrophin of great importance for neuronal plasticity and survival (Ghosh et al 1994;Ventimiglia et al 1995;Lipsky and Marini 2007;Sossin and Barker 2007).…”

Section: Sleep Deprivation and Neurotrophic Factorsmentioning

confidence: 99%

Sleep Deprivation and Gene Expression

Souza

Ribeiro

2015

Current Topics in Behavioral Neurosciences

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Sleep occurs in a wide range of animal species as a vital process for the maintenance of homeostasis, metabolic restoration, physiological regulation, and adaptive cognitive functions in the central nervous system. Long-term perturbations induced by the lack of sleep are mostly mediated by changes at the level of transcription and translation. This chapter reviews studies in humans, rodents, and flies to address the various ways by which sleep deprivation affects gene expression in the nervous system, with a focus on genes related to neuronal plasticity, brain function, and cognition. However, the effects of sleep deprivation on gene expression and the functional consequences of sleep loss are clearly not restricted to the cognitive domain but may include increased inflammation, expression of stress-related genes, general impairment of protein translation, metabolic imbalance, and thermal deregulation.

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“…For instance, expression of BDNF is increased in the frontal cortex, basal forebrain and hippocampus following sleep loss in rats [26–28], which is associated with improved cognitive performance [26]. These findings suggest that BDNF may act to enhance cortical functioning in the areas where it is upregulated during sleep loss.…”

mentioning

confidence: 99%

Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele

Grant

Cain

Chang

et al. 2018

Behavioural Brain Research

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Accumulating evidence points to a genetic contribution to explain inter-individual vulnerability to sleep deprivation. A functional polymorphism in the BDNF gene, which causes a valine (Val) to methionine (Met) amino acid substitution at Codon 66, has been associated with cognitive impairment, particularly in populations with impaired frontal functioning. We hypothesised that sleep deprivation, which affects frontal function, may lead to cognitive dysfunction in Met allele carriers. To examine this, we investigated, in different BDNF genotypes, the effects of sleep deprivation on cognitive flexibility, as measured by response inhibition using the Stroop Color Naming Task. Thirty healthy, adults of European ancestry, including 12 heterozygous Met allele carriers and 18 Val/Val homozygotes, underwent 30-h of extended wakefulness under constant routine conditions. A computerised Stroop task was administered every 2 h. Error rate and reaction times increased with time awake for all individuals. Participants with the Val/Met genotype made more errors on incongruent trials after 20 h awake. While Val/Met participants also took significantly longer to respond when inhibiting a prepotent response irrespective of time awake, this was particularly evident during the biological night. Our study shows that carriers of the BDNF Met allele are more vulnerable to the impact of prolonged wakefulness and the biological night on a critical component of executive function, as measured by response inhibition on the Stroop task.

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Increases in mature brain-derived neurotrophic factor protein in the frontal cortex and basal forebrain during chronic sleep restriction in rats: Possible role in initiating allostatic adaptation

Cited by 25 publications

References 55 publications

A Critical Review of Neurobiological Factors Involved in the Interactions Between Chronic Pain, Depression, and Sleep Disruption

A Critical Review of Neurobiological Factors Involved in the Interactions Between Chronic Pain, Depression, and Sleep Disruption

Sleep Deprivation and Gene Expression

Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele

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