Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma

Hu, Jing Feng; Song, Xin; Zhong, Kuangbiao; Zhao, Xue; Zhou, Fu You; Xu, Rui; Li, Ji Lin; Wang, Xian Zeng; Li, Xue Min; Wang, Pan Pan; Lei, Ling; Wei, Meng Xia; Wang, Ran; Fan, Zong Min; Han, Xue; Chen, Yao; Li, Liu Yu; Ji, Jia Jia; Yang, Yuan; Li, Bei; Yang, Miao Miao; Yang, Hai; Chang, Fu Bao; Ren, Jing; Zhou, Sheng; Wang, Li Dong

doi:10.3389/fonc.2023.997776

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Recently, there has been an increasing trend to develop nomogram for cancer prognosis, primarily because of their userfriendly graphical interfaces enabling visualization of the prognostic strength of various relevant factors (29,30). Compared with the traditional TNM system, the advantage of nomogram is its ability to incorporate a wide array of prognostic indicators to formulate a noninvasive tool that could predict the prognosis according to an individual patient's profile (31,32).…”

Section: Discussionmentioning

confidence: 99%

Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma

Cheng

Fan

et al. 2023

Front. Oncol.

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BackgroundInflammation has been recognized to be a factor that substantially influences tumorigenesis and tumor prognosis. Hence, this study was aimed to investigate an inflammatory marker with the most potent prognostic ability and to evaluate the survival estimation capability of dynamic change in this marker for patients suffered from oral squamous cell carcinoma (OSCC).Methods469 patients’ inflammatory indicators including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic inflammatory response index (SIRI), were calculated. Their predictive abilities for overall survival (OS) were evaluated by Kaplan-Meier curves to screen for the one with the most potent prognostic value. The predictive ability of dynamic changes in this marker was verified and a predictive nomogram incorporating inflammatory indicators was developed.ResultsA high LMR was identified to be an indicator of a satisfactory survival rate. Compared with that of other inflammatory markers, area under the receiver operating characteristics (ROC) curve (AUC) of LMR for 1-year and 3-year OS was significantly larger (P<0.001). Dynamic LMR change remained an significant parameter for predicting OS (OR: 2.492, 95% CI: 1.246–4.981, p = 0.010). The nomogram incorporating LMR exhibited a superior prognostic significance than the TNM system, as suggested by the C-index (0.776 vs 0.651 in primary cohort; 0.800 vs 0.707 in validation cohort, P<0.001) and AUC.ConclusionsLMR was demonstrated to possess a more potent survival estimation capability than the other three inflammatory parameters. Dynamic changes in LMR serves as a significant parameter for overall survival estimation of primary OSCC patients. The established nomogram incorporating inflammatory markers showed more accuracy and sensitivity for survival estimation of primary OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma

Cheng

Fan

et al. 2023

Front. Oncol.

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“…Subsequently, utilizing our tissue microarray (TMA) cohort from Zhongshan Hospital, which encompassed 205 LUAD patients, we conducted immunohistochemistry staining for UPP1. The expression of UPP1 in tumor cells was then analyzed using the AI-based software, Aipathwell 25,26 . Our data indicated that elevated UPP1 expression was inversely correlated with both overall survival (OS) and recurrencefree survival (RFS) among LUAD patients (Fig.…”

Section: Tumor Cells and The Association Of Upp1 With Patient Prognosismentioning

confidence: 99%

“…Slides were scanned using Pannoramic MIDI (3DHISTECH, Hungary). For the quantification of IHC images, we used the AI-based IHC scoring software, Aipathwell, developed by Servicebio (Wuhan, China) 25,26 . This software generated four metrics: Positive Area (%), Mean Density, Area Density, and H-score (Supplementary Data 5).…”

Section: Immunohistochemistrymentioning

confidence: 99%

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Li,

Jiang,

Aye

et al. 2024

Nat Commun

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The complexity of the tumor microenvironment (TME) is a crucial factor in lung adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms of LUAD, we perform an integrative single-cell RNA sequencing (scRNA-seq) data analysis of 377,574 cells from 117 LUAD patient samples. By linking scRNA-seq data with bulk gene expression data, we identify a cluster of prognostic-related UPP1high tumor cells. These cells, primarily situated at the invasive front of tumors, display a stronger association with the immunosuppressive components in the TME. Our cytokine array analysis reveals that the upregulation of UPP1 in tumor cells leads to the increased release of various immunosuppressive cytokines, with TGF-β1 being particularly prominent. Furthermore, this UPP1 upregulation also elevates the expression of PD-L1 through the PI3K/AKT/mTOR pathway, which contributes to the suppression of CD8 + T cells. Cytometry by time-of-flight (CyTOF) analysis provides additional evidence of the role of UPP1 in shaping the immunosuppressive nature of the TME. Using patient-derived organoids (PDOs), we discover that UPP1high tumors exhibit relatively increased sensitivity to Bosutinib and Dasatinib. Collectively, our study highlights the immunosuppressive role of UPP1 in LUAD, and these findings may provide insights into the molecular features of LUAD and facilitate the development of personalized treatment strategies.

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NME4 suppresses NFκB2‐CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma

Zheng,

He,

Liang

et al. 2024

Immunology

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Thought of as a metastasis‐associated gene, however, NME/NM23 nucleoside diphosphate kinase 4 (NME4) has rarely been described in the context of the tumour microenvironment. To understand the immunological implications of NME4 in oesophageal squamous cell carcinoma (ESCC), we used multiplex immunohistochemistry to analyse the clinicopathological and prognostic importance of NME4 expression. Then, after establishing a syngeneic tumour model with a C57BL/6 mouse strain that can recapitulate the tumour microenvironment of humans, we examined the immunological involvement of NME4 expression. To explore the underlying molecular mechanism, via quantitative proteomics and protein microarray screening, we investigated the potential signalling pathways involved. The clinicopathological and prognostic importance of NME4 expression is limited in ESCC patients. In vivo, single‐cell RNA sequencing showed that NME4 strikingly prevented CD8+ T cells from infiltrating the tumour microenvironment in murine ESCC. Mechanistically, we mapped out the NFκB2‐CCL5 axis that was negatively controlled by NME4 in the murine ESCC cell line AKR. Collectively, these data demonstrated that regulation of NFκB2‐CCL5 axis by NME4 prevents CD8+ T cells infiltration in ESCC.

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Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma

Cited by 4 publications

References 41 publications

Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma

Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

NME4 suppresses NFκB2‐CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma

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