2020
DOI: 10.3390/nu12123690
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Increasing Expiratory Hydrogen in Lactose Intolerance Is Associated with Additional Food Intolerance/Malabsorption

Abstract: Single and/or combined food intolerance/malabsorption may cause nonspecific, functional gastrointestinal (GI) complaints. In lactose-intolerant patients we evaluated the influence of additional food intolerance/malabsorption with hydrogen (H2) breath tests. In a retrospective analysis of charts from 279 lactose-intolerant patients, we found 128 patients with only lactose intolerance (LIT). Then, we identified 106 LIT patients with additional histamine intolerance (HIT). Additionally, 45 LIT and HIT patients al… Show more

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Cited by 12 publications
(13 citation statements)
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“…Acquired DAO deficiency may be due to pharmacological effects or intestinal diseases, in particular lactase deficiency, celiac disease, and inflammatory diseases [ 24 ]. In intestinal diseases, the degree of DAO deficiency directly correlates with the severity of mucosal damage, intestinal permeability, and malabsorption of carbohydrates [ 24 , 74 , 75 , 76 ].…”
Section: Syndrome Of Histamine Intolerancementioning
confidence: 99%
“…Acquired DAO deficiency may be due to pharmacological effects or intestinal diseases, in particular lactase deficiency, celiac disease, and inflammatory diseases [ 24 ]. In intestinal diseases, the degree of DAO deficiency directly correlates with the severity of mucosal damage, intestinal permeability, and malabsorption of carbohydrates [ 24 , 74 , 75 , 76 ].…”
Section: Syndrome Of Histamine Intolerancementioning
confidence: 99%
“…During H 2 breath tests of patients with LIT, the presence of additional fructose malabsorption and HIT significantly increased expiratory H 2 values. This indicated that HIT embodies a separate GI disorder as food intolerance/malabsorption [ 64 ]. We described the fact that 55% of the patients with carbohydrate intolerance/malabsorption have serum DAO values below 10 U/mL as an indicator for HIT [ 5 ].…”
Section: Histamine Intolerance (Hit) Associated With Gastrointestinal (Gi) Disordersmentioning
confidence: 99%
“…Interestingly, the enzymatic activity of diamine oxidase and disaccharidases in small intestine biopsies of children strongly correlate with each other: DAO and lactase ( r = 0.80), DAO and maltase ( r = 0.70) as well as DAO and sucrase ( r = 0.55) [ 31 ]. Additionally, it was found that in adults increasing expiratory hydrogen in lactose intolerance is associated with additional histamine or fructose intolerance and that histamine intolerance frequently accompanies disaccharide malabsorption (HIT was present in 38% of lactose intolerant patients [ 32 ] and 36.9% of patients with carbohydrate malabsorption [ 30 ]). Nevertheless, evidence is limited and the questions stated above have to be answered in future thorough investigations of these interactions.…”
Section: Secondary Histamine Intolerance Aetiologymentioning
confidence: 99%
“…This is supported by studies correlating DAO/HNMT deficit (measured by SNPs) or increases in blood serum histamine concentrations with the severity of allergic diseases like atopic dermatitis, allergic rhinitis or asthma and bronchial hyperresponsiveness [ 15 , 16 , 18 , 19 ]. Additionally, DAO deficits were observed in bowel diseases, for example, celiac disease or acute gastroenteritis in children [ 21 , 22 ] and recurrent urticaria, colon adenoma, carbohydrate malabsorption as well as food allergies in adults [ 30 , 32 , 52 , 53 , 54 , 55 , 56 ]. Also, the DAO activity level was proposed as a bowel integrity marker [ 20 , 21 ].…”
Section: Comorbiditiesmentioning
confidence: 99%