Increasing Frequency and Transmission of HIV-1 Non-B Subtypes Among Men Who Have Sex With Men in the Swiss HIV Cohort Study

Ramirez, Jessy J Duran; Nguyen, Huyen; Kusejko, Katharina; Chaudron, Sandra E; Huber, Michael; Hirsch, Hans H.; Perreau, Matthieu; Ramette, Alban; Yerly, Sabine; Cavassini, Matthias; Stöckle, Marcel; Furrer, Hansjakob; Vernazza, Pietro; Bernasconi, Enos; Günthard, Huldrych F.; Kouyos, Roger D.

doi:10.1093/infdis/jiab360

Cited by 7 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the epidemic among MSM in Spain is becoming increasingly diverse through the expansion of multiple non-subtype B TCs, comprising or related to viruses circulating in other countries ( González-Domenech et al, 2018 ; Delgado et al, 2019 ). This phenomenon has been also documented in other European countries ( Dauwe et al, 2015 ; Ragonnet-Cronin et al, 2016b ; Verhofstede et al, 2018 ; Fabeni et al, 2019 ; Ramirez et al, 2021 ), where viruses introduced from abroad have expanded successfully among the MSM population.…”

Section: Discussionsupporting

confidence: 57%

“…In fact, almost all the largest TCs (≥30 patients) identified in our study were associated with MSM. HIV-1 molecular epidemiological studies in different countries, independently of the methodology used, have found a similar association ( Parczewski et al, 2017 ; Wertheim et al, 2017 ; Ramirez et al, 2021 ). Also, studies in other Spanish regions have found this association of TCs with MSM ( Pérez-Parra et al, 2015 ; González-Domenech et al, 2020 ).…”

Section: Discussionmentioning

confidence: 77%

See 1 more Smart Citation

Transmission Clusters, Predominantly Associated With Men Who Have Sex With Men, Play a Main Role in the Propagation of HIV-1 in Northern Spain (2013–2018)

et al. 2022

View full text Add to dashboard Cite

Viruses of HIV-1-infected individuals whose transmission is related group phylogenetically in transmission clusters (TCs). The study of the phylogenetic relations of these viruses and the factors associated with these individuals is essential to analyze the HIV-1 epidemic. In this study, we examine the role of TCs in the epidemiology of HIV-1 infection in Galicia and the Basque County, two regions of northern Spain. A total of 1,158 HIV-1-infected patients from both regions with new diagnoses (NDs) in 2013–2018 were included in the study. Partial HIV-1 pol sequences were analyzed phylogenetically by approximately maximum-likelihood with FastTree 2. In this analysis, 10,687 additional sequences from samples from HIV-1-infected individuals collected in Spain in 1999–2019 were also included to assign TC membership and to determine TCs’ sizes. TCs were defined as those which included viruses from ≥4 individuals, at least 50% of them Spaniards, and with ≥0.95 Shimodaira-Hasegawa-like node support in the phylogenetic tree. Factors associated to TCs were evaluated using odds ratios (OR) and their 95% CI. Fifty-one percent of NDs grouped in 162 TCs. Male patients (OR: 2.6; 95% CI: 1.5–4.7) and men having sex with men (MSM; OR: 2.1; 95% CI: 1.4–3.2) had higher odds of belonging to a TC compared to female and heterosexual patients, respectively. Individuals from Latin America (OR: 0.3; 95% CI: 0.2–0.4), North Africa (OR: 0.4; 95% CI: 0.2–1.0), and especially Sub-Saharan Africa (OR: 0.02; 95% CI: 0.003–0.2) were inversely associated to belonging to TCs compared to native Spaniards. Our results show that TCs are important components of the HIV-1 epidemics in the two Spanish regions studied, where transmission between MSM is predominant. The majority of migrants were infected with viruses not belonging to TCs that expand in Spain. Molecular epidemiology is essential to identify local peculiarities of HIV-1 propagation. The early detection of TCs and prevention of their expansion, implementing effective control measures, could reduce HIV-1 infections.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 77%

Transmission Clusters, Predominantly Associated With Men Who Have Sex With Men, Play a Main Role in the Propagation of HIV-1 in Northern Spain (2013–2018)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In fact, almost all the largest TCs (≥30 patients) identified in our study were associated with MSM. HIV-1 molecular epidemiological studies in different countries, independently of the methodology used, have found a similar association (Duran-Ramirez et al, 2021;Parczewski et al, 2017;Wertheim et al, 2017). Also, studies in other Spanish regions have found this association of TCs with MSM (González-Domenech et al, 2020;Pérez-Parra et al, 2015).…”

Section: Discussionmentioning

confidence: 64%

“…However, the epidemic among MSM in Spain is becoming increasingly diverse through the expansion of multiple non-subtype B TCs, comprising or related to viruses circulating in other countries (Delgado et al, 2019). This phenomenon has been also documented in other European countries (Dauwe et al, 2015;Duran Ramirez et al, 2021;Fabeni et al, 2019;Ragonnet-Cronin et al, 2016;Verhofstede et al, 2018), where viruses introduced from abroad have expanded successfully among the MSM population.…”

Section: Discussionmentioning

confidence: 93%

Transmission clusters, predominantly associated with men who have sex with men, play a main role in the propagation of HIV-1 in Northern Spain (2013-2018)

Gil

Delgado

Benito

et al. 2021

Preprint

View full text Add to dashboard Cite

Viruses of HIV-1-infected individuals whose transmission is related group phylogenetically in transmission clusters (TCs). The study of the phylogenetic relations of these viruses and the factors associated with these individuals is essential to analyze the HIV-1 epidemic. In this study, we examine the role of TCs in the epidemiology of HIV-1 infection in Galicia and the Basque County, two regions of Northern Spain. A total of 1158 newly HIV-1-diagnosed patients (NDs) from both regions diagnosed in 2013-2018 were included in the study. Partial HIV-1 pol sequences were analyzed phylogenetically by approximately-maximum-likelihood with FastTree 2. In this analysis, 10,687 additional sequences from samples from HIV-1-infected individuals collected in Spain in 1999-2019 were also included to assign and determine the TCs sizes. TCs were defined as those which included viruses from ≤4 individuals, at least 50% of them Spaniards, and with ≤0.95 Shimodaira-Hasegawa-like node support in the phylogenetic tree. Factors associated to TCs were evaluated using odds ratios (OR) and their 95% confidence intervals (CI). Fifty one percent of NDs grouped in 162 TCs. Male patients (OR: 2.6; 95% CI: 1.5-4.7) and men having sex with men (MSM) (OR: 2.1; 95% CI: 1.4-3.2) had higher odds of belonging to a TC compared to female and heterosexual patients, respectively. Individuals from Latin America (OR: 0.3; 95% CI: 0.2-0.4), North Africa (OR: 0.4; 95% CI: 0.2-1.0), and especially Sub-Saharan Africa (OR: 0.02; 95% CI: 0.003-0.2) were inversely associated to belonging to TCs compared to native Spaniards. Differences in distribution and sizes of local TCs were observed in both regions reflecting a different epidemic pattern. Our results show that TCs play an important role in the spread of HIV-1 infection in the two Spanish regions studied, where transmission between MSM is predominant. The majority of migrants were infected with viruses not belonging to TCs that expand in Spain. Molecular epidemiology is essential to identify local peculiarities of HIV-1 propagation. The early detection of TCs and prevention of their expansion, implementing effective control measures, could reduce HIV-1 infections.

show abstract

“…14,15 The densely sampled drug resistance sequence data base of the Swiss HIV Cohort Study (SHCS) was used in several previous projects to analyze key aspects of the HIV epidemics in Switzerland. 5,6,[16][17][18][19] So far, the drug resistance sequence data base of the Austrian HIV Cohort Study (AHIVCOS) in Austria was not used for a nation-wide phylogenetic analysis to study local transmission patterns, but subsets were used for collaborations. 20,21 Our main aim is to compare transmission dynamics of the local epidemics of Austria and Switzerland, including a quantification of infections occurring outside the country and between these 2 countries.…”

Section: Introductionmentioning

confidence: 99%

Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics

Kusejko

Tschumi

Chaudron

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

a,b the Swiss HIV Cohort Study and the Austrian HIV Cohort StudyObjectives: Phylogenetic analyses of 2 or more countries allow to detect differences in transmission dynamics of local HIV-1 epidemics beyond differences in demographic characteristics.Methods: A maximum-likelihood phylogenetic tree was built using pol-sequences of the Swiss HIV Cohort Study (SHCS) and the Austrian HIV Cohort Study (AHIVCOS), with international background sequences. Three types of phylogenetic cherries (clusters of size 2) were analyzed further: (1) domestic cherries; (2) international cherries; and (3) SHCS/AHIVCOS-cherries. Transmission group and ethnicities observed within the cherries were compared with the respective distribution expected from a random distribution of patients on the phylogeny. Results:The demographic characteristics of the AHIVCOS (included patients: 39141) and the SHCS (included patients: 129902) are very similar. In the AHIVCOS, 36.5% of the patients were in domestic cherries, 8.3% in international cherries, and 7.0% in SHCS/AHIVCOS cherries. Similarly, in the SHCS, 43.0% of the patients were in domestic cherries, 8.2% in international cherries, and 1.7% in SHCS/AHIVCOS cherries. Although international cherries in the SHCS were dominated by heterosexuals with men who have sex with men being underrepresented, the opposite was the case for the AHIVCOS. In both cohorts, cherries with one patient belonging to the transmission group intravenous drug user and the other one non-intravenous drug user were underrepresented. Conclusions:In both cohorts, international HIV transmission plays a major role in the local epidemics, mostly driven by men who have sex with men in the AHIVOS, and by heterosexuals in the SHCS, highlighting the importance of international collaborations to understand global HIV transmission links on the way to eliminate HIV.

show abstract

Increasing Frequency and Transmission of HIV-1 Non-B Subtypes Among Men Who Have Sex With Men in the Swiss HIV Cohort Study

Cited by 7 publications

References 40 publications

Transmission Clusters, Predominantly Associated With Men Who Have Sex With Men, Play a Main Role in the Propagation of HIV-1 in Northern Spain (2013–2018)

Transmission Clusters, Predominantly Associated With Men Who Have Sex With Men, Play a Main Role in the Propagation of HIV-1 in Northern Spain (2013–2018)

Transmission clusters, predominantly associated with men who have sex with men, play a main role in the propagation of HIV-1 in Northern Spain (2013-2018)

Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics

Contact Info

Product

Resources

About