Increasing Prevalence of Allergic Rhinitis in China

Zhang, Yuan; Zhang, Luo

doi:10.4168/aair.2019.11.2.156

Cited by 182 publications

(134 citation statements)

References 64 publications

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“…Constrained by the lack of objective tests in the relative studies, the prevalence of chronic rhinitis, especially prevalence of NAR, is still unclear. Without doubt, the global prevalence of AR is markedly increasing over the recent years 11,12 . It is estimated that AR and NAR affect 20%-30% and 17%-52% of the population 10,[13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Huang

Zhang

2020

Preprint

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Background It is difficult to discriminate allergic rhinitis (AR) and nonallergic rhinitis (NAR) in clinical practice due to the similar clinical manifestations. The study was to assess both the demographical and clinical features of AR and NAR in the real-world data of outpatients in China Methods It was a cross-sectional real-world study. AR and NAR were defined based on both subjective symptoms and objective specific serum IgE test. General demographic characteristics as well as clinical information was documented. Patients were further classified according the seasons of initial visiting hospital (during pollen seasons or not). A scoring system presented as nomograms for presence of AR was performed. Results In pollen season group, age distribution, the duration of rhinitis, comorbidity of asthma, food allergies and score of coughing were found significantly associated with AR. Besides, in non pollen season group, we found that ethnicity, age distributions, duration of rhinitis, comorbidity of asthma, food allergies, family history of allergy, together with scores of gritty eyes were associated factors of AR. Based on multivariate logistic model, we built two nomograms which included previously identified significant risk factors that could be easily acquired during clinical practice with predictive variables to assess their roles in predicting the risk of AR among outpatients with rhinitis. Conclusions The characteristics of patients with different phenotypes of chronic rhinitis are distinctive in different seasons and the developed monogram in this study might be beneficial for clinical practice.

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Section: Discussionmentioning

confidence: 99%

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Huang

Zhang

2020

Preprint

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“…Плохо контролируемый АР с выраженными симптомами представляет собой тяжелую хроническую болезнь верхних отделов дыхательных путей (severe chronic upper airway disease -SCUAD). АР обладает высокой коморбидностью и оказывает серьезное негативное влияние на качество жизни и социальную активность [1][2][3][4].…”

Section: практикаunclassified

Allergic rhinitis. Modern opportunities of pathogenetic therapy

2019

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Allergic rhinitis is a global public health problem at the present stage, given the high prevalence, the formation of therapy-resistant phenotypes, high comorbidity and the negative impact on all aspects of a patient’s life. Histamine is one of the main mediators of allergy, and therefore drugs number one in the treatment of patients with AR of all options are antihistamine drugs or H1-blockers. The innovative antihistamine drug of the second generation levocetirizine (Allerway®) prevents the development and facilitates the course of allergic reactions, also has anti-inflammatory and antiallergic action. Allerway® is bioequivalent to the original drug, has broad indications for use, has established itself as an effective drug with a good safety profile.

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“…Epidemiological studies have shown that AR affects at least half a billion people worldwide, and more than half of them suffer from moderate to severe AR [3]. In China, the prevalence of AR even rises to 34.3% of the general population, and rates still continue to increase [4][5]. Although without life threatening, AR exhibits negative in uence on people's quality of life and their work production, and brings about a high medical cost on both the individual and society.…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Signatures Associated with Disease Severity in Allergic Rhinitis

Xie

Zhang

Xie

et al. 2020

Preprint

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Abstract Background: Allergic rhinitis (AR) is a global healthcare problem with obscure pathogenesis, and few studies have evaluated the association between AR and metabolomics. The aim of this study was to identify differences in serum metabolomics profiling of AR patients compared to healthy controls and to explore novel biomarkers reflecting disease severity.Methods: Serum samples were collected form 29 healthy controls and 72 AR patients, including 30 mild AR patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomic profiling was performed by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) in serum samples. Orthogonal partial least square-discriminate analysis (OPLS-DA) was applied to assess the differences between AR patients and controls and for subgroups based on disease severity. Results: These analysis results successfully revealed distinct metabolite signatures which distinguished MAR patients and MSAR patients from health controls. In addition, MSAR patients also could be discriminated from MAR patients basing on their metabolic fingerprints. Most observed metabolite changes were related to pathways associated with glycine, serine and threonine metabolism, pyrimidine metabolism, sphingolipid metabolism, arginine and proline metabolism and fatty acid metabolism. Among these metabolites from dysregulated metabolic pathways, levels of sarcosine, sphingosine-1-phosphate (S1P), cytidine and linoleic acid significantly correlated with AR total nasal symptom score (TNSS) and visual analogue scale (VAS).Conclusions: MSAR patients have a distinctive serum metabolomics profile compared to MAR and health controls. These results suggest that metabolomic profiling may provide novel insights into pathophysiological mechanisms of AR and contribute to its evaluation of disease severity.

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Increasing Prevalence of Allergic Rhinitis in China

Cited by 182 publications

References 64 publications

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Allergic rhinitis. Modern opportunities of pathogenetic therapy

Serum Metabolomic Signatures Associated with Disease Severity in Allergic Rhinitis

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