Increasing Prevalence of Primary Biliary Cholangitis and Reduced Mortality With Treatment

Lü, Mei; Zhou, Yueren; Haller, Irina V.; Romanelli, Robert J.; VanWormer, Jeffrey J.; Rodriguez, Carla V.; Anderson, Heather; Boscarino, Joseph A.; Schmidt, Mark; Daida, Yihe G.; Sahota, Amandeep; Vincent, Jennifer; Bowlus, Christopher L.; Lindor, Keith D.; Zhang, Talan; Trudeau, Sheri; Li, Jia; Rupp, Loralee B; Gordon, Stuart C.

doi:10.1016/j.cgh.2017.12.033

Cited by 89 publications

(86 citation statements)

References 18 publications

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“…In South Korea, while the incidence of AIH was stable, the prevalence increased gradually from 2009 to 2013 . Rising prevalence of PBC over time has consistently been reported from the Netherlands, northern Italy and Denmark, Hong Kong, Canada, and the USA, and it is a point of debate whether the incidence of PBC is also increasing. In PSC, two systematic reviews concluded that the prevalence as well as the incidence of PSC seem to be increasing .…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] Estimation of prevalence of AILDs is critical to assess the burden of these diseases on public health. A number of epidemiological studies have been undertaken for AIH, [9][10][11][12][13][14][15][16][17][18][19] PBC, 13,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] and PSC [37][38][39][40][41][42][43] worldwide, and have shown that prevalence significantly varies depending on regions and ethnicities. Interestingly, several recent studies have indicated that prevalence of all three AILDs has been increasing over the years.…”

Section: Introductionmentioning

confidence: 99%

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Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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Aim Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate their prevalence. We carried out a nationwide, hospital‐based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys. Method We randomly selected health‐care facilities used in the survey from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with AILD who visited the facility in 2016. An identical survey was undertaken for AIH/PBC in 2004 and for PSC in 2007; we carried out a comparative analysis of these data. Results We selected 1793 departments from health centers all over Japan. Of them, 1078 (60.1%) responded to the questionnaires. The number of reported patients with AIH, PBC, and PSC was 8505, 10 847, and 906, respectively, and point prevalence was 23.9 (95% confidence interval, 23.3–24.5) for AIH (8.7 in 2004), 33.8 (33.0–34.6) for PBC (11.6 in 2004), and 1.80 (1.75–1.85) for PSC (0.95 in 2007) per 100 000 population. Male‐to‐female patient ratio of AILD was 1:4.3 for AIH (1:6.9 in 2004), 1:3.9 for PBC (1:7.1 in 2004), and 1:0.88 for PSC (1:1.4 in 2007). Conclusion The current study indicates an increasing trend of prevalence as well as male‐to‐female patient ratio of AILD in Japan.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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“…12,13 Multiple studies, including data from a 2012 systematic review and a multicenter PBC consortium within the United States, demonstrate the rising prevalence of the disease. [14][15][16] Hence, ensuring timely diagnosis and appropriate treatment strategies are imperative as the prevalence of PBC increases.…”

Section: Epidemiology Of Diseasementioning

confidence: 99%

<p>Osteoporosis in Primary Biliary Cholangitis: Prevalence, Impact and Management Challenges</p>

Trivedi¹,

Danford²,

Goyes³

et al. 2020

CEG

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Primary biliary cholangitis (PBC) is a chronic, cholestatic condition associated with symptoms that directly impact the quality of life in those afflicted with the disease. In addition to pruritus and fatigue, patients with PBC may develop metabolic bone disease from reduced bone density, such as osteopenia and osteoporosis. Osteoporosis increases the risk of fractures, as well as morbidity and mortality. The prevalence of osteoporosis in PBC is expected to increase in conjunction with the rising prevalence of PBC as a whole. Timely diagnosis, prevention and management of osteoporosis are crucial in order to optimize the quality of life. There is a paucity of data evaluating the management of osteoporosis in PBC. The optimal timing for diagnosis and monitoring is not yet established and is guided by expert opinion. National guidelines recommend screening for osteoporosis at the time of diagnosis of PBC. Monitoring strategies are based on results of initial screening and individual risk factors for bone disease. Identifying reduced bone density is imperative to institute timely preventive and treatment strategies. However, treatment remains challenging as efficacious therapies are currently lacking. The data on treatment of osteoporosis in PBC are mostly extrapolated from postmenopausal osteoporosis literature. However, this data has not directly translated to useful treatment strategies for PBC-related osteoporosis, partly because of the different pathophysiological mechanisms of the two diseases. The lack of useful preventive measures and efficacious treatment strategies remains the largest pitfall that challenges the management of patients with PBC. In this review, we comprehensively outline the epidemiology, clinical implications and challenges, as well as management strategies of PBC-related osteoporosis.

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“…The condition predominantly affects women older than 40 years, with a female/male ratio of 9:1 . Although the incidence of PBC appears to be stable, the overall prevalence of the disease is increasing . An individual's genetic susceptibility, epigenetic factors, and certain environmental triggers seem to play important roles.…”

Section: Epidemiologymentioning

confidence: 99%

Primary Biliary Cholangitis: A Brief Overview

Louie

Grandhe

Matsukuma

et al. 2020

Clinical Liver Disease

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Increasing Prevalence of Primary Biliary Cholangitis and Reduced Mortality With Treatment

Cited by 89 publications

References 18 publications

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

<p>Osteoporosis in Primary Biliary Cholangitis: Prevalence, Impact and Management Challenges</p>

Primary Biliary Cholangitis: A Brief Overview

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