Increasing resistance to quinolones: A four-year prospective study of urinary tract infection pathogens

Abstract

Abstract:A four-year prospective study was carried out to determine the incidence and rate of development of resistance by common urinary tract infection (UTI) pathogens to quinolone antimicrobial agents. Results show that there is high intrinsic resistance to the quinolones among strains of Pseudomonas aeruginosa (43.4%), Escherichia coli (26.3%), and Proteus spp. (17.1%). Over four years, rising rates of resistance were observed in P. aeruginosa (14.6% increase), Staphylococcus aureus (9.8%), and E. coli (9.7%). The highest potency was exhibited by ciprofloxacin (91.2%), levofloxacin (89.2%), and moxifloxacin (85.1%), while there were high rates of resistance to nalidixic acid (51.7%) and pefloxacin (29.0%). Coliforms, particularly E. coli (45%), remain the most prevalent causative agents of UTI while females within the age range of 20-50 years were most vulnerable to UTI.

Correlation of Bacterial Urinary Tract Infection with Prostate Specific Antigen Level in Patients Serum

“…Fig. (1),there were direct correlations between elevated prostate specific antigen level and patients age of positive culture with high tPSA level (r= 0.56) .These results agree with results of Veselyet al (2003) who found a correlation between high prostate specific antigen level of PSA and patients age of UTI (r = 0.28) (13) .…”

“…Urinary tract infection (UTI) can be defined as the persistent presence within the urinary tract of actively multiplying microorganisms. The UTI implies both microbial colonization of the urine and invasion of the lower or upper urinary tract by microorganisms (1) .When the infection affects the lower urinary tract it is known as a simple cystitis(a bladder infection) and when it affects the upper urinary tract it is known as pyelonephritis ( a kidney infection) (2) .Urinary tract infections are one of the most common bacterial infection in humans both in community and hospital setting (3) . Rarely they may be due to viral or fungal infections (4) .E.…”

Infecção do trato urinário causada por Escherichia coli uropatogênica resistente a antibióticos: um importante problema de saúde pública

“…In São Paulo, Brazil, from 2000 to 2003, UPEC resistance to FQs (e.g., ciprofloxacin and norfloxacin) increased from 9% to 14%, and in patients aged over 60 years, resistance to ciprofloxacin reached 24.3% (Kiffer et al, 2007). Similar results were described by other studies carried out in other countries (Araújo et al, 2011;Omigie et al, 2009). There was a gradual increase to 41% and 54% of UPEC resistant to ciprofloxacin isolated from the urine of community and nosocomialacquired infection in a Mexican cancer hospital, respectively.…”

Gram-negative Organisms from Patients with Community-Acquired Urinary Tract Infections and Associated Risk Factors for Antimicrobial Resistance: A Single-Center Retrospective Observational Study in Japan

“…The most frequently isolated species from community-acquired UTI was E. coli, which comprised the majority of antibiotic resistant GNRs. There have been several studies regarding the increasing rate of resistant GNRs globally [9,10,[17][18][19]. The ESBL-producing rate among E. coli isolated from patients with UTI increased from 10.4% to 13.0% in Canada, and from 7.8% to 18.3% in the US between 2010 and 2014 [10].…”