2004
DOI: 10.1002/rcm.1447
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Increasing the efficiency of pharmacokinetic sample procurement, preparation and analysis by liquid chromatography/tandem mass spectrometry

Abstract: The movement towards a 96-well format has greatly increased productivity and throughput in bioanalytical laboratories. Improvements in automated sample preparation and analytical methods have further contributed to increased productivity. We have focused on sample collection and transfer to the bioanalyst and have found improvements to the current available methods. The problem of manual transfers and plasma clotting issues can be overcome with the use of microtainers. Specifically, for illustrative purposes, … Show more

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Cited by 5 publications
(2 citation statements)
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“…Automation of analytical investigations of drug solutions is improving the throughput in degradation analysis [2] and driving efficiencies in bioanalytical assays [3] as well. Developing automated approaches for measuring changes in solution particle concentrations is important because solution particle characteristics are often a key indicator of product quality and safety.…”
Section: Introductionmentioning
confidence: 99%
“…Automation of analytical investigations of drug solutions is improving the throughput in degradation analysis [2] and driving efficiencies in bioanalytical assays [3] as well. Developing automated approaches for measuring changes in solution particle concentrations is important because solution particle characteristics are often a key indicator of product quality and safety.…”
Section: Introductionmentioning
confidence: 99%
“…But mass spectrometric detection and particularly electrospray ionization (ESI) mass spectrometry is limited by a phenomenon referred to as matrix-associated ion suppression or ion enhancement. [22][23][24][25] While there are working theories describing the mechanism of ion suppression/enhancement, 26 , 27 this phenomenon is complex and must be evaluated for each analyte and matrix. Several approaches have been taken to minimize or eliminate matrix ion effects.…”
Section: Introductionmentioning
confidence: 99%